Alkylating Agents

Question 0

SE: marked vesicant actions (skin blistering)

Answer 0

Mechlorthamine

Question 1

Forma DNA crosslinks, resulting in inhibition of DNA synthesis and function. Cell cycle non-specific

Treatment of Lymphomas

SE: hemorrhagic cystitis (due to acrolein)

Rescue agent: Mesna

Answer 1

Cyclophosphamide

Question 2

Forms DNA crosslinks. Resulting in inhibition of DNA synthesis and function. Cell cycle non specific

Treatment of colon cancer

SE:ototoxicitiy, nephrotoxicity,

Rescue agent: Amifostine

Answer 2

Cisplatin

Question 3

Forms hydrogen peroxide which generates free radicals that cause DNA strand scission.c ell cycle non specific

Hodgkin’s lymphoma, NHL, brain tumors

SE: disulfiram rxn, leukemogenesis

Answer 3

Procarbazine

Question 4

Testicular and ovarian tumors

SE: pulmonary fibrosis, bone marrow sparing

Answer 4

Bleomycin

Question 5

Treatment of brain tumors

Se: CNS toxicity

Answer 5

Carmustine