Antitumor Antibiotics Flashcards
0
Q
Treatment of testicular cancer
SE: pulmonary fibrosis, most specific for G2 phase of cell cycle
A
Bleomycin
1
Q
Intercalates between base pairs. Inhibits topoisomerase II. Generates free radicals. Cell cycle non specific
SE: dilated cardiomyopathy
Rescue agent: dexrazoxane
A
Doxorubicin
2
Q
Binds to double stranded DNA. Inhibits DNA dependant RNA synthesis. Cell cycle non specific.
Treatment of melanoma, wilm’s tumor and GTN
A
Actinomycin D
