Nancy Test 1 Vasculitis

Question 1

Who do you see giant cell arteritis in

Answer 1

elderly (>50)

Question 2

What does giant cell arteritis usually target

Answer 2

arteries in the head (temporal, opthalmic)

Question 3

What can giant cell arteritis cause

Answer 3

blindness

Question 4

What do you see histologically in Giant cell arteritis

Answer 4

nodular intimal thickening with granulomatous inflammation

Question 5

A patient comes in and has a headache and a tender artery to palpation on the head. What is this

Answer 5

Giant cell arteritis

Question 6

What must you do for giant cell arteritis biopsy. What can this tell you?

Answer 6

get a very long sample since it is segmental

A neg result doen NOT exclude diagnosis

Question 7

How do you treat giant cell arteritis

Answer 7

corticosteroids

Question 8

Who do you see takayasu in

Answer 8

ppl <50 (asian women)

Question 9

What does takayasu target normally

Answer 9

aortic arch

Question 10

What can you find in takayasu

Answer 10

pulseless disease in carotid, radial or ulnar (weakening of pulses with reduced blood pressure)

Question 11

What do 30% of people have in polyarterisis nodosa

Answer 11

chronic HepB with HbsAg-HbsAb

Question 12

ANCA in PAN

Answer 12

no

Question 13

where do you find PAN

Answer 13

KIDNEYS, spares lungs

Question 14

Which arteritis do you find aneurysmal nodules in

Answer 14

PAN

Question 15

What has transmural inflmmation with fibrinoid necrosis

Answer 15

PAN

Question 16

Who gets PAN more often?

Answer 16

young adults

Question 17

How do you treat PAN

Answer 17

corticosteroids and cyclophosphamides

Question 18

Who gets Kawasaki Syndrome

Answer 18

Infants <4yr old (asian)

Question 19

What artery does Kawasaki target

Answer 19

coronary

Question 20

What type of inflammation is kawasaki

Answer 20

transmural

Question 21

Symptoms of kawasaki

Answer 21

rash on palms and tongue. involvement of lips and lymph nodes

Question 22

Treatment of kawasaki

Answer 22

Aspirin and IV immunoglobulin

Question 23

What do we see in microscopic polyangiitis

Answer 23

MPO-ANCA (p-ANCA)

lesions are SAME age

Question 24

Is there granulomatous inflammation in microscopic polyangiitis? If no, what do you see?

Answer 24

No

focal transmural lesions

Question 25

What do you see fragmenting of neutrophils in

Answer 25

microscopic polyangiitis

Question 26

How do you treat microscopic polyangiitis

Answer 26

immunosuppression

Question 27

microscopic polyangiitis commonly presents with

Answer 27

hemoptysis, hematuria, proteinuria

Palpable purpura (if skin)

Question 28

Highlights of PAN

Answer 28

Necrotizing immune complex
Kidneys
Multiple progressive lesions

Question 29

Highlights of microscopic polyangiitis

Answer 29

MPO-ANCA
no lung involvement
Lesions same age

Question 30

Which type has eosinophilia and asthma

Answer 30

churg-strauss

Question 31

What do you see in churg strauss

Answer 31

MPO-ANCA

Question 32

triad for granulomatosis with polyangiitis

Answer 32

respiratory tract

focal necrotizing or granulomatous vasculitis

renal disease (glomerulonephritis)

Question 33

Marker for granulomatosis with polyangiitis

Answer 33

PR3-ANCA and immune complexes

Question 34

Who most commonly gets granulomatosis with polyangiitis

Answer 34

Males 40 yr old
persistent pneumonitis
chronic sinitis

Question 35

Treat granulomatosis with polyangiitis

Answer 35

immunosuppressives

cyclophosphamide

Question 36

What arteries does buerger target

Answer 36

tibial and radial

Question 37

Who commonly gets buerger

Answer 37

men who smoke heavily

Question 38

What has increased prevalence in buergers

Answer 38

HLA-A9 and HLA-B5

hypersensitivity to tobacco extracts

Question 39

What do you see microabscesses with central focus of neutrophils in

Answer 39

Buergers disease (thromboangiitis obliterans)

Question 40

What can buerger lead to

Answer 40

autoamputation with gangrene