Naloxone

Question 1

Brand Name

Naloxone

Answer 1

Narcan

Question 2

Drug Class

Naloxone

Answer 2

Opioid Antagonist

Antidote

Question 3

Indications

Naloxone

Answer 3

Opiate Overdose

Complete or Partial reversal of central nervous system

Respiratory depression induced by opioids

Decreased level of consciousness

Coma of unknown origin

Question 4

Mechanism of Action

Naloxone

Answer 4

Competitive inhibition at narcotic receptor sites

Reverse respiratory depression secondary to opiate drugs

Completely inhibits the effects of morphine

Question 5

Contraindications

Naloxone

Answer 5

Use with caution in narcotic-dependent patients

Use with caution in neonates of narcotic-addicted mothers

Question 6

Adverse Effects

Naloxone

Answer 6

Restlessness
Seizure
Dyspnea
Pulmonary Edema
Tachycardia
Hypertension
Dysrhythmias
Cardiac Arrest
N/V
Withdrawal Symptoms in opioid-addicted patient
Diaphoresis

Question 7

Precautions

Naloxone

Answer 7

Incompatible with alkaline solutions

Acute withdraw syndrome may result in combative patient

Question 8

Dose

Naloxone

Answer 8

Adult
0.4 - 2 mg (SIVP/IM/IO/SQ/ET/IN) *Repeat at 5 min intervals/max dose 10mg

Pedi
0.1 mg/kg (IV/IO/IM/SQ) *Repeat every 2 min as needed/max dose 2mg