NAFLD

Question 1

Description

Answer 1

Deposition of Fatty acids in the liver
From least severe form to most severe form:
-Steatosis
-Steatohepatitis (steatosis + inflammation)
-Fibrosis/cirrosis

Question 2

Development

Answer 2

Damage to insulin receptors

• Reduced fat released into the blood stream
• More FA taken up into the hepatocytes and converted into fat

Question 3

Associated with which diseases?

Answer 3

• Diabetes mellitus
• Hypertriglyceridemia
• Hyperlipidemia
• Obesity
• Hypertension

Question 4

Investigation

Answer 4

• AST/ALT>1
• albumin <34
• MR/CT/Ultrasound to look for fat deposition
• Liver biopsy

Question 5

Treatment

Answer 5

• weight/exercise management
• insulin sensatisers
• Vitamin E

Question 6

Symptoms

Answer 6

• Vague/None
• Jaundice
• Pain
• Hepatomegaly
• Ascites