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Physiology > NAFLD > Flashcards

NAFLD Flashcards

1
Q

NAFLD progression (4)

A

normal, NAFL, NASH, cirrhosis

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2
Q

NAFL

A

non alcoholic fatty liver

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3
Q

NASH

A

non alcoholic steatohepatitis

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4
Q

what is NAFL (2)

A

> 5% liver weight TG and simple steatosis

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5
Q

what is NASH (4)

A

steatosis, lobular inflammation, hepatocyte ballooning, with/without fibrosis

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6
Q

what is cirrhosis

A

fibrosis replaces healthy heaptocytes

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7
Q

NASH can also lead to

A

hepatocellular carcinoma

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8
Q

NAFLD is highest in

A

South America and Middle East

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9
Q

NAFLD lowest in

A

Africa

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10
Q

NAFLD in diabetes is highest in

A

Europe and Middle East

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11
Q

NAFLD in diabetes is lowest in

A

Africa

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12
Q

NAFLD higher in which patients

A

T2D (55.5%)

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13
Q

NAFLD is more common in people with

A

obesity (particularly men)

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14
Q

70-75% liver disease

A

NAFL

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15
Q

20-25% liver disease

A

NASH

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16
Q

5.8% liver disease

A

cirrhosis

17
Q

NAFLD risk factors (5)

A

metabolic syndrome, dyslipidaemia, obesity, hypertension

18
Q

How is NAFLD linked to MetSys

A

hepatic expression

19
Q

what genetic mutation can lead to increased fibrosis and lipid droplet accumulaion

A

PNPLA3 single nucleotide polymorphism

20
Q

what does PNPLA3 regulate (2)

A

lipolysis and lipid droplet size

21
Q

what gene variant protects from NASH

A

HSD17B13

22
Q

where is HSD localised

A

lipid droplets

23
Q

how is HSD17B13 mutated

A

truncated nonfunctional protein

24
Q

HSC

A

hepatic stellate cell

25
Q

consequences of NAFLD (3)

A

mortality, morbidity, costt

26
Q

how much per patient per annum

A

$10 000

27
Q

signalling from which cells leads to fibrinogensis (2)

A

stressed/injured hepatocytes and activated macrophages (kupffer cells)

28
Q
A

Physiology (9 decks)

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