NAFLD Flashcards
NAFLD progression (4)
normal, NAFL, NASH, cirrhosis
NAFL
non alcoholic fatty liver
NASH
non alcoholic steatohepatitis
what is NAFL (2)
> 5% liver weight TG and simple steatosis
what is NASH (4)
steatosis, lobular inflammation, hepatocyte ballooning, with/without fibrosis
what is cirrhosis
fibrosis replaces healthy heaptocytes
NASH can also lead to
hepatocellular carcinoma
NAFLD is highest in
South America and Middle East
NAFLD lowest in
Africa
NAFLD in diabetes is highest in
Europe and Middle East
NAFLD in diabetes is lowest in
Africa
NAFLD higher in which patients
T2D (55.5%)
NAFLD is more common in people with
obesity (particularly men)
70-75% liver disease
NAFL
20-25% liver disease
NASH
5.8% liver disease
cirrhosis
NAFLD risk factors (5)
metabolic syndrome, dyslipidaemia, obesity, hypertension
How is NAFLD linked to MetSys
hepatic expression
what genetic mutation can lead to increased fibrosis and lipid droplet accumulaion
PNPLA3 single nucleotide polymorphism
what does PNPLA3 regulate (2)
lipolysis and lipid droplet size
what gene variant protects from NASH
HSD17B13
where is HSD localised
lipid droplets
how is HSD17B13 mutated
truncated nonfunctional protein
HSC
hepatic stellate cell
