ICU acquired weakness

Question 1

how many in ICU pa in Australia

Answer 1

130 000

Question 2

how much does ICU cost per year

Answer 2

3 billion

Question 3

what % of ventilated ICU patients die before discharge

Answer 3

25%

Question 4

how many ICU patients die within 5 years of discharge

Answer 4

40%

Question 5

ICU AW

Answer 5

ICU acquired weakness

Question 6

what % of ICU AW

Answer 6

30-50%

Question 7

which disease has higher ICU AW

Answer 7

sepsis

Question 8

what is used to determine muscle thickness and mass loss

Answer 8

ultrasound

Question 9

after 10 days in ICU what % reduction in quads

Answer 9

20%

Question 10

risk factors of ICU AW (8)

Answer 10

hyperglycaemia, electrolyte imbalance, immobilisation, multiple organ failure, age, muscle relaxants, long term mechanical ventilation, glucocorticoids

Question 11

mean age for ICU AW

Answer 11

54.5

Question 12

ICU survival % with ICU AW

Answer 12

61%

Question 13

when is ICU AW excentuated

Answer 13

multiple organ failure

Question 14

what causes ICU AW

Answer 14

metabolic response to critical illness

Question 15

how does the metabolic response cause ICU AW (2)

Answer 15

catabolic activation and anabolic signal resistance

Question 16

what does ICU AW affect

Answer 16

multiple tissues

Question 17

how are multiple tissues impacted

Answer 17

cross talk

Question 18

critical cases that predispose (4)

Answer 18

trauma, sepsis, burns, surgery

Question 19

catabolic factors (3)

Answer 19

immobilisation, neuroendocrine adaptation, inflammation

Question 20

what can cytokines do

Answer 20

impair multiple cell functions

Question 21

what do cytokines cause (4)

Answer 21

increased protein breakdown, anabolic resistance, mitochondrial dysfunction, increased lipolysis

Question 22

what does mitochondrial dysfunction produce

Answer 22

excess ROS

Question 23

what does immobilisation do

Answer 23

inhibits protein synthesis

Question 24

what does neuroendocrine adaptation do

Answer 24

change hormone secretion

Question 25

how is protein breakdown increased (2)

Answer 25

activated ubiquitin proteasome pathway and activated autophagy

Question 26

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