Nacrotic analgesics Flashcards
what are Phenantherene Opium Alkaloids
morphine
codiene
what are Semisynthetic Morphine Derivatives
Di-acetyl morphine (heroin)
what are Synthetic Morphine Substitutes
fentayl
meperdine
what are Mixed Agonist-Antagonist Narcotic Analgesics
nubain (nalbuphine)
Talk about morphine absorption
1
Talk about morphine distribution
1
what is the drug that treat neontal asphyxia
naloxane
What does morphoine lead during pregency & labour
Preg : addicition
Labour : neontal asphyxia
Talk about codiene absorption
1
Oral biovilability of morphine & codiene
morphibe :25-30
codiene : 50
Talk about excretion & metabolism of morphine
1
Talk about duration of morphine & codiene
morphine :6-8 hrs
codiene : 2-4 hrs
what is percentage of opium at morphine & codiene
morphine :10
codiene : 1
what are opiate receptors and their causes
1
who lead to constipation at opoid receptorrs
muu & delta
What are affects of morphine on CNS
11
what are effects of morphine peripheary
1
Talk about tolerance of morphine
1
What does histamine release lead to
skin: itching & triple affect
R.C :bronchospasm
What does increase of A.D.H lead to
oligria
Talk about affects of codiene
potent : anti-tussive
weaker than morphine
what are therupatic uses of morphine
1
what are therupatic uses of codiene
1
what are drugs that are taken with codiene in visceral pain cases
asprin & paracetamol
what are adverse affects of morphine
10
what is the affect of large dose of morphine
decreasing vomiting center
what is the affect of small dose of morphine
increasing C.T.Z : vomiting & nausea
Talk about acute morphine poising
Manifestations
Death
Treatment
What is the affect of pure O2
apnea
what are the elements that used at stomach wash of mrophine
K-permengenate+charocal+MGSO4
what is specific morphinic antagonist
naloxane
Talk about chronic poisiong of morphine
Tolerance Due to Addict Sudden stop Managment
What is the drug that is gradual substitutent for morphine
methadone
Talk about contradictions of morphine
12:- Head injury Acute abdomen Intra cranial tension Pregnency & labour Liver disease Extreme age Myxdema Allergy History of addiction Alone with colic Respiratory diseaes Eplipsey
Talk about mepierdiene kinetics
50% orally bioavillability
Duration
Onset
Talk about mepiderne dynamics
4 less 4 no Local Large dose ADH Atropine like Drug interaction Antagonized by naloxane
Who is weaker than morphine by 1/5
codiene
Who is lesser than morphine by 1/10
mepridene
who is better than morphine at pre-anesthetic medication
mepridene
Talk about therupatic uses of mepridene
Obestric anesthesia
Alone in colic
Pre anesthetic medication
Severe visceral
example about CNS depressents
Benzodizpiens
Talk about naloxane
Block actions No effects on CNS depressents Pure antagonists selective on muu receptors 1 hour should be repeated Therupatic uses : 3
