Blood Flashcards

1
Q

Blood cogulation

A

parathrombin–>thrombin :3

thrombin : fibrinogen into fibrin

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2
Q

what is the element converting parathrombin

A

thrombiplastinase

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3
Q

Local heamostatic

A

Physcial
VC
Astringents : tannic acid & alum
local coagulants

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4
Q

what are local coagulants

A
thromboplastin : 2 
thrombin
fibrin glue
human fibrin foam
Absorbale gelatin sponge : 3-1
Oxycel : 2-2-2
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5
Q

what are systemic coagulants

A

fresh blood transfuion
Capillary fragility : 2
anti-coagulation therapy : 2

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6
Q

Talk about Vit K

A

Qunaine derviative
Vit K reductase–>dihydroquanine
hepatic synthesis

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7
Q

types of Vit K

A

Vit-k1: N-Fat-plant-bile
Vit-k2 :N-Fat-synthesied-Bile
Vit-k3: Synthestic-fat
Vit-k4: synthestic , water, x bile & displace

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8
Q

Talk about Anti coagulatnts

A

drugs remove ionic calcium

oral anti-coagulants

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9
Q

talk about drugs remove ionic calcium

A

by deioninzation
bound with Ca wihtout pp : chelation
vivo only
blood transfusion

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10
Q

talk about oral anti-coagulants

A

cumarines : W-D

indiandines : P-DP

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11
Q

Talk about heparin kinetcs

A
chemical name
strong or weak acid
administriation route : 3
distrbiruted : 1
Metabolism by what
excreted : 2 
onset
duration
milk
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12
Q

duration of heparin

A

4-6

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13
Q

drugs remove ionic calcium are what vitro or vivo

A

vitro

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14
Q

anti-coagulants are what vivo or vitro

A

effective vivo

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15
Q

dynamics of heparin

A

anti-coagulant : vivo & vitro / inactivation

lipemia clearing : lipoprotein lipsae enzyme

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16
Q

antagonists of heparin

A

promatine sulphate : neutrilization
excess promatine : bleeding
fresh blood transfusion

17
Q

what are adverse affects of heparin

A

hemorhage
hypersensitivty
prolonged use of full dose : Alo-osteoprosesis
thrombocytopenia: 2

18
Q

what is cause of mild & transient thrombocytopenia

A

heparin induced platlet aggregation

19
Q

what is cause of severe & presistent thrombocytopenia

A

heparin induced anti-platlet antibodies

20
Q

Talk about ancord kinetcs

A

enzyme of ancord snake venom
Thrombin like
fibrin : 3
uptake

21
Q

talk about ancord adverse affects

A

hemaorrhage & hpersensitivty

22
Q

talk about ancord anti-dote

A

fibrinogen & anti-venom

23
Q

talk about warafrin sodium kinetcs

A
type of derviative 
type of anticoagulant
adminstiration rout
distribution 
bounding to plasma albumnin
metabolization 
Onset
duration
24
Q

what is onset & duration of warafrin

A

1-2 days

5-7 days

25
Q

what are kinetcs of warafrin

A

dec. 2 enzymes
I isomer
Rodenticide.

26
Q

what are antagonists of warafrin

A

fresh blood transfusion

Polymendoine ( Vit-k1)

27
Q

what are side affects of warafrin

A
hypersensitivity
hemorrhage
GIT disturbances
tetangenacity
sudden stop : rebound thrombi embonic