Blood Flashcards
Blood cogulation
parathrombin–>thrombin :3
thrombin : fibrinogen into fibrin
what is the element converting parathrombin
thrombiplastinase
Local heamostatic
Physcial
VC
Astringents : tannic acid & alum
local coagulants
what are local coagulants
thromboplastin : 2 thrombin fibrin glue human fibrin foam Absorbale gelatin sponge : 3-1 Oxycel : 2-2-2
what are systemic coagulants
fresh blood transfuion
Capillary fragility : 2
anti-coagulation therapy : 2
Talk about Vit K
Qunaine derviative
Vit K reductase–>dihydroquanine
hepatic synthesis
types of Vit K
Vit-k1: N-Fat-plant-bile
Vit-k2 :N-Fat-synthesied-Bile
Vit-k3: Synthestic-fat
Vit-k4: synthestic , water, x bile & displace
Talk about Anti coagulatnts
drugs remove ionic calcium
oral anti-coagulants
talk about drugs remove ionic calcium
by deioninzation
bound with Ca wihtout pp : chelation
vivo only
blood transfusion
talk about oral anti-coagulants
cumarines : W-D
indiandines : P-DP
Talk about heparin kinetcs
chemical name strong or weak acid administriation route : 3 distrbiruted : 1 Metabolism by what excreted : 2 onset duration milk
duration of heparin
4-6
drugs remove ionic calcium are what vitro or vivo
vitro
anti-coagulants are what vivo or vitro
effective vivo
dynamics of heparin
anti-coagulant : vivo & vitro / inactivation
lipemia clearing : lipoprotein lipsae enzyme
antagonists of heparin
promatine sulphate : neutrilization
excess promatine : bleeding
fresh blood transfusion
what are adverse affects of heparin
hemorhage
hypersensitivty
prolonged use of full dose : Alo-osteoprosesis
thrombocytopenia: 2
what is cause of mild & transient thrombocytopenia
heparin induced platlet aggregation
what is cause of severe & presistent thrombocytopenia
heparin induced anti-platlet antibodies
Talk about ancord kinetcs
enzyme of ancord snake venom
Thrombin like
fibrin : 3
uptake
talk about ancord adverse affects
hemaorrhage & hpersensitivty
talk about ancord anti-dote
fibrinogen & anti-venom
talk about warafrin sodium kinetcs
type of derviative type of anticoagulant adminstiration rout distribution bounding to plasma albumnin metabolization Onset duration
what is onset & duration of warafrin
1-2 days
5-7 days
what are kinetcs of warafrin
dec. 2 enzymes
I isomer
Rodenticide.
what are antagonists of warafrin
fresh blood transfusion
Polymendoine ( Vit-k1)
what are side affects of warafrin
hypersensitivity hemorrhage GIT disturbances tetangenacity sudden stop : rebound thrombi embonic
