ANS parasympathetic Flashcards
talk about Choline esters
direct para
choline
quaternary
highly ionized : 3
talk about at.choline kinetics
Natural direct muscarnic : 2 blocked by atropine NN : 2 : ganglionic blocker NM : 2 : NM blocker : curare CNS : 2 choline QAC not absorbed orally
how at.choline metabolized
choline easterase enzyme
muscranic dynamics of at.choline
muscarnic EYE :2 GIT : 3 UB : 2 BRONCHI : 2 EXOCRINE GLANDS : 1 uterus : 1
nicotonic dynamics of at.choline
NM : 1
NN : 2
WHEN HYPO & HYPER TENSION OCCURS AT AT.CHOLINE
hypotension : muscranic
hypertension : nicotonic
Why at.choline not be used now
non selective
short duration
ineffective orally
talk about pilocarpine kinetcs
cholinomemtic alkaloids natural tertiary amine x metabolized excrted in urine absorbed orally passes BBB
TALK ABOUT DYNAMICS OF PILOCARPINE
mainly muscranic
few nicotonic
selective eye & exocrine glands
therupatic uses of pilocarpine
saliguage : 2
promote
micotic eye drops :5
kinetcs of atropine
well absorbed orally , mm, para passes BBB Distributed all over metabolized 70% by liver partial uncharged in urine 20% acidifcation : increase of excretion X
local actions of atropine
EYE : 2
skin & mm : 2*
systemic actions of atropine
Heart : 1 BV : 1 BP : 1 Respiratory : 2 GIT : 4 UB : 3 SKIN : 3 secretions : except 3 *
CNS actions of atropine
Mainly CNS… : 4
medulla : 2*
Basal ganglia : 2
therupatic uses of atropine
EYE : 2 skin : 1 Heart : 2 Respiratory: 1 GIT :3 UB : 2 Basal ganglia : 1 Medulla : 2 parasympathomemtic : 1 medication : 3
What are manifestaions of atropine
EYE : 4 SKIN : 1 HEART : 1 GIT+UB : 4 Allergy toxicity: 3
what is managment of atropine manifestations
psychosis : 1 respiratory : 1 Oral : 1 anhidrosis or hyperthermia : 1 phyostgamine : 2
what is drug that is used to correct central & periphery manifestaions
phyostgamine
what is blocker of parasympathomemtic of muscrainc
atropine
what is blocker of parasympathomemtic of NN
ganglion blocker
what is blocker of parasympathomemtic of NM
NM blcoker : curare
what is drug used for curare poinsing
neostgamine
what are contradictions of atropine
EYE : 1 Anhidrosis : 1 heart : 1 GIT+UB :3 allergy poinsing : 1
what is plant origin of pilocarpine
pilocarpus leaflet
what is other name of hyoscine
scoplamine
what does hyoscine contain
tertiary amine alkaloid
dynamics of hyoscine
similar to atropin but:- stronger : 2 weaker : 2 heart : 1 CNS : mainly 3 added with pain alone : 3 amnesia & euophria Medula : 2 Basal ganglia : 1 Large dose : 2
theruaptic uses of hysocine
better preanesthetic medication : 3
prophylaxis : 1
