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Pharmacollogy > ANS parasympathetic > Flashcards

ANS parasympathetic Flashcards

1
Q

talk about Choline esters

A

direct para
choline
quaternary
highly ionized : 3

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2
Q

talk about at.choline kinetics

A 
Natural direct 
muscarnic : 2 blocked by atropine
NN : 2 : ganglionic blocker
NM : 2 : NM blocker : curare
CNS : 2 
choline 
QAC
not absorbed orally
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3
Q

how at.choline metabolized

A

choline easterase enzyme

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4
Q

muscranic dynamics of at.choline

A 
muscarnic
EYE :2
GIT : 3
UB : 2
BRONCHI : 2
EXOCRINE GLANDS : 1
uterus : 1
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5
Q

nicotonic dynamics of at.choline

A

NM : 1

NN : 2

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6
Q

WHEN HYPO & HYPER TENSION OCCURS AT AT.CHOLINE

A

hypotension : muscranic

hypertension : nicotonic

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7
Q

Why at.choline not be used now

A

non selective
short duration
ineffective orally

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8
Q

talk about pilocarpine kinetcs

A 
cholinomemtic alkaloids
natural tertiary amine
x metabolized
excrted in urine
absorbed orally
passes BBB
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9
Q

TALK ABOUT DYNAMICS OF PILOCARPINE

A

mainly muscranic
few nicotonic
selective eye & exocrine glands

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10
Q

therupatic uses of pilocarpine

A

saliguage : 2
promote
micotic eye drops :5

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11
Q

kinetcs of atropine

A 
well absorbed orally , mm, para
passes BBB 
Distributed all over
metabolized 70% by liver
partial uncharged in urine 20%
acidifcation : increase of excretion X
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12
Q

local actions of atropine

A

EYE : 2

skin & mm : 2*

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13
Q

systemic actions of atropine

A 
Heart : 1
BV : 1
BP : 1
Respiratory : 2
GIT : 4
UB : 3
SKIN :  3
secretions : except 3 *
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14
Q

CNS actions of atropine

A

Mainly CNS… : 4
medulla : 2*
Basal ganglia : 2

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15
Q

therupatic uses of atropine

A 
EYE : 2
skin : 1
Heart : 2
Respiratory: 1
GIT :3
UB : 2
Basal ganglia : 1
Medulla : 2
parasympathomemtic : 1
medication : 3
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16
Q

What are manifestaions of atropine

A 
EYE : 4
SKIN : 1
HEART : 1
GIT+UB : 4
Allergy
toxicity:  3
17
Q

what is managment of atropine manifestations

A 
psychosis : 1
respiratory : 1
Oral : 1
anhidrosis or hyperthermia : 1
phyostgamine : 2
18
Q

what is drug that is used to correct central & periphery manifestaions

A

phyostgamine

19
Q

what is blocker of parasympathomemtic of muscrainc

A

atropine

20
Q

what is blocker of parasympathomemtic of NN

A

ganglion blocker

21
Q

what is blocker of parasympathomemtic of NM

A

NM blcoker : curare

22
Q

what is drug used for curare poinsing

A

neostgamine

23
Q

what are contradictions of atropine

A 
EYE : 1
Anhidrosis : 1
heart : 1
GIT+UB :3
allergy
poinsing : 1
24
Q

what is plant origin of pilocarpine

A

pilocarpus leaflet

25
Q

what is other name of hyoscine

A

scoplamine

26
Q

what does hyoscine contain

A

tertiary amine alkaloid

27
Q

dynamics of hyoscine

A 
similar to atropin but:-
stronger : 2
weaker : 2
heart : 1
CNS : mainly 3
added with pain alone : 3
amnesia & euophria
Medula : 2
Basal ganglia : 1
Large dose : 2
28
Q

theruaptic uses of hysocine

A

better preanesthetic medication : 3

prophylaxis : 1

Pharmacollogy (6 decks)

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