ANS Flashcards
Alpha 1 receptors actions
contraction :6
facilitate neuro m
increase total perip. R
Alpha 2 receptors actions
Dec. CNS
Dec symp.
Dec. renal
Presynatpic Beta actions
increase of noradernlaine
postsynaptic BETA 1 actions
Inc 4
Postsynaptic Beta 3 actions
increase lipolysis & thermogensis
postsyanptic beta 2 actions
Generlized VD Increase glucogenolysis increase insulin relase increase of reuptake of K Skeletal muscle twitches relaxation of uterus , GIT , UB Bronchodiltation
where is alpha 1 receptors
mainly postsynaptic
absorption of adernaline
not well by oral S.C inhalation glucoma caridac
Fate of adernaline
80 & metabilized
18& reuptake
2& uncharged
does adernaline pass BBB
no
Local actions of adernaline
Skin
MM
EYE *
Inhalataion
systemic actions of adernaline
CNS * EYE BV: 3 Heart: 3 BP Respiratory GIT * UB Uterus * SK muscle : 3 * Anti-allergic effect :2 endocrine * : 1 Metabolic : 4-3
Therupatic uses of adernaline
Bronchal asthma Acute hypoglycemia Glucoma Acute allergy * Cardiac arrest hemosatatic * with local anesthesia *
ADVERSE AFFECTS OF adernaline
twitches Heart problems EYE : 2 * CNS : 2 * VC :3 *
what is drug that used at heart problems treatment of adernaline
B1 blocker : atenlol
what is drug that used for VC treatment of adernline
Alpha blocker : parazosin
Contradictions of adernaline
Heart problems Thyrotoxicosis Around fingers & toes hypertension hemorrhage shock
what is cause of hemorrhage shock
renal V.C
Drugs interaction of adernaline
General anesthesia
Digitalis
Non-selective beta blockers :2
example for non-selective beta blockers
propanolol
what is source of adernaline
A cells of dura matter (80%) & some neurons at CNS
what happen if adernaline exposed to air or light or aqueous or alkaline medium
oxidized–>Adernochrome : very toxic & red
why at blood adernaline cant be oxidized
reducing agents : glutathione & aschrobic acid
what is source of nor-adernaline
postganglionic sympathateic
Adernal medulla (20%)
phenocytochroma (90%)
CNS
How can noradernaline be adminstrated
I.V injection
Dynamics of noradernaline
CNS EYE BV CVS : 2 * GIT,UB UTERUS* METABOLSIM:2*
Therupatic uses of noradernlaine*
Acute hypotension
Local anesthesia
Adverse affects of noradernaline
Gnagrene Arryhtemia & badycardia cerebral hemorhage abortion sudden stop-->sever hypotension
what are contradictions of noradernaline
hypertension hemorrhage shock coronary heart disease around finger or toe general anesthesia extra vasation sudden stop
what are kinetcs of dropamine
similar to noradernaline
what are dynamics of dopamine
small dose : Stimulate D : V.D
Moderate dose : stimulate D & B1 : VD+ inc. COP
large dose : VC
therupatic uses of dopamine
Resistant heart failure
Shock : 3
adverse affects of dopamine
vomiting & nausea
hypertension & HEART problems
talk about kinetcs of epipherine
Absorbed orally , mm, paraentral Pass BBB not metabolized by MAO excreted uncharged acidifcation
talk about dynamics of epipherine
Dual or mixed
idirect actions
similar to adernaline but weaker , slower,tachypylaxis
stimulate CNS
talk about amphetamine
more potent to CNS than ephedrine
addiction
what are actions of beta blockers
Heart * BV Anti-hypertensive* bronchi IOP metabolsim* ISA CNS Na channel block
what are uses of beta blockers
increase heart problems *2 Hypertension \+alpha blockers in phenocytocroma glucoma headche anxiety & panic syndrome tremors
difference between two types of angina
angina of work : can be used with b blocker
variant (prinzmetal) angina : X be used with b blocker
what is drug responsible for badchardia , heart failure
virpamil
what are contradictions of beta blockers
Variant angina + decrease heart prbolems P.V.D hypotension alone with phenocytochroma brocnho asthma paractolo WITH insulin hyperkalemia inc. TAG or dec, HDL sediation sudden stop
Talk about non selective beta blocker
Heart
Liver
Limbs *
Lung
Cardio selective beta 1 blocker
small dose with caution
example for Cardio selective beta 1 blocker
atenlol
bisprolol
metoprolol
example for alpha + beta blocker
carvilol + latenolol
What are central sympathoplegic drugs
alpha 2 agonists
imidozlone I1 agnoists
reserprin
example for alpha 2 agonists
alpha methyl dopa + colidene
example for imidozline I1 agonists
moxondine
who leads to more sedation
reserprin
2 enzymes of alpha methyl dopa
decarboxylase & beta hydroxylase
affects of alpha methyl dopa
Maintain RBF Inhibit catecholamines & serotonin Fluid , constipation , dry mouth CNS Allergy Hepatotoxcity hemaolytic anemia badicardia postural hypotension decrease renin
uses of alpha methyl dopa
hypertension : 3
can we use colidene at pregenency
no
what are disadvantages of colidene
large dose or iv : intial hypertension
sudden stop : sevre hypertension
what is treatment of sudden stop of colidene
alpha + beta blocker
