Na+ Channel Blockers--Nordgren Flashcards
1
Q
Why does ischemia in cardiac myocytes have the potential to cause arrhythmias?
A
damage to mitochondria
ATP problems
2
Q
Na+/K+ ATPase pump function
A
pump Na+ out of cell
3
Q
Na+/Ca2+ exchanger
A
uses Na+ gradient to move Ca2+ out of cells
4
Q
Why don’t we use digoxin for all patients with CHF?
A
digoxin may cause arrhythmias
5
Q
Loss of ATP leads to this ionic condition that affects arrhythmias
A
high [Na+]intracellular
high [K+]extracellular
more depolarzied resting membrane potential
more positive RMP–> longer recovery
6
Q
More positive RMP effect on myocyte recovery time
A
increased
fewer Na+ channels available
7
Q
A
