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4.1 > N5 - CNS Inf. III (Kuo) > Flashcards

N5 - CNS Inf. III (Kuo) Flashcards

1
Q

Early delay

  • Viral DNA polymerase
  • Thymidine kinase
A

Herpesvirus

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2
Q

Cell-cell bridges

A

Herpesvirus

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3
Q

Latent infection

A

Herpesvirus

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4
Q

Tzanck Smear

A

Multinucleated giant cells - Herpesvirus

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5
Q

Diagnosis for HSV encephalitis

A

PCR of CSF

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6
Q

HSV-1

A

Encephalitis (temporal lobe)

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7
Q

HSV-2

A

Meningitis

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8
Q

Stomatitis

A

HSV

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9
Q

Gingivostomatitis

A

Primary herpes

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10
Q

Site of viral latency

A

Trigeminal ganglia

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11
Q

Cold sore

Genitals

A

Recurrent herpes labialis

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12
Q

Trigeminal ganglia

A

HSV-1 latency

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13
Q

Lumbar & sacral ganglia

A

HSV-2 latency

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14
Q

HSV encephalitis severely affects

A

Temporal and inferior frontal lobes

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15
Q

reactivation from latency in the geniculate ganglioin

A

Bell’s Palsy

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16
Q
A
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17
Q

treatment of choice for HSV encephalitis, systemic disease, recurrent genital herpes

A

Acyclovir

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18
Q

used for treating HSV-1 resistant to acyclovir

A

Foscarnet

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19
Q

First step of Acyclovir MOA

A

herpesvirus-encoded thymidine kinase phosphorylates it

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20
Q

Respiratory spread

A

Varicella zoster virus

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21
Q

chickenpox

A

VZV

22
Q

Dewdrop on a rose petal

A

Varicella

23
Q

Interstitial pneumonia

A

Varicella - adults

24
Q

dorsal root or cranial nerve ganglia

thoracic dermatome

A

herpes zoster/shingles

25
Q

supporting cells of the CNS i.e. astrocytes

A

CMV

26
Q

oropharynx

A

CMV initiated infection

27
Q

Infant congenital infections

A

CMV

28
Q

Immunocompetent adults with CMV

A

Guillain-Barre

Acute brachial plexopathy

29
Q

Organ transplant recipients and AIDS patients with CMV

A

encephalitis

myelitis

retinits

polyradiculitis

30
Q

Neonate CMV transmission

A

Transplacental

Intrauterine

Cervical secretions

31
Q

Adult CMV transmission

A

Sexual - semen

Organ graft

Blood transfusion

32
Q

considered sexually transmitted disease

A

CMV

33
Q

heterophile-negative mononucleosis syndrome

A

CMV

34
Q

Tx of CMV

A

Ganciclovir

35
Q

Owl’s eye

basophilic intranuclear inclusion body

In uruine

A

CMV

36
Q

Arthropod-Borne Viruses (Arboviruses) familes

A

Flaviviridae (alphavirus)

Togaviridae (alphavirus)

Bunyaviridae

37
Q

yellow fever virus

A

Flaviviridae

38
Q

dengue virus

A

Flaviviridae

39
Q

Colorado tick fever virus

A

Reoviridae

40
Q

St. louis encephalitis

West nile

A

Flaviviridae

41
Q

North-central states

A

California virus - Bunyaviridae

42
Q

High mortality

A

Eastern equine encephalitis virus - Togaviridae

43
Q

Most common arbovirus

A

West nile

44
Q

Dead end host of arbovirus

A

Humans

Horses

45
Q

Reservoir of arboviruses

A

Marsh bird

46
Q

Vector of arbovirus

A

mosquito

47
Q

Arboviruses replicate within its

A

vector - insect

48
Q

diseases caused by alphaviruses & flaviviruses

A

Mild systemic disease

encephalitis

arthrogenic disease

hemorrhagic disease

49
Q

Arbovirus - systemic symptoms

A

Initial viremia

50
Q

Arbovirus- virus reproduction

A

secondary viremia

4.1 (14 decks)

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