N18 - Analgesics (Breivogel)

Question 1

paracrines

Answer 1

early immune response

Question 2

TNF, ILs

Answer 2

Chronic inflammation

Question 3

precursor for all eichosanoids

Answer 3

arachidonic acid

Question 4

precursor to all prostaglandins and thromboxanes

Answer 4

PGH₂

Question 5

Inhibits aggregation

Answer 5

OAH

Question 6

+ platelett aggregation

Answer 6

TXA₂

Question 7

Inhibits secretino of NSAIDs in to renal tubule

Answer 7

Probenecid

Question 8

Contraindications to NSAIDs

Answer 8

Hypersensitivity

Renal impairment

Pregnancy, acetaminophen

Question 9

aspirin

Answer 9

irreversibly inhibits COX-I

Reversibily inhibits COX-II

Question 10

Chemoprevention when used alone or with dipyridamole

Answer 10

Aspirin

Question 11

CNS effectiveness

Answer 11

acetaminophen

Question 12

Increases platelet aggregation

Answer 12

COX-I

Question 13

Involved in contractions

Answer 13

COX-II

Question 14

Inhibition of induced/CNS COX I & II

Answer 14

decreased pain, inflammation, fever

Question 15

Inhibition of COX II in uterus

Answer 15

decreased menstrual cramps

delayed labor

Question 16

Inhibition of COX I in platelets

Answer 16

chemoprevention

blood thinning/bleeding

Question 17

Inhibition of COX I in GI tract

Answer 17

ulcers

Question 18

Inhibition of COX II in vascular endothelium

Answer 18

heart attack

stroke

Question 19

Inhibition of COX I or II in fetus

Answer 19

closure of ductus arteriosus

Question 20

Inhibition of COX I & II in kidney

Answer 20

decreased RBF & GFR

other drug intoxication

Question 21

pt on meds for depression

Answer 21

methotrexate and Lithium elimination slowed

both have narrow therapeutic index

Question 22

Tx for NSAID overdose

Answer 22

gastric lavage

Question 23

Reye’s Syndrome

Answer 23

Due to virus in children <12 taking aspirin

Question 24

Suppository or enema alicylates for IBD

Answer 24

Sulfasalazine

Olsalazine

Mesalamine

Question 25

special use to close ductus arteriosus after birth stopping or slowing pre-term labor

Answer 25

Indomethacin

Question 26

Propionic acids

Answer 26

Ibuprofen + hydrocodone Naproxen Fluribiprofen Ketoprofen Fenoprofen Oxaprozin

Question 27

CNS side effects less common than with aspirin

Answer 27

Tolmetin Ketorolac Diclofenac

Question 28

Oral admin; SE - hemolytic anemia, visual distrubance

Answer 28

Mefenamic acid Meclofenamate

Question 29

Meloxicam Piroxicam Etodolac

Answer 29

- somewhat COX II selective

Question 31

Increased risk of cardiovascular events

Answer 31

Acetaminophen

Question 32

Decreased risk for gastric ulcer

Answer 32

acetaminophen