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4.1 > N18 - Analgesics (Breivogel) > Flashcards

N18 - Analgesics (Breivogel) Flashcards

1
Q

paracrines

A

early immune response

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2
Q

TNF, ILs

A

Chronic inflammation

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3
Q

precursor for all eichosanoids

A

arachidonic acid

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4
Q

precursor to all prostaglandins and thromboxanes

A

PGH2

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5
Q

Inhibits aggregation

A

OAH

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6
Q

+ platelett aggregation

A

TXA2

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7
Q

Inhibits secretino of NSAIDs in to renal tubule

A

Probenecid

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8
Q

Contraindications to NSAIDs

A

Hypersensitivity

Renal impairment

Pregnancy, acetaminophen

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9
Q

aspirin

A

irreversibly inhibits COX-I

Reversibily inhibits COX-II

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10
Q

Chemoprevention when used alone or with dipyridamole

A

Aspirin

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11
Q

CNS effectiveness

A

acetaminophen

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12
Q

Increases platelet aggregation

A

COX-I

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13
Q

Involved in contractions

A

COX-II

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14
Q

Inhibition of induced/CNS COX I & II

A

decreased pain, inflammation, fever

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15
Q

Inhibition of COX II in uterus

A

decreased menstrual cramps

delayed labor

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16
Q

Inhibition of COX I in platelets

A

chemoprevention

blood thinning/bleeding

17
Q

Inhibition of COX I in GI tract

A

ulcers

18
Q

Inhibition of COX II in vascular endothelium

A

heart attack

stroke

19
Q

Inhibition of COX I or II in fetus

A

closure of ductus arteriosus

20
Q

Inhibition of COX I & II in kidney

A

decreased RBF & GFR

other drug intoxication

21
Q

pt on meds for depression

A

methotrexate and Lithium elimination slowed

both have narrow therapeutic index

22
Q

Tx for NSAID overdose

A

gastric lavage

23
Q

Reye’s Syndrome

A

Due to virus in children <12 taking aspirin

24
Q

Suppository or enema alicylates for IBD

A

Sulfasalazine

Olsalazine

Mesalamine

25
Q

special use to close ductus arteriosus after birth

stopping or slowing pre-term labor

A

Indomethacin

26
Q

Propionic acids

A

Ibuprofen + hydrocodone

Naproxen

Fluribiprofen

Ketoprofen

Fenoprofen

Oxaprozin

27
Q

CNS side effects less common than with aspirin

A

Tolmetin

Ketorolac

Diclofenac

28
Q

Oral admin; SE - hemolytic anemia, visual distrubance

A

Mefenamic acid

Meclofenamate

29
Q

Meloxicam

Piroxicam

Etodolac

A
  • somewhat COX II selective
30
Q
A
31
Q

Increased risk of cardiovascular events

A

Acetaminophen

32
Q

Decreased risk for gastric ulcer

A

acetaminophen

33
Q
A

4.1 (14 decks)

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