N235 Flashcards
Thalamus and hypothalamus are part of what system
Limbic system
What does the forebrain consist of
Cerebellum and diencephalon (connects cerebellum to limbic)
A few major neurotransmitter categories
Chollinergics
Monoamines
Amino acids
Neuropeptides
Chollinergics
Acetylcholine
Primary in junctions of nerves and muscles
Plays a role in most all functions
Could play a role in Parkinson’s and Alzheimer’s
Monoamines
Norepinephrine
Dopamine
Serotonin
Histamine
Monoamine
Norepinephrine
Creates activity in the post synaptic terminal of nerves in ANS
Used for fight or flight
Regulates mood, cardiovascular system, sleep.
What mood disorders can be implicated from norepinephrine
Depression
Mania
Anxiety
Schizophrenia
Monoamine
Dopamine
Functions to regulate mood
Movement/ coordination
Increased dopamine levels are seen in what mood disorders
Mania
Schizophrenia
Monoamine
Serotonin
Play a role in sleep arousal, libido, mood, agitation.
Seen in schizophrenic disorders as well as anxiety states
Monoamine
Histamine
Functions as allergic and inflammatory reactions.
Sustaining wakefulness
Shown to be associated to some depressive illness
Amino acids types
Inhibitory and excitatory amino acids
Two of the biggest inhibitory amino acids
Gamma aminobutyic acid (GABA)
Glycine
How does GABA and glycine work
They prevent excitation of postsynaptic terminal impeding the impulse of electrical current. (Stops/slows down the message signal)
What disorder has GABA been implicated to
Anxiety disorders
Movement disorders
Some forms of epilepsy
What disorders has glycine been implicated with
Spastic disorders
What are the two common excitatory amino acids
Glutamate
Aspartate
Excitatory amino acids role
Relay sensory information
Regulate motor and spinal reflexes
Excitatory amino acids are implicated in
Neurodegenerative disorders
Huntingtons disease
Temporal epilepsy
The longer you are awake for what happens to your inhibitory amino acid numbers
They increase
Three main neuropeptides
Opioid peptides
Substance P
Somatostatin
Circadian rhythm
24 hour sleep wake cycle
Abnormal circadian rhythm correlated to
Depression
Bipolar disorder
Seasonal affective disorder
Neurochemicals that effect sleep
Serotonin
Norepinephrine
Acetylcholine
Melatonin
Is there a correlation of the immune system to psych illnesses
Yes
Serotonin can be triggered by micro biome in gut.
What is the function of the limbic system
Helps stabilize emotional behavior
What was the primary psychotropic drugs before 1950
Sedatives
Amphetamines
Post 1950 psychotropic therapy
Extended to anti anxiety
Antidepressant
Antipsychotic
Used in adjunct with psychotherapy
Role of nurses with psychotropic medications
Patient education
When to take
How to take them
Side effects
Benefit time line
How do psychotropic medications work
Psychotropic medications affect neurotransmitters
How does reuptake effect neurotransmitter
Inactivation
What are the 4 kinds of psychotropic medications
Antidepressant
Antipsychotic
Benzodiazepines
Psychostimulants
Anti anxiety agents would be used in
Anxiety disorders
Alcohol withdrawal
Convulsive disorder
Skeletal muscle spasm
Pre operative sedation
Anti anxiety agent action
Depression of the central nervous system
Antagonist of GABA receptors the inhibitory neurotransmitter
Anti anxiety medications
Benzodiazepines (pams)
Atypical anxiolytic
SSRI’s
SNRI’s
Off label prescriptions
Benzodiazepines
Anti anxiety
Lorazepam
Alprazolam
Clonazepam
Diazepam
Atypical anxiolytic
Anti anxiety
Busprione
SSRI’s
Anti anxiety
Selective serotonin reuptake inhibitors
Paroxetine
Fluoxetine
Citalopram
Sertraline
SNRI’s
Anti anxiety
Venlaxafine
Duloxetine
Desvenlafaxine
Off label prescriptions for anti anxiety
Propranolol
Prazosin
Gabapentin
Pregabalin
What medication is usually prescribed for a patient PRN with anxiety symptoms
Benzodiazepines
Pams usually used as a PRN anti anxiety
Alprazolam
What is the action of anti depressant medication
Increase the concentration of
Serotonin
Dopamine
Norepinephrine
Blocks the reuptake of these neurotransmitters
Classes of anti depressants
MAOI. (Monoamine oxidase inhibitors)
Tricyclic antidepressant (TCA)
Selective serotonin reuptake inhibitors (SSRI’s)
Serotonin/norepinephrine reuptake inhibitors (SNRI’s)
Norepinephrine/dopamine reuptake inhibitors (NDRI’s). Bupropion
Common SSRI’s
Paroxetine
Fluoxetine
Citalopram
How long does it take SSRI’s to take effect
No immediate affect maybe placebo
Improvement in 4-6 weeks
Full effect in months
Feel side effects before benefits
One problem with SSRI’s
Take a while before effect side effects are seen first.
Patients might have more energy
Might be prone to commit suicide
SSRI’s nurse education
Take at same time everyday
Night time to avoid side effects
Must be tapered off
Do not double dose if missed
Suicide assessment report any new thoughts immediately
SSRI’s side effects
Nausea
Agitation
Headache
Sexual dysfunction
Etc
Sleep disorders
Appetite disorders
Serotonin syndrome
Too much serotonin in the body causing over stimulation of receptors in CNS
Hyper reflex
Tachycardia
Tremor
Hypertension
Hyper bowel sounds
Dilated pupils
Sweating
Double dose
Taking 5HTP one cleave away from serotonin same effects
MAOI action
Inactivation of norepinephrine
Serotonin dopamine enzyme leaving more left
Drug interaction with other anti depressants
What do you have to do with MAOI’s
Avoid tyramine rich foods
Can cause hypertensive crisis
Cheeses
Red wine
Smoked meats
Soy sauce
MSG
Mood stabilizing agents
Lithium
Anti convulsant
Second generation atypical antipsychotic
What is the relation between lithium and sodium
Lithium is a salt that is a imperfect substitute for sodium
What happens if your sodium goes down to lithium
More sites are available for lithium risk for lithium toxicity
Lithium side effects
Weight gain
Lethargic
Hypotension
Hyponatremea
Narrow therapeutic range
High risk for patient discontinuation
Lithium therapeutic range
0.6-1.2mEq/L
1.0-1.5 mEq/L for mania
Don’t change diet enough sodium and water intake
Lithium toxicity
Nausea vomiting diarrhea
Over 2mEq/L tremors
Over 3.5mEq/L delirium seizures coma death
ADHD medication agents can they be dependent
Yes both physically and psychologically
When would you give ADHD medication
Early in the morning to avoid insomnia and sleep disorders