MYELODYSPLASTIC SYNDROME Flashcards
1
Q
CHARACTERISTICS OF MDS
A
- less than 20% blasts
- hypercellular and hyperactive bone marrow cells
- cytopenias
2
Q
Erythroid dysplasia
A
- nuclear changes e.g. budding
- RINGED SIDEROBLASTS
- immature cells have blue cytoplasm and nucleus
3
Q
What do ringed sideroblasts indicate?
A
SF3B1 mutation (RNA splicing)
4
Q
Myeloid dysplasia
A
- Pelger-huet cells
- Low granularity
- Vacuoles
5
Q
Megakaryocytic dysplasia
A
- Big MK fragments
- Smaller nucleus
6
Q
What chromosomal abnormality is associated with MDS?
A
5q deletion
This gives numerous small, hypolobated MKs
