CLL Flashcards
1
Q
Presentation
A
Disease of the elderly
PAINLESS LYMPHADENOPATHY
SMEAR CELLS
2
Q
Cytogenetics
A
FISH is done in interphase as it’s hard to get these cells into metaphase.
3
Q
CLL score
A
CD5 + CD23 + FMC7 - CD79 weak SmIg weak
Need 4 or 5 for Dx
4
Q
IgH mutations
A
50% unmutated and 50% mutated
Mutated gives better prognosis
5
Q
Immunophenotype
A
CD5+ CD19+ CD38+
CD10- CD20+ (rituximab)
6
Q
Chromosomal abnormalities in CLL
A
DELETIONS
- 13q del
- 11q del
- 17p del
7
Q
13q del
A
- Loss of mRNA
- MYB not regulated - cell proliferation
- Loss of RB gene - cell proliferation
- Good prognosis
8
Q
11q del
A
Intermediate prognosis
9
Q
17p del
A
TP53 deletion
Poor prognosis
10
Q
Morphology
A
- SMUDGE CELLS
- lymphocytosis
- cobblestone appearance to chromatin
- hight n-c ratio
