Multiple Myeloma Flashcards
1
Q
Morphology
A
- Large cells
- Eccentric nucleus
- Perinuclear halo
- clumped chromatin
2
Q
Immunophenotype in MM
A
- CD38+, CD138+
IMPORTANT: CD19-, CD20-, sIgM-
3
Q
Translocations in MM
A
t(4;14) gives FGF3 MMSET
t(11;14) gives CYCLIN D1 (same in MANTLE CELL LYMPHOMA)
t(6;14) gives CYCLIN D3
t(14;16) gives MAF
4
Q
FGF3 MMSET
A
t(4;14)
FGF3 causes unregulated cell proliferation
MMSET activates BCL2 for anti-apoptotic effect; MYC for proliferation
5
Q
CYCLIN D
A
t(11;14) and t(6;14)
RB is overstimulated (via phophorylation by cyclin Ds) so cell is constantly in cycle
6
Q
MAF
A
t(14;16)
Maf is a tranfscription factor
Deregulation of gene expression means cells are more susceptible to stress, and there is less regulation of cell divison
7
Q
What deletion is associated with MM?
A
Del 13q
Poor prognosis
