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MICROBIOLOGY 2.0 > Mycobacterium > Flashcards

Mycobacterium Flashcards

0
Q

Enzyme characteristic of m leprae

A

O-diphenoloxidase

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1
Q

First pathogen demonstrated in human tissue

A

M leprae

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2
Q

M leprae grows on Nutrient agar. True or false

A

False. Doesnt grow on any artificial medium. Obligate intracellular

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3
Q

M leprae causes systemic disease

A

False

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4
Q

They grow well above 30 degrees. M leprae

A

False

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5
Q

M leprae can be associated as an immediate cod

A

False

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6
Q

M leprae prefers hot surfaces of the body like axilla and groin

A

False

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7
Q

Basis for diagnosis of leprosy

A

Clinical manifestations

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8
Q

Nasal secretions of m leprae can survive for how long?

A

36hours

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9
Q

M leprae is HIGHLY infectious

A

False. Takes 3-4 years to have disease

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10
Q

Incubation period can last up to several years

A

True. 30 years

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11
Q

Animal used for research in leprosy

A

Armadillo

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12
Q

Most infectious source of m leprae

A

Nasal discharges

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13
Q

Immediate forma of leprosy

A

Borderline

Intermediate

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14
Q

BI measures what

A

Bacterial load

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15
Q

MI measures what

A

Bacterial viability

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16
Q

Mainstay drug for leprosy

A

Dapsone. Clofazimin. Rifampin

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17
Q

Combination therapy

A

1-2 years

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18
Q

Sign of restoration of CMI after onset of treatment

A

Erythema nodosumleprosum ENL

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19
Q

Multiple nodular lesions in the face

A

Leonine facie

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20
Q

Deficient CMI

A

Lepromatous

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21
Q

High levels of IL 4 and 10

A

Lepromatous

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22
Q

Diagnosis requires AFB stain, foam cells and false positive syphilis

A

Lepromatous

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23
Q

A granuloma is sufficient for diagnosis

A

Tuberculoid

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24
Q

Exam for sub clinical infxn of leprosy

A

Lepromin skin test

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25
Q

Lepromatous tests positive on lepromin st

A

False. Tuberculoid

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26
Q

Single lesion tx

A

ROM

Rifampin
Ofloxacin
Minocycline

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27
Q

Scrapings must be stained with?

A

Ziehl Neelsen

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28
Q

Serologic tests are valuable

A

False. No effect

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29
Q

This causes Buruli cancer

A

M ulcerans

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30
Q

Classified as a scotochromogen

A

M scrofulaceum

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31
Q

MOTT grows at 41 degrees

A

MAC or MAI

32
Q

Grows at 37 degrees MOTT

33
Q

Photochromogen

A

Kansaii. Group I

34
Q

Grows rapidly non pigmented

A

M fortuitum

35
Q

Has niacin

A

TB COMPLEX

36
Q

DOC for group 4

A

F-DA

DOXY
AZITHRO

37
Q

Prophylaxis for MAI

38
Q

Initial tx for MAC

A

ACE

Azithro
Clarithro
Etham

39
Q

Maintenance for MAC

A

For life. RAF-C

Rifabutin
Azithro
Fluoro
Clarith

40
Q

MOTT occuring to those with prosthetic hip joint and indqelling catheters

A

M fortuitum

41
Q

Only tx is removal of lymph node

42
Q

How to prevent leprosy spread

A

Isolate ALL

43
Q

Sudden asymmetric nerve involvement

A

Tuberculoid

44
Q

High CMI

A

Tuberculoid

45
Q

What makes m tubercle acid fast

A

High lipid content of cell wall

46
Q

They are obligate pathogen. M tubercle

47
Q

They are non pathogen common in smegma

A

M smegmatis

48
Q

This stain creates rods red in blue background

A

Ziejl neelsen

49
Q

Culture of m tubercle

A

Small, scaly dry corrugated surfaces

50
Q

Are m tubercle killed by heat

51
Q

How long does m tubercle in putrefying sputum lives. In dried?

A

Weeks 6-8 mos

52
Q

M tubercle are difficult to disinfect. Use what

53
Q

M tuerculosis and bovis are equally pathogenic to man

54
Q

More potent than PPD

A

Seibert proteins A an B

55
Q

Virulence factor of TB

A

Serpentine cord

56
Q

Avirulent culture

A

Random Brush heap patter

57
Q

His causes serpentine cord formation

A

Trehalose dimycolate

58
Q

Primary lesion of TB

A

Lower lobes

59
Q

Secondary lesions

60
Q

Define CATEGORIES OF TB

A 
0 no exposure
1 exposed
2 tb infxn
3 current tb dse
4 previous tb dse
5 tb suspect
61
Q

What causes night sweats in tb

A

tnf release

62
Q

Define reinfection from relapse

A

Diff strain. Same strain

63
Q

Solid medium culture

A

Lowenstein-jensen

64
Q

Liquid medium

A

Middlebroom

65
Q

How many specimens must be collected?

A

2x consecutive days

66
Q

Define ghon complex

A

Parenchymal exudative lesion plus draining lymph node

67
Q

Define tb inactive

A

Dormant org persist but no longer actively multiplying

68
Q

Doubling time o m tubercle

69
Q

Common age bracket affected with TB

A

2 years old above

70
Q

Molecular dx for better indication o mycobacterial cell viability

A

Rna and Mrna

71
Q

Stain used in ziehl neelsen

A

Carbolfuschin

72
Q

Destroys other undesired organism in a culture of m tubercle

73
Q

Reading of PPD

74
Q

This vaccine does not prevent having the dse but prevents the complications

75
Q

Mutation on pyrazimindase

76
Q

Mut on katG

77
Q

Mut on rpoB

A

Rifampicin

78
Q

Beta subunit of the DNA dependent RNA polymerase mutation

A

Rifampicin

MICROBIOLOGY 2.0 (7 decks)

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