mutations Flashcards
1
Q
Tumor suppressor genes
A
mutation leads to loss-of-function
TP53
PTEN
APC
2
Q
Oncogenes
A
mutation leads to gain-of-funtion KRAS EGFR BRAF IDH1
3
Q
Driver mutations
A
growth or survival advantage
needed for phenotype
mutation in TSG or oncogene
4
Q
Passenger mutation
A
neither advantage or disadvantage
random mutations
5
Q
proto-oncogenes
A
contain s normal cellular gene
become oncogenes once activated
6
Q
coding mutations
A
lead to abnormal proteins
7
Q
regulatory mutations
A
lead to excessive amounts of proteins
8
Q
translocation
A
leads to novel proteins
9
Q
gene amplification
A
leads to excessive amounts of proteins
