Musculoskeletal system Flashcards
Azathrioprine Ciclosporin Cyclophosphamide Leflunomide Penicillamine Methotrexate Gold
Are all seen in which condition?
These are the DMARDs used in Rhumatoid arthritis
Hydroxychloroquine is indicated for active rhumatoid arthritis. What is a big warning with this drug?
Screening for ocular toxicity is required- monitor visual symptoms during treatment
What drugs are used in the treatment of Gout?
Colchicine
Allopurinol
sulfinpyrazone
febuxostat
What severe hypersensitivity reaction has been associated with Febuxostat use?
Steven Johnsons syndrome
Stop immediately if steven johnsons ulcer like rash occurs
Why must we avoid abrupt withdrawal with Baclofen?
Risk of hyperactive state- hyperthermia, psychiatric reactions, convulsion. Dose should be discontinued gradually over 1-2 weeks
What should patients on Baclofen be advised with regards to driving?
Baclofen may cause drowsiness
What is baclofen used for?
Pain of muscle spasms in palliative care
Hiccups in palliative care
Muscular sclerosis etc
What are Aceclofenac, Acemetacin, Celecoxib, Etodolac, Felbinac Indometacin Mefenamic acid All examples of?
NSAIDs
Why have restrictions on the use of Piroxicam been put forward?
Increased risk of Gastro-intestinal side effects and of serious skin reactions.
Should not be used first line
Should be initiated by a specialist
Should only be used for rheumatoid arthritis not for pain anymore
(this guidance does not effect topical preps only oral)
What is the big safety warning with TIAPROFENIC ACID (an NSAID)?
It can cause SEVERE CYSTITIS
DO NOT give to patients with UTI disorders!
Stop if symptoms develop- increased frequency, nocturia, urgency, pain on urination, blood in urine.
Etanercept adalimumab Liximab Certolizumab Golimumab Infliximab
What are all these used in?
Rhumatoid arthritis
Chrons
Ulcerative colitis
‘Cytokine Modulators’
What should patients taking Cytokine Modulators be advised to look out for?
Etanercept adalimumab Liximab Certolizumab Golimumab Infliximab
TUBERCULOSIS:
(they’re immunosuppressant so infection with TB more likely)
Signs: persistent cough, Hemoptysis (coughing blood), weight loss
BLOOD DISORDERS:
agranulocytosis: fever, sore throat, bruising, bleeding
Which NSAID carries the lowest risk of CV effects?
Naproxen
Which NSAID carries the lowest risk of Gastro-intestinal side effects?
Ibuprofen
