Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Step 2 > Musculoskeletal and Rheumatology > Flashcards

Musculoskeletal and Rheumatology Flashcards

1
Q

What are the mechanism and ADRs of methotrexate?

A

MOA: Folate antimetabolite

ADR: Hepatotoxicity, Stomatitis, Cytopenias

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the mechanism and ADRs of Leflunomide?

A

MOA: Pyrimidine synthesis inhibitor

ADR: Hepatotoxicity, Cytopenias

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are the mechanism and ADRs of Hydroxychloroquine?

A

MOA: TNF & IL-1 suppressor

ADR: Retinopathy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are the mechanism and ADRs of Sulfasalazine?

A

MOA: TNF & IL-1 suppressor

ADR: Hepatotoxicity, Stomatitis, Hemolytic anemia ([S]ulfasalazine [S]lices)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What are the class/mechanism and ADRs of adalimumab, certolizumab, etanercept, golimumab, infliximab?

A

TNF inhibitors

ADR: Infection, Demyelination, Congestive heart failure, Malignancy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Which stage of Lyme disease?

- Erythema migrans, fatigue, headache, myalgias, arthralgias

A

Early localized

days to 1 month

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Which stage of Lyme disease?
- multiple erythema migrans, unilateral/bilateral CN palsy (eg, CN VII), meningitis, carditis (eg, AV block), migratory arthralgias

A

Early disseminated

weeks to months

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Which stage of Lyme disease?

- arthritis, encephalitis, peripheral neuropathy

A

Late

months to years

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q
  • Asian or Middle Eastern descent
  • Painful oral/genital ulcers is association with erythema nodosum-like lesions of the skin
  • Ocular lesions (e.g. anterior uveitis, blindness)
A

Behçet Syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Rheumatologic Condition:

  • RA-like symptoms or hx of RA
  • Splenomegaly
  • Neutropenia/recurrent infections
A

Felty Syndrome (“Felt” my splenomegaly)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is the difference between Systemic Sclerosis and CREST?

A

A spectrum of disease:
CREST = Calcinosis, Raynaud’s Esophageal Dysmotility, Sclerodactyly, Telangiectasia

When the above also involves the lungs, heart, and kidney it is scleroderma (a.k.a. systemic sclerosis)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are the features of systemic sclerosis?

A

All of the features of CREST in addition to:

  • Skin: Fibrosis of the hands, face, neck and extremities
  • GI: GERD, diverticuli, diarrhea
  • Renal: hypertensive crises
  • Lung: fibrosis leading to restrictive lung disease and pulmonary hypertension
  • Cardiac: myocardial fibrosis, pericarditis, and heart block, RVH
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Pituitary irregularities
Parathyroid
Pancreatic islet cells

A

“Three P’s” = MEN1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Medullary thyroid carcinoma
Pheochromocytoma
Parathyroid

A

“Two P’s” = MEN 2A

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Mucosal neuroma/Marfanoid habitus
Medullary thyroid carcinoma
Pheochromocytoma

A

“One P” = MEN 2B

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Porphyria Cutanea Tarda

A

Blistering of sun-exposed skin in patients with a history of liver disease (e.g. Hepatitis C, alcoholism), estrogen use or iron overload (hemochromatosis)

17
Q

Condition presenting with:
Fever
GI symptoms: severe abdominal pain, nausea, vomiting
Neurological abnormalities
Polyneuropathy: non-specific pain, weakness/fatigue, paresthesia, paresis
Seizures
Psychiatric abnormalities: hallucinations, disorientation, anxiety, insomnia
Autonomic dysfunction: tachycardia, hypertension
Red-purple urine
No skin involvement

A

Acute Intermittent Porphyria

18
Q

Anti-CCP Ab is specific for?

A

RA

19
Q

Anti-dsDNA and anti-Sm antibodies are specific for?

A

SLE

20
Q

Anti-histone Ab is specific for?

A

Drug-induced lupus

think: histone like “hist”amine –> IgE response to drugs

21
Q

Anti-Scl-70 Ab is specific for?

A

Systemic sclerosis

22
Q

Anti-[c]entromere Ab is specific for?

A

Limited ([c]utaneous) systemic sclerosis ([C]REST)

23
Q

Anti-Jo-1 Ab is specific for?

A

Polymyositis/Dermatomyositis

24
Q

Patient presents with Raynaud phenomenon, hand/finger swelling, arrthritis/synovitis, inflammatory myopathy, pulmonary hypertension, malar or discoid rash, and mild CNS and/or renal disease.

A

Mixed Connective Tissue Disease = overlap of SLE, scleroderma and polymyositis

25
Q

Anti-U1 ribonuclear protein (RNP) is specific for?

A

Mixed Connective Tissue Disease

Step 2 (12 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions