Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Step 2 > Hematology and Oncology > Flashcards

Hematology and Oncology Flashcards

1
Q

When working up anemia with equivocal B12 and folate levels, what measure can be used to help you determine the true etiology?

A

Methylmalonic acid (MMA). MM a is elevated in B12 deficiency

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

A patient presents with a normocytic anemia, with a high LDH, low haptoglobin, and increased total bilirubin. What is the most likely etiology of their anemia?

A

These labs indicate hemolysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Reticulocyte index < 2%

A

Production Anemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Reticulocyte index > 2%

A

Destruction Anemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

How does alpha thalassemia compare to Beta thalassemia on smear?

A

In Alpha: the beta subunit can only bind with alpha subunits. Therefore, whatever alpha is made (even if it’s just a little bit) will bind with beta. The smear will appear normal

In Beta: the alpha subunit can bind with any type of chain. Therefore you will see alpha combined with non-beta subunits.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

cALLA and Tdt markers

A

Acute Lymphocytic Leukemia (ALL)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Leukemia in patient with median age 7

A

ALL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Leukemia in patient with median age 47

A

CML

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Leukemia in patient with median age 67

A

AML

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Leukemia in patient with median age 87

A

CLL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Patient with angioedema, hypotension, respiratory distress/wheezing, shock within seconds to minutes of receiving a blood transfusion.

A

Anaphylactic - Recipient anti-IgA antibodies directed against donor blood IgA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Patient with fever, flank pain, hemoglobinuria, DIC and

positive Coombs test, within 1 hour of receiving a blood transfusion.

A

Acute hemolytic - ABO incompatibility (often clerical error)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Patient with fever & chills within 1-6 hours of receiving a blood transfusion.

A

Febrile nonhemolytic - Cytokine accumulation during blood storage

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Patient with urticaria within 2-3 hours of receiving a blood transfusion.

A

Urticarial - Recipient IgE against blood product component

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Patient presents with respiratory distress and noncardiogenic pulmonary edema with bilateral pulmonary infiltrates within 6 hours of receiving a blood transfusion.

A

Transfusion-related acute lung injury (TRALI) - Donor anti-leukocyte antibodies

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Patient is asymptomatic, with laboratory evidence of hemolytic anemia and positive Coombs test, positive new antibody screen, within days to weeks of receiving a blood transfusion.

A

Delayed hemolytic - Anamnestic antibody response

17
Q

Patient with rash, fever, gastrointestinal symptoms, pancytopenia within weeks of receiving a blood transfusion.

A

Graft versus host - Donor T-lymphocytes

Step 2 (12 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions