Musculoskeletal Flashcards
Reiter’s syndrome
Acute (reactive) arthritis
Conjunctivitis
Non-specific urethritis
Can’t see, can’t pee, can’t climb a tree
HLA-B27
Psoriasis
Can mimic RA Psoriatic skin and nail changes Asymmetrical arthritis (DIP) +/- sacroiliitis
Felty’s syndrome
Rheumatoid disease + splenomegaly
Splenomegaly –> pancytopenia + recurrent infex
anti-dsDNA
SLE
anticentromere
systemic sclerosis
anti-Scl-70
diffuse cutaneous systemic sclerosis
anti-Jo-1
dermatomyositis
c-ANCA
Wegener’s granulomatosis
p-ANCA
PAN, AI hepatitis, IBD, sclerosing cholangitis
anticardiolipin
antiphospholipid syndrome
anti-La/anti-Ro
Sjoegren’s syndrome
GCA
Unilateral headache, scalp tenderness, jaw claudication, vision loss and PMR
Takayasu’s
Young japanese women, weak distal pulses, arm claudication
PAN
HepB, renal/mesenteric/skin involvement
Rosary sign on renal angiography
Kawasaki’s
Conjuctivitis rash Arthralgia Strawberry tongue Oedema Fever
Ankylosing spondylitis
Affects YOUNG people, chronic back pain, sacroiliitis, uveitis
++ ESR/CRP
****HLA-B27 90% specific
***x-ray = flattening of the lumbar curve with subchondral bone erosion involving the sacroiliac joints
TREAT with NSAIDs
Diagnostic criteria for diagnosing rheumatoid arthritis
Morning stiffness (>1 hour for 6+ weeks)
Arthritis in 3+ joints (>6 weeks)
Arthritis of hand joints (>6 weeks)
Symmetrical arthritis (>6 weeks)
Rheumatoid nodules
Positive rheumatoid factor
Radiographic changes
Jones criteria - major manifestations
Diagnosing RHEUMATIC FEVER
Carditis Polyarthritis Chorea Erythema marginatum Subcutaneous nodules
Jones criteria - minor manifestations
Diagnosing RHEUMATIC FEVER
Fever
Arthralgia
Previous Hx rheumatic fever/heart disease
What are the clinical features of Paget’s disease of bone?
Deep, boring pain Gout Heat Bone expansion + deformity (pelvis/lumbar spine) Fractures Neurological Sx High output cardiac failure
What would you expect to see when investigating Paget’s disease of bone?
Alkaline phosphatase ++++++
Also plain x-ray / bone scan
