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Pmy2107 > Musculoskeletal > Flashcards

Musculoskeletal Flashcards

1
Q

NSAIDS pharmacological actions

A

Lower temps
Analgesic effects
Anti inflammatory effect

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2
Q

How long until there is a full anti inflammatory effect with NSAIDS

A

Up to 3 weeks

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3
Q

What does NSAIDS inhibit

A

COX enzymes

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4
Q

Short half life NSAIDS

A

Half life less than 6 hrs

Ibuprofen

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5
Q

Long half life NSAIDS

A

Half life usually < 6 hrs
Eg naproxen
Dose usally twice daily

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6
Q

Interactions with NSAIDS (6)

A

Oral anticoagulants eg warfarin - all NSAIDS have an anti platter effect so can increase the effect of anti coagulants

Hypotensive agent ( decrease hypotensive effect)

ACE inhibitors and angiotensin 2 antagonists ( ⬇️ hypertensive effct ⬆️ risk of renal impairment )

Diuretics (⬇️ diuretic effect)

Lithium (⬇️excretion - toxicity potential )

Methotrexate (⬇️excretion - toxicity potential )

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7
Q

What prostaglandin synthase enzymes are responsible for gastric muscosa function

A

PGE2 AND PGI2

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8
Q

What prostaglandin synthase enzymes are responsible for renal function

A

PGE2

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9
Q

What prostaglandin synthase enzyme is responsible for platelet function

A

TXA2

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10
Q

NSAID side effects (5)

A

GI Complications

Reversible renal failure

Platelet dysfunction

Bronchospasm - can worsen asthma in some patients

Skin reactions

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11
Q

What does cox2 cause excessive production of in the rheumatoid joint

A

IL-1
TNFs
Growth factors

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12
Q

COX 1 important physiologic function

A

Stomach mucosal protection

Thromboxane in platelets

Kidney modulating intrarenal blood flow and electrolyte balance

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13
Q

COX-1 specific inhibitors

A

Low dose aspirin (used for anti platelet therapy )

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14
Q

NON specific cox inhibitors

A

Diclofenac

Ibuprofen

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15
Q

Preferential COX-2 inhibitors

A

Etodolac

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16
Q

COX 2 specific inhibitors

A

Celecoxib (1st gen)

Etoricoxib (2nd gen)

17
Q

Where are opioid receptors found in high concs

A

Brain
Spinal cord
Periphery eg guts , lungs

Pmy2107 (11 decks)

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