Muscles and Muscle Tissue Flashcards
What are the four general functions of the muscular system?
- Producing movement -
* skeletal - responsible for locomotion (movement of the body) and manipulation (movement of body parts)
* cardiac- beating helps blood course through your body
* smooth - maintains blood pressure and propel substances through organs & along the tract - Maintaining posture - skeletal system makes partial muscle contractions to counteract gravity
- Stabilizing joints - when pulling on bones for movement, they strengthen and stabilize the joints of the skeletons.
- Thermogensis (generate heat) - when muscle contracts they generate heat (when you exercise too.)
Classify the three types of muscle tissue (according to location, appearance, and type of nervous system control).
Skeletal - LONGEST MUSCLE CELLS, striated, VOLUNTARY
Cardiac - striated, involuntary, cardiac
Smooth - NONSTRAITED, involuntary, in walls of visceral organs
ex: dilates and constricts pupils , forms arrector pili muscles in hair follicles
Name and describe the four functional characteristics of muscle.
Excitability (responsiveness) - Ability of a cell to receive and respond to a stimulus by changing its membrane potential. (stimulus is usually chemical like a neurotransmitter released by a nerve cell.)
NERVOUS TISSUE IS MOST EXCITABLE
Contractibility - ONLY IN MUSCLES (the ability to forcibly shorten when adequately stimulated)
Extensibility- Ability to extend or stretch (when relaxed) *protective characteristic
Elasticity- The ability of a muscle cell to. recoil and resume its resting length after stretching *protective characteristic
Which of the above properties (#3) is muscle’s most distinguishing, or unique, characteristic?
contractibility
Which of the above properties (#3) are protective?
extensibility, elasticity
Describe the gross anatomy of a muscle, beginning with the myofibrils.
MUSCLE (covered by Epimysium)
- — fascicles (portion of the muscle) (covered by perimysium)
- —- made of…. muscle fibers (covered by endomysium)
- —– made of myofibrils
skeletal muscle also has:
rich nerve and blood supply
Name the CT sheath that surrounds individual muscle fibers. Of what type of CT is this sheath
composed?
endomysium , AREOLAR CT
. Name the CT sheath that surrounds a fascicle. Of what type of CT is this sheath
composed?
perimysium ; dense IR CT
Name the CT sheath that holds multiple fascicles together to create a muscle. Of what type of
CT is this sheath composed?
Epimysium ; dense CT
Describe the difference between indirect and direct muscle attachments
Direct (fleshy attachments) - binds directly to bone ; the epimysium of the muscle is fused to the periosteum or perichondrium
Indirect - Anchors muscle to the CT covering of a bone ; Muscle CT wrapping extends beyond muscle as either a tendon (ropelike) or aponeurosis (sheetlike)
Name and compare the two types of indirect muscle attachments.
tendon (ropelike)
aponeurosis (sheetlike)
Relative to muscle function, can you describe the significance of Sharpey’s fibers (i.e.,
perforating fibers)?
It connected tendons etc to the periosteum of bone
Name and describe the four arrangements of fascicles/fibers within skeletal muscles.
- circular, - arranged in concentric rings (close when contracting)
Ex: orbicularis muscles surrounding the eyes and the mouth
- convergent - its fascicles converge towards a single tendon of insertion (has a triangular tip)
- parallel- the length of the fascicles run parallel to the long axis of the muscle
- pennate - short and attach obliquely to a central tendon that runs the length of the muscle (all shaped differentl but have a blunt point)
What is the advantage of the parallel arrangement of fibers? of the pennate
arrangement? the convergent?
The more parallel the muscle arrangement is, the more the muscle can contract but not very powerful ;
pennate - they have more muscle fibers making them more powerful.
convergent - allow muscles to cover broad surfaces
What benefit is provided by a lever that operates at a mechanical advantage? at a
mechanical disadvantage?
Power levers, a large load is moved only a small distance but the effort required is small if the load is farther from the fulcrum and the fulcrum is closer to the effort then then thats a mechanical disadvantage because the effort has to be greater.
What is the most common class of lever system in the in the body? Where is the fulcrum with respect to the load and effort in this lever system?
The third class lever ; the effort (applied force) is between the load and the fulcrum.
when you flex with a weight and the effort does to your brachial not your antebrachiel or antecubital
What is the function of myoglobin?
stores and transfers O2 from the blood to the mitochondria.
What is the most prevalent chemical compound (by weight) in muscle?
ATP
Describe how the following organelles are modified or adapted for function in skeletal
muscle tissue: nucleus; mitochondria; smooth endoplasmic reticulum.
Nucleus - Involved in regulating protein synthesis
Mitochondria - muscle contracts require a lot of ATP
smooth ER - forms a tubular network around individual myofibrils.
- regulated conc. of intracellular Ca2+ , send Ca2+ to sarcoplasm
What gives skeletal muscle fibers a striated appearance?
the thin and thick filaments overlapping each other
What causes each of the bands, zones, and lines in a myofibril?
LEFT TO RIGHT
Z disc - a single sarcomere extends from one Z to the next; marks the boundary between one sarcomere and the next
— composed of elastic filaments compounds that are made of TITIN (protein) ; they hold thick filaments in place and give them elasticity
I band - light area because its thin filaments only
A band - dark area because thats where the thin and thick filaments over lap
- —- H zone - thick filaments only
- —— M line in H zone (thick filaments linked by accessory proteins)
What is a sarcomere?
the contractile unit compounds of myofilaments
What is the function of the Z disc?
marks the boundary between one sarcomere and the next
Identify the two primary types of myofilaments found in myofibrils.
THICK - made of myosin
-rod like tail with a globular head
THIN - made of actin
- made of blueberry looking G actin made into a line called F actin and held together by regulatory proteins
Describe the structure of a myosin molecule. How are myosin arranged to make up a thick filament?
consists of a rod-like tail with a globular head , to forms a thick filament, the myosin molecules are packed together protrude at the opposite ends of the filament.
Identify the proteins which make up thin filaments.
Actin (small G actins make long F actin strands) , troponin and tropomyosin
Which of the proteins identified above in thin filaments is/are regulatory proteins and their functions?
troponin -attaches to a G protein (hold tropomyosin over active site ad positions it on actin)
- binds calcium ions
tropomyosin - reshaped protein
- polypeptide strands
- helps stiffen and stabilize
- prevents tick filament from binding to thin ones
Describe the structure of an actin molecule. How are individual actin monomers
arranged to make up a thin filament?
G actin - blueberry looking come together to form F actin that if held by tropomyosin and troponin attaches to the active site in the G actin
Which protein covers the active sites on the actin filament in a resting muscle fiber?
troponin
Describe the location of the sarcoplasmic reticulum (SR) with respect to the myofibrils.
It forms a tubular network around individual myofibrils
What is the function of the SR and the terminal cisternae?
regulate muscle contraction (intracellular levels of ionic calcium) ; it stores calcium and releases it on demand when the muscle fiber is stimulated to contract
What is the significance of the Ca2+-release channels and the Ca2+ active transport pumps
in the SR?
sends calcium to the sarcoplasm
What are the T tubules? Where are they located?
(transverse)-tunnel ;
tunnel-like invaginations (cavity or pouch) of the sarcolemma
at each A band-I band junction
What is the function of the T tubules?
They conduct impulses to the deepest regions of the muscle cell and every sarcomere.
These impulses trigger the release of calcium from the adjacent terminal cisterns.
Its like a messaging system that makes sure every myofibril contracts at the same time
Why is the triad of functional significance?
it is made of 1 T tubule and 2 terminal cisterna
has integral proteins that extend into the inter membrane space and acts as voltage sensors
proteins are also receptor that regulate the release of calcium from the SR
What causes Ca2+ to be released from the terminal cisternae?
action potential (electrical impulses that send signals around your body)
triggers voltage sensors
Muscle contraction is currently best described by the sliding filament theory. Why is this
name appropriate for the contraction process?
During contraction, the thin filaments slide past the thick ones so that the actin and myosin filaments overlap to a greater degree
What happens to the A band, I band, H zone, and Z discs during contraction? to
sarcomere length?
A band - doesn’t change its length because thick filaments determine its length.
I band - shortens
H zone- disappears because thats the space outside the m line, if the filaments pull in, it disappears.
Z Discis- distance between the two discs shorten
What is the role of Ca2+ and the regulatory proteins in the sliding filament mechanism?
calcium levels have to be elevated so that the nervous system can stimulate the muscle fibers (send nerve impulses/ action potential) , calcium binds to troponin changing the shape of tropomyosin and exposing the actin sites that myosin attaches to for muscle contraction.
Specifically, how do troponin and tropomyosin help regulate the contraction process?
Once calcium levels get low, tropomyosin blocks the active sites on actin and troponin pulls tropomyosin off of the active site.
What is the role of ATP and the myosin head in the sliding filament mechanism?
atp causes the myosin head to cock and attach to the actin binding site