Muscle anatomy and physiology Flashcards

1
Q

what is the order of structures in a muscle

A

whole muscle –> fascile –> fibre –> myofibril –> sarcomere

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2
Q

what is the difference between the epimysium, perimysium, and endomysium

A

epimysium = surrounds muscle
perimysium = surrounds fascicles
endomysium = surrounds fibres

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3
Q

what is a fusiform muscle

A

almost parallel fibres to the line of action
ex: biceps brachii

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4
Q

what is a unipennate muscle

A

one pennation angle
fascicles stick in to aponeuroses on the side
ex: medial gastroc

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5
Q

what is a bipennate muscle

A

two pennation angles
have internal aponeurosis/tendon (connection point) where the fascicles connect
ex: tibialis anterior

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6
Q

what is the difference between pennation angle and line of action

A

pennation angle = angle at which the fibres are oriented to the muscles line of action
line of action = line drawn between each tendon, axes at which the muscle would contract along

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7
Q

what parts of the muscle stay the same or change during contraction

A

stay the same = muscle volume
change (depends) = thickness, length, width, pennation

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8
Q

what is an aponeurosis

A

continuation of distal and proximal tendons
like a sheath over the muscle
collagen fibrils more randomly arranged than in tendon (in longitudinal direction)
results in greater longitudinal stiffness

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9
Q

where do the aponeuroses come from in the medial gastroc

A

deep aponeurosis = continuation of distal / achilles tendon
superficial aponeurosis = continuation of proximal tendon

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10
Q

how does the aponeurosis behave

A

heterogenous behaviour during contraction
can see changes and stretching in all directions
different regions behave differently

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11
Q

how are forces applied to the aponeurosis different

A

more complex and multidirectional
results in multidirectional deformations / strains

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12
Q

what is a muscle fibre defined as

A

single cell that is formed during development from the fusion of several undifferentiated immature cells (myoblasts)

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13
Q

what is the ECM in muscle

A

includes endo, peri, and epimysium
collagen is the major structural protein in ECM
- accounts for ~10% of muscle dry weight

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14
Q

what is the effect of ECM on the function of muscle

A

lot stiffer than fibres so overall stiffness of fibre bundles / fascicles is much higher
muscle is much stiffer when the connective tissue is present

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15
Q

what are myofibrils

A

composed of repeating units of sarcomeres which give them a characteristic striation pattern
(striated muscle)

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16
Q

what is the smallest functional unit of muscle

A

sarcomeres

17
Q

what are the Z lines in muscle

A

defines outer bounds of each sarcomere
attachment of actin / thin filaments
appears as dark lines on electron micrograph

18
Q

what is the A band

A

length of myosin / thick filament
has overlap with actin filaments
referred to as anisotropic band due to how it polarises light under an electron micrograph

19
Q

what is the I band

A

region of only actin filaments
referred to as isotropic band due to how it does not polarise light
(no directional dependence in filtering)

20
Q

what is the M line

A

where myosin tails connect (mid line)

21
Q

what is the H zone

A

where only myosin is present

22
Q

what are the different types of proteins in sarcomeres

A

actin / myosin (66% of myofilament proteins)
troponin / tropomyosin
titin
^^ 85% of total protein amount
nebulin and alpha actinin
myomesin and c-protein

23
Q

what is the difference between troponin and tropomyosin

A

troponin = complex of 3 regulatory proteins (I, C, T)
tropomyosin = scaffold that maintains alignment and structure of thin filaments
both = involved in cross bridging

24
Q

what is the function of titin

A

largest protein found
structural protein
links thick filaments to Z disc

25
Q

what do nebulin and alpha actinin do

A

orient actin

26
Q

what do myomesin and c-protein do

A

keeps tails of myosin filaments aligned