Multisystemic Dz - Ag

Question 1

Acute BVDV & Dx

Answer 1

Young naive calves (6mo-2yrs)
- these guys are immunocompetent

See blunting of papilla on tongue

Dx: pcr or serology
- these guys are shedding a lot in the acute phase

Question 2

Persistent BVDV & Dx

Answer 2

PI = Fetal infection at <125 days gestation with NCP

Dx: Ear notch - Ag capture ELISA or IHC
- these guys are always shedding

Question 3

Mucosal BVDV & Dx

Answer 3

PI animal becomes infected with CP virus or molecular rearrangement/mutation of NCP to CP

**SEVERE epithelial erosions/ulcerations! This dz is BAD

Dx: CS, PCR, and serology (variable), necropsy

Question 4

What would you do if you find a BVDV PI?

Answer 4

50% die within 1st year of life

But should cull positives

Question 5

Lepto!
Pathogenesis?
Symptoms?
Tx?

Answer 5

Pathogenesis:
- shed in high conc in urine –> contact with urine –> penetrates mm or compromised skin –> incubation 3-7 days –> shed before CS appear

CS:

• host-adapted (hardjo-bovis)
• signs assoc’d with affected organs from bacteremia, abortion, and EED
• non host-adapted
• Repro, hemolytic anemia (calves!), abnormal milk

Tx:
Long acting tetracycline
Supportive care

Question 6

Syndromes and assoc’d CS of Histophilus. How do we tx?

Answer 6

FEEDLOTS

CS:

• bronchopneumonia
• pleuritis
• otitis media
• TEME (“sleeper calves”)
• septic arthritis
• myocarditis

Tx:
Tetracycline

Question 7

Syndromes and assoc’d CS of Mycoplasma. How do we tx?

Answer 7

• mastitis
• resp dz/pneumonia
• otitis media
• arthritis
• tendonitis
• tenosynovitis

Tx: often frustrating

• if resp than Baytril
• can use Florfenicol

Question 8

When can we use enrofloxacin (Baytril)?

Answer 8

Only labeled for use in BEEF and NON-lactating dairy cattle with BRD assoc’d with Mannheimia haemolytica, Pasteurella multocida, Histophilus somni, and Mycoplasma

ILLEGAL to use extra-label

Question 9

BTV - CS and spp affected?

Answer 9

Vasculitis syndrome

• widespread epithelial necrosis
• endothelial damage (edema)
• High Fever, wool break, crusted muzzle, salivation, congenital defects, cyanosis of tongue (rare)

Sheep get CS

Cattle and goats rarely get CS

Wild ruminants can get CS

Question 10

MCF - CS and spp affected?

Answer 10

Highly fatal disease

• high fever
• generalized lymphadenopathy
• keratoconjunctivitis > edema starts at limbus

Ruminants and swine
- cattle, bison