multisystem inflammatory disorders

Question 1

what type of disease are connective tissue disease

Answer 1

polygenic autoimmune disease

Question 2

summarise antinuclear Ab

Answer 2

characteristic of connective tissue disease at low titre

common in population at low titre

detected by immunofluresence

Question 3

what are the ribonucleoproteins

Answer 3

Ro

La

Sm

U1RNP

Question 4

what is topoisomerase

Answer 4

SCL70

Question 5

summarise systemic vasculitis

Answer 5

inflammation of bv - usually arterial system

features of systemic inflammation - fever, malaise, wht loss, fatigue, myalgias, arthralgias

features of the vasculitis dependent on size/distribution of the vessels that are affected

Question 6

large vessel vasculitis

Answer 6

takayasu

GCA

they are polygenic autoinflammatory diseases

Question 7

medium vessel vasculitis

Answer 7

polyarteritis nodosa

kawaskai disease

Question 8

small vessel vasculitis

Answer 8

ANCA-associated vasculitis (Ab to neutrophils)

immune complex vasculitis

polygenic autoimmune disease

Question 9

mixed vessel vasculitis

Answer 9

bechet’s

Question 10

takayasu arteritis

Answer 10

affects aorta and major branches

subclavian = upper limb claudication

carotid = CNS disease

renal artery stenosis = increase in RAAS = HTN

common in young women, and from East. Increasing in older people and UK

high CRP and ESR