Multisystem diseases affecting kidneys

Question 1

Diabetic neuropathy- Eti

Answer 1

• 1/3 of pts with ESKD are due to DM II
• Type 1 have higher chance, but fewer pts total
• Higher mortality than non DM pts

Question 2

Diabetic neuropathy- Sx

Answer 2

• Proteinuria, urinary albumin due to hyperfiltration
• Urea & creatinine in blood
• ACEI & ARBs to reduce intraglomerular pressure
• Progress to nephrotic syndrome
• Edema, hyperlipidemia, azotemia

Question 3

Lupus nephritis- Eti

Answer 3

• Renal involvement of SLE
• 35-90% of SLE pts
• highest in non-whites

Question 4

Lupus nephritis

Answer 4

• Nephritic syndrome
• Hemat & protein uria
• Tx with immunosupressants

Question 5

Hypertensive nephropathy-

Answer 5

• Chronic HTN leads to nephrosclerosis
• Blacks
• Vascular disease of renal arteries
• Sclerosis of glomeruli

Question 6

Amloidosis

Answer 6

• Deposition of abnormally folded protein- Insoluble & fibers
• Proteinuria, decreased GFR & nephritic syndrome
• Enlarged kidneys

Question 7

Pulmonary renal syndrome

Answer 7

• Alveolar hemorrhage & glomerulonephritis

- due to autoimmune disorder

Question 8

Hepatorenal syndrome

Answer 8

• AKI due to liver cirrhosis

- Progresses into ESRD

Question 9

Renal artery stenosis

Answer 9

• Narrowing of renal arteries

- Due to atherosclerotic disease

Question 10

HIV nephropathy

Answer 10

Nephrotic syndrome with declining GFR in pts with HIV