Glomerular disorders Flashcards
1
Q
Nephritic syndrome
A
- Hematuria,
- proteinuria (<3g/d),
- RBCs & RBC casts
- HTN & volume overload
- Oliguria
- Rapid loss of GFR
2
Q
Nephrotic syndrome
A
- Marked proteinuria (> 3g/ day) albumin
- Few cells
- Foamy urine
- hypoalbuminemia,
- massive edema,
- hyperlipidemia,
- fat bodies in urine
3
Q
Postinfectious Glomerulonephritis- Eti
A
- Following pharyngitis or impetigo
- Viral, fungal, parasitic or bacterial
4
Q
Postinfectious Glomerulonephritis- Sx
A
Nephritic:
- Oliguria
- Hematuria
- < 3g/d proteins
- Edema
5
Q
Postinfectious Glomerulonephritis- Dx
A
- Biopsy: Immume complexes in mesangium, deposits or “humps”
- Low serum complement C3
- High ASO
6
Q
Postinfectious Glomerulonephritis- Tx
A
- Supportive, salt restriction, diuretics, anti-HTN
7
Q
Goodpasture syndrome- Eti
A
Nephritic syndrome:
- Males in 2nd/ 3rd decade
- Some assoc with pulm, tobacco
- Anti glomerular basement memebrane Abs
8
Q
Goodpasture syndrome- Sx
A
- Preceeded by URI
- Hemoptysis, dyspnea, resp. failure
- Hematuria/ proteinuria
9
Q
Goodpasture syndrome- Dx
A
- Sputum- macrophages
- CXR- pulm infiltrates
- Anti-GBM Abs
- Biopsy- IgG along GBM
- ANCA titers
10
Q
Goodpasture syndrome- Tx
A
- Plasma exchange tx
- Corticosteroids
11
Q
IgA Nephropathy- Eti
A
Nephritic syndrome:
- Most common glomerular disease in world- Asians!
- M > F, young > old
12
Q
IgA Nephropathy- Sx
A
- Gross hematuria associated with mucosal viral infection
- Red or cola colored urine
- Nephritic syndrome sx
13
Q
IgA Nephropathy- Dx
A
- Biopsy: Postive IgA
- Normal complement
- Gross hematuria
14
Q
IgA Nephropathy- Tx
A
- Low: monitor annually
- Med to high: ACE/ ARB, Immunosupressants
- Kidney transplant
15
Q
Henoch-Schönlein purpura- Eti
A
Systemic vasculitis- children
