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Rheum > Multiple Systems > Flashcards

Multiple Systems Flashcards

1
Q

What are the skin changes in lupus?

A 
Butterfly rash (spares nasolabial folds)
Discoid rash
Photosensitivity 
Non- scarring alopecia 
Livido
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2
Q

Antibodies in SLE

A

Ana

Anti Dsdna

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3
Q

Dry mucous membranes and joint pain?

A

Sjogrens

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4
Q

Anti bodies in sjogrens?

A

Ana
Ro
La
Rheumatoid factor

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5
Q

Signs and symptoms of limited cutaneous systemic sclerosis

A 
Calcinosis
Raynauds
Oesophageal dysfunction 
Scerodsctly
Telengiectasis 
(CREST) 
And pulmonary arterial hypertension
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6
Q

Antibodies in limited cutaneous systemic sclerosis?

A

Ana

Anti centromere antibody

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7
Q

Antibodies in diffuse systemic sclerosis

A

Ana
Anti- scl70
(Anti topoisomerase)

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8
Q

What are the features of diffuse scleroderma?

A

Lung (pulmonary hypertension), heart (right sided heart failure), GI and kidney (renal crisis: malignant hypertension, high renin, azotemia, microangiopathic haemolytic anaemia, haematuria/protienuria ) involvement

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9
Q

What is seen on bloods in antiphospholipid syndrome?

A

Paradoxical (Long) APTT

Low platelets

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10
Q

Which disease in AMA antibody associated with?

A

Primary biliary cirrhosis

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11
Q

Which cancers are associated with dermatomyositis?

A

Ovarian, breast, lung found in 20-25% of patients.

Needs investigations esp in older people.

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12
Q

What features are seen in bechets?

A 
Mouth and genital ulcers
Skin lesions (Erythema nodosum)
Opthalmic lesions (uveitis or retinitis)

Cerebral vasculitis (head, seizures)
Arthritis and IBD symptoms
Raised CRP and ESR

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13
Q

What is libman-Sachs endocarditis?

A

Sterile endocarditis associated with SLE

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14
Q

Anti- smith antibodies?

A

Pathopneumonic for SLE

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15
Q

Diffuse systemic sclerosis features

A

Pulmonary

Gut

Renal - Rx with ace and dialysis

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16
Q

Rx of Sjögren’s syndrome

A

Hydroxychloraquine
Pilocarpine

Plus lubrication
Monitor for lymphoma

17
Q

First line treatment for SLE ?

A

Hydroxychloroquine (good for mucocutaneous disease)

DMARDs for more aggressive disease

Rheum (14 decks)

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