multiple sclerosis

Question 1

name the condition

blurred vision and red desaturation

Answer 1

optic neuritis

Question 2

criteria for MS

Answer 2

mcdonald criteria

Question 3

what gets demylinated in MS

Answer 3

white matter

Question 4

what cells are affected in MS

Answer 4

oligodendrocytes

Question 5

genetic factor that contribute to MS

Answer 5

HLA DR2

Question 6

what is the ultimate outcome of the pathophysiology of MS

Answer 6

demyelination and axonal death

Question 7

what is seen on MRI imaging in MS

Answer 7

plaques due to scarring of oligodendrocytes

Question 8

what is the most common type of MS

Answer 8

relapsing remitting MS

Question 9

what is optic neuritis

Answer 9

inflammation of optic nerve

Question 10

what does uhtoff phenomenon suggest about MS

Answer 10

symptoms worsen following rise in temp e.g. hot bath

Question 11

what type of signs does MS present with

UMN
LMN

Answer 11

UMN signs

problem in CNS

Question 12

what is lhermittes phenomenon in MS

Answer 12

flex neck = electric shock sensation down spine

Question 13

what is intranuclear opthalmaplegia

Answer 13

when looking in direction one moves but other eye stays still

Question 14

what is responsible for intranuclear opthalmaplegia

1. demyelination of dorsal longitudinal fasiculus
2. demyelination of medial longitudinal fasiculus

Answer 14

2. demyelination of medial longitudinal fasiculus

Question 15

what is an important investigations needed in Ms

Answer 15

MRI brain and spine

Question 16

what is used to treated a relapse/acute of MS

Answer 16

methylprednisolone

Question 17

what meds can be given to reduce rate of relapse

Answer 17

DMARD