Multiple Sclerosis Flashcards
immune mediated destruction of CNS w/ secondary loss of axons
MS
classic MS lesion
demarcated white matter plaques, have a periventricular prominence
initial step in pathogenesis
lymphocytes and macs penetrate BBB
MS vs other leukodystrophies (demyelinating dzs)
MS gives autoimmune destruction of myelin
leukodystrophies have abnl myelin produced (defective synthesis)
MS affects people from what location
born and raised in temperate latitudes or global zones father from the equator (maybe related to lower vit D levels?)
“risk factors” for MS
genetically susceptible
exposure to triggering factors (maybe virus)
live in temperate zones
amount of inc risk for siblings of MS patient
20-fold inc risk
MS population
young adults 20-40 y/o
F:M ratio for MS
2:1
first course of MS
80% relapsing-remitting
20% primary progressive
2nd phase for MS pts who started relapsing-remitting
secondary progressive phase - less recovery
primary progressive MS pathogenesis
different from relapsing-remitting type, doesn’t respond well to immunomodulators
cause of death for MS
infection, malnutrition, and pulm emboli –> complications of immobility
initial sxs of MS
optic neuritis, sensory/motor deficits in lower limbs, internuclear opthalmoplegia
MLF lesion
aka internuc opthalmoplegia - blurry vision/diplopia