Mucormicosi

Question 1

Definizione

Answer 1

rare fungal infection, primarily affecting immunocompromised patients and patients with diabetes mellitus

Question 2

Eziologia

Answer 2

: fungi of the order Mucorales, most commonly Rhizopus oryzae; ubiquitous fungi found in vegetation and soil

Question 3

Clinica

Answer 3

▫Rhino-orbital-cerebral mucormycosis: the most common form; presents with sinusitis, fever, headache

▫Pulmonary mucormycosis: aggressive infection of the bronchioli and alveoli, presenting with fever and hemoptysis

▫Disseminated mucormycosis: (rare) invasion of the vasculature with subsequent dissemination; may affect any organ

Question 4

Fisiopatologia

Answer 4

Inhalation of the spores into the nose and maxillary sinus (diabetic ketoacidosis stimulates fungal growth) causes sinusitis, tissue necrosis, and contiguous spread to the orbit, brain, and palate. Inhalation of the spores into the pulmonary system may lead to contiguous spread to the mediastinum and heart.

Question 5

Diagnosi

Answer 5

BIOPSIA

Question 6

Trattamento

Answer 6

AMFOTERICINA B