MTB 5 (Endo, Infectious) Flashcards

1
Q

Common findings in Infants of DM mothers

A

Macrosomia
Small Left Colon Syndrome
Cardiac abnormalities
Renal Vein thrombosis

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2
Q

Metabolic findings in IDM

A

Hypoglycemia
Hypocalcemia
Hypomagnesemia
Hyperbilirubinemia

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3
Q

Cardiac changes in IDM and management

A

Asymmetric septal hypertrophy due to obliterated LV lumen -> Decreased CO
Dx: EKG and Echo
Tx: beta blockers, IVF

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4
Q

Initial management of NB of diabetic mother w/shaking, holosystolic murmur, elevated BR

A

Check Blood sugar level
IDMs have high glucose levels
Upon delivery -> maternal glucose gone
Infants continue to make insulin = blood sugar levels drop

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5
Q

MC presentation of CAH

A

Hypotensive child w/severe electrolyte abnormalities

Girls - ambiguous genitalia, inappropriate facial hair, virilization, menstrual abnormalities

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6
Q

Electrolyte changes seen with CAH

A

HypoNatremia
HyperKalemia
HypoChloremia
Hypoglycemia

Decreased Aldosterone and cortisol

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7
Q

How is CAH diagnosed

A

Serum electrolytes

Increased 17-OH progesterone

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8
Q

Infants to mothers with Graves

A

If post thyroidectomy - Grave’s TSI levels increase to 500x normal after thyroidectomy
IgG autoabs cross placenta causing thyrotoxicosis in fetus and neonate

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9
Q

Irritability or lethargy suggest

A

Meningitis

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10
Q

MCC of neonatal sepsis

A

Pneumonia

Meningitis

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11
Q

Signs and Sx’s of neonatal sepsis

A
Poor oral intake
Irritability
Hypo/hyperthermia
Resp distress
Jaundice
Vomiting
Bulging fontanelles
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12
Q

How does infant botulinism present

A

Descending flaccid paralysis

BL bulbar palsy - ptosis, sluggish pupillary response to light, poor suck/gag reflex, drooling, constipation

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13
Q

Cause of infant botulinism - not honey

A

Increased incidence in Cali, Penn, Utah from soil

Botulinim spores from environment/dust = spore ingestion

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14
Q

Neonatal Toxoplasmosis Presentation

A

Chorioretinitis
Hydrocephalus
Multiple ring enhacing lesions - CT

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15
Q

Neonatal Syphilis Presentation

A
Rash on palms and soles
Snuffles
Frontal bossing
Hutchinson teeth
Saddle nose
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16
Q

Neonatal Rubella

A
PDA 
Blueberry muffin rash
Cataracts
Deafness
HSM
Thrombocytopenia
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17
Q

Neonatal CMV

A
Periventricular calcifications 
Chorioretinitis
Microcephaly
Hearing loss - Unilateral
Petechiae
18
Q

Neonatal Herpes

A

Wk 1: shock and DIC
Wk 2: Vesicular skin lesions
Wk 3: Encephalitis

19
Q

Best initial Dx test for Neonatal Toxoplasmosis

A

Elevated IgM to toxo

20
Q

Most accurate Dx test for Neonatal Toxoplasmosis

A

PCR for toxo

21
Q

TX for Neonatal Toxoplasmosis

A

Pyrimethazine and sulfadiazine

22
Q

Best initial test for Neonatal Syphilis

A

VDRL or RPR

23
Q

Most accurate test for Neonatal Syphilis

A

FTA ABS or Dark Field Microscopy

24
Q

Tx for Neonatal Syphilis

A

PCN

25
Q

Test for Neonatal Rubella

A

Maternal IgM w/clinical Dx

26
Q

Tx for Neonatal Rubella

A

Supportive

27
Q

Best initial test for Neonatal CMV

A

Urine or Saliva viral titers

28
Q

Most accurate test for Neonatal CMV

A

Urine or Saliva PCR for viral DNA

29
Q

Tx for Neonatal CMV

A

GAnciclovir w/si’s of end organ damage

30
Q

Best initial test for Neonatal Herpes

A

Tzanck smear

31
Q

Most accurate test for Neonatal Herpes

A

PCR

32
Q

Tx for Neonatal Herpes

A

Acyclovir

Supportive Care

33
Q

Varicella Presentation

A

Multiple highly pruritic vesicular rash - teardrops
Begins on face
Fever and malaise

34
Q

Best initial and most accurate test for Varicella

A

Initial - Tzanck - multinucleated giant cells

Accurate - Viral culture

35
Q

Tx for Varicella

A

Supportive, topical ointment

36
Q

Rubeola or measles Presentation

A
3 C's: 
Cough
Coryza
Conjunctivities 
Koplik spot - gray macule on buccal surface
37
Q

Test for Rubeola or measles

A

most accurate - IgM abs

38
Q

Presentation of Fifth dz/erythema infectiosum

A

Low grade fever/no prodrome
Progresses to rash w/slapped cheek - maculopapular rash starts on arms and spreads to trunk and legs
Rash worsens w fever and sun exposure

39
Q

Presentation of Roseola

A

High Fever >40 C, no other sx’s for 3-4 days
THEN

Progresses to maculopapular diffuse rash as fever breaks
- begins on trunk, quickly spread to face and extremities lasting < 24 hours

40
Q

Mumps presentation

A

Fever precedes parotid swelling and/or orchitis