MTB

Question 1

Describe the structure of Mycobacterium tuberculosis.

Answer 1

Slide 4-5

Question 2

What are the clinical manifestations of TB? What are the possible outcomes of a TB infection?

Answer 2

Slide 6-7

Question 3

How is TB transmitted and how may our immune system protect us from it? How is a granuloma formed and what are the different types? How is this immune response potentially harmful?

Answer 3

Slides 9-16

Question 4

How does Mtb enter phagocytes?

Answer 4

Slide 19

Question 5

What are the ways in which Mtb can avoid being killed by macrophages?

Answer 5

-resistance to antimicrobial stresses/oxygen-dependent killing
-inhibiting phagosome maturation
-inhibiting antigen presentation to T cells
-escaping from the phagosome to the cytoplasm
-inducing macrophage necrosis

Slides 20-33

Question 6

Where does latent TB reside?

Answer 6

Slides 35-38

Question 7

In what physiological state are persistent M. tuberculosis?

Answer 7

Slide 39

Question 8

How does the immune response maintain latency?

Answer 8

Slide 40

Question 9

How is TB treated?

Answer 9

Slide 42

Question 10

What types of AMR are there for TB? How is drug resistance acquired by Mtb vs by people?

Answer 10

Slides 45-47