MT1 > Human Disease Definitions 2 Flashcards

1
Q

What is “descriptive epidemiology”?

A

Collecting data and describing occurrence of human diseases. May imply methods of disease detection.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is “analytical epidemiology”?

A

Analysis of a particular disease using either “case control method” or “cohort method” (longitudinal study). Relies on statistical inferences.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is “experimental epidemiology”?

A

Tests the effectiveness of a new drug/vaccine using appropriate scientific method.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What 3 components make up the epidemiological triad?

A
  1. Agent
  2. Host
  3. Vector
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What are examples of the “agent” component of the triad?

A

Bacteria, Protozoa, Virus, Prions, Chemicals.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What are examples of the “host” component of the triad?

A

Humans, Animals, Plants, Bacteria.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What are examples of the “vector” component of the triad?

A

Ticks, Mosquitoes, Needles, Surgical devices.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are some examples of techniques that can be used to detect an infectious agent?

A

PCR, Microarray, Elisa, Epi-fluorescence microscopy.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

When was the first antibiotic discovered? What was it?

A

Penicillin discovered in 1928, and was in major use by the beginning of WWII.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What differentiates the attitudes of biologists from the attitudes of physicians re: infectious disease?

A

Biologists: consider infectious agents.
Physicians: consider symptoms and affected organs.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What percentage of world deaths are caused by communicable diseases? What about non-communicable diseases? Injury?

A
  • Communicable disease: 32%
  • Non-communicable disease: 58%
  • Injury: 9%
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is the goal of epidemiology?

A

To prevent and control health risks faced by human populations.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What tools exist to control disease at the “Host” level of organization?

A
  • Vaccines and toxoids

- Antibiotics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What tools exist to control disease at the “Environment” level of organization?

A
  • Control vector via insecticide
  • Hygienic procedures
  • Genetic engineering to control disease gene expression
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What did the traditional model of epidemiology stipulate regarding disease transmission?

A

Exposure > Disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What does the new model of molecular epidemiology stipulate regarding disease transmission?

A

Exposure > Internal dose > Effective dose > Altered function > Disease > Prognosis

17
Q

Give some reasons for why valid biomarkers are important in epidemiology.

A
  • Delineates the continuum of events
  • Identifies low-dose exposure
  • Early identification
  • Reduces misclassifications
  • Identifies exposure mechanism
  • Accounts for variability
  • Enhanced assessment
18
Q

What 3 major levels of organization are inherent to molecular epidemiology?

A
  1. Population (behaviour, environment)
  2. Organism (exposure, transmission)
  3. Cell (genetics, substrate, cell-cell communication)
19
Q

T or F: levels of organization are only relevant to the infectious agent, and have no bearing on the host.

A

False. The level of organization of both the vector and the host (population, organism, cell) can impact all aspects of a disease.

20
Q

What 4 major non-biological factors can play a role in human epidemiology?

A
  1. History
  2. Geography
  3. Social characteristics
  4. Status
21
Q

What are the 5 phylogenies of pathogenic bacteria?

A
  1. Spirochetes
  2. Chlamydia
  3. Actinobacteria
  4. Firmicutes
  5. Proteobacteria
22
Q

What is an example of an ssDNA (parvo) virus?

A

Teno torque.

23
Q

What is an example of a hepadna virus?

A

Hepatitus virus.

24
Q

What is an example of a pox virus?

A

Smallpox.

25
Q

What is an example of a herpes virus?

A

Herpes.

26
Q

What is an example of a picorna virus? (ssRNA)

A

Polio.

27
Q

What is an example of an orthomyxo virus? (ssRNA)

A

Influenza.

28
Q

What are the 7 baltimore classifications of viruses?

A
  1. dsDNA (+)
  2. ssDNA
  3. dsRNA (+)
  4. ssRNA virus (+)
  5. ssRNA (-)
  6. ssRNA retrovirus (+)
  7. dsDNA (-)
29
Q

What is an example of a reovirus? (dsRNA)

A

Rota virus.

30
Q

What are examples of enveloped, single-stranded RNA virus?

A

Influenza, measles, mumps.