MSRA Revision Gold Flashcards

1
Q

Which pneumonia is usually preceded by recent influenza infection?

A

Staphylococcus aureus pneumonia

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2
Q

What type of organism is pneumocystis jirovecii?

A

Fungus

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3
Q

Which pneumonia is commoner in people with COPD?

A

Hemophilus influenza pneumonia

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4
Q

In which of the pneumonias can autoimmune hemolytic anemia and erythema multiforme be seen?

A

Mycoplasma pneumoniae

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5
Q

What are the atypical pneumonias?

A

✓ Mycoplasma pneumoniae
✓ Legionella pneumophila

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6
Q

Which pneumonia is usually associated with infected air conditioning units?

A

Legionella pneumophila pneumonia

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7
Q

Which of the pneumonias is usually associated with lymphopenia and hyponatremia?

A

Legionella pneumophila pneumonia

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8
Q

Which of the pneumonias is classically seen in alcoholics?

A

Klebsiella pneumoniae

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9
Q

Which of the pneumonias usually has no chest signs?

A

Pneumocystis jirovecii pneumonia

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10
Q

Describe idiopathic interstitial pneumonia?

A

Non-infective pneumonias

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11
Q

Common example of idiopathic interstitial pneumonia is?

A

Cryptogenic organising pneumonia

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12
Q

What is a possible lung complication of rheumatoid arthritis?

A

Cryptogenic organising pneumonia

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13
Q

What is a possible lung complication of amiodarone therapy?

A

Cryptogenic organising pneumonia

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14
Q

Timeframe of hospital-acquired pneumonia?

A

Developing 48hours or more after admission

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15
Q

Classical X-ray finding in pneumonia?

A

Consolidation

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16
Q

What defines confusion in the CURB-65 assessment?

A

Abbreviated mental test score of <= 8/10

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17
Q

What defines Respiratory abnormality in the CURB-65 assessment?

A

Respiratory rate > 30

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18
Q

Which CURB-65 value is treated at home?

A

0

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19
Q

Is there a difference between severe asthma and life-threatening asthma?

A

Yes

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20
Q

Give one feature of life-threatening asthma?

A

Silent chest

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21
Q

What are the classification of acute asthma exacerbation?

A

✓ Moderate
✓ Severe
✓ Life-threatening

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22
Q

What are the PEFR classes of acute asthma exacerbation?

A

✓ 50-75% best or predicted
✓ 33-50%
✓ <33%

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23
Q

In which acute asthma exacerbation is SPO2 less than 92%?

A

Life-threatening

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24
Q

In which acute asthma exacerbation category is pCO2 normal?

A

Life-threatening

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25
Q

Which vaccinations are given to COPD patients?

A

✓ Influenza vaccine
✓ Pneumococcal vaccine

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26
Q

What are the general management choices for COPD?

A

✓ Smoking cessation
✓ Vaccination protection
✓ Pulmonary rehabilitation
✓ Bronchodilator therapy

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27
Q

What is the first line medical treatment for COPD?

A

Short acting beta2 agonist (SABA) or Short acting muscarinic antagonist (SAMA)

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28
Q

What are the features that suggest steroid responsiveness in COPD?

A

✓ History of atopy or asthma
✓ Raised eosinophil count
✓ Substantial variation in FEV1 (at least 400ml)
✓ Substantial diurnal variation in peak expiratory flow (at least 20%)

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29
Q

Investigation of choice for idiopathic pulmonary fibrosis?

A

High resolution CT scan

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30
Q

Which ICS is used in the classification of steroid dose in asthma?

A

Budesonide

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31
Q

What is MART in asthma therapy?

A

Maintenance and reliever therapy that is combined (ICS + LABA).

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32
Q

What is the acronym for the treatment steps in asthma?

A

SILL

✓ SABA
✓ ICS
✓ LTRA
✓ LABA
✓ MART

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33
Q

What are the features of Churg-Strauss syndrome?

A

✓ Sinusitis
✓ Asthma
✓ Hematuria
✓ Eosinophilia

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34
Q

What features are common to Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) and Granulomatosis with polyangiitis (Wegenger’s granulomatosis)?

A

✓ Vasculitis
✓ Sinusitis
✓ Dyspnoea

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35
Q

Diagnostic modality for COPD?

A

Spirometry

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36
Q

Red-currant jelly sputum in an alcoholic/diabetic is seen in which pneumonia type?

A

Klebsiella pneumoniae

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37
Q

Paraneoplastic syndrome associated with small cell lung carcinoma?

A

Hyponatremia from SIADH

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38
Q

Bupropion is contraindicated in what condition?

A

Epilepsy

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39
Q

What are the nicotine replacement medications?

A

✓ Bupropion
✓ Varenicline

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40
Q

What are the common side effects of nicotine replacement therapy?

A

Nausea, vomiting, headache and flu-like symptoms

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41
Q

How does Varenicline work?

A

Nicotine receptor partial agonist

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42
Q

When should nicotine replacement therapy medication be started?

A

1-2 weeks before target date to stop

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43
Q

How long should Varenicline treatment continue?

A

12 weeks

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44
Q

Which of the nicotine replacement therapy medications has been shown to be more effective?

A

Varenicline

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45
Q

In what situations should Varenicline be used with caution?

A

History of depression or self harm

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46
Q

Are the nicotine replacement medications (Varenicline and bupropion) contraindicated in pregnancy and breastfeeding?

A

Yes

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47
Q

Which of the nicotine replacement medications is relatively contraindicated in patients with eating disorders?

A

Bupropion

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48
Q

What is Bupropion mechanism of action?

A

NDRI (Norepinephrine and dopamine reuptake inhibitor) and nicotinic antagonist

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49
Q

Which of the nicotine replacement medications has some risk of causing seizures?

A

Bupropion

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50
Q

How are pregnant women tested for smoking?

A

CO (Carbon monoxide) detectors

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51
Q

What is the first line intervention for pregnant women to quit smoking?

A

Cognitive behavioural therapy, motivational interviewing or structured self help

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52
Q

Regarding paraneoplastic syndromes, what are the usual lung syndromes?

A

✓ Hyponatremia from SIADH (small cell)
✓ Hypercalcemia from PTH-rp (squamous cell)

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53
Q

What are the key treatment modalities for Granulomatosis with polyangiitis?

A

✓ Steroids
✓ Cyclophosphamide
✓ Plasma exchange

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54
Q

Which of the vasculitides is associated with a saddle-shape nose deformity?

A

Granulomatosis with polyangiitis

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55
Q

What is the usual cause of palpable purpuric rash over the buttocks?

A

Henoch-Schonlein purpura

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56
Q

What are the key question points for silicosis?

A

✓ Foundry worker
✓ Upper zone interstitial lymph nodes
✓ ‘Egg-shell’ calcification of the hilar lymph nodes

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57
Q

What is the normal PaO2 on air?

A

> 10kPa

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58
Q

Which nerve supplies the deltoid muscle?

A

Axillary nerve

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59
Q

Which nerve supplies serrratus anterior?

A

Long thoracic nerve

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60
Q

Damage of which nerve results in winged scapula?

A

Long thoracic nerve

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61
Q

What are the LOAF muscles?

A

✓ Lateral two lumbricals
✓ Opponens pollis
✓ Abductor pollis brevis
✓ Flexor pollis brevis

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62
Q

What nerve supplies the LOAF muscles?

A

Median nerve

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63
Q

What is the function of musculocutaneous nerve?

A

Elbow flexion and supination

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64
Q

What injury commonly damages the axillary nerve?

A

Humeral neck fracture

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65
Q

Which nerve flexes the wrist?

A

Ulnar nerve

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66
Q

Which nerve supplies the thenar muscles?

A

Median nerve

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67
Q

Which nerve extends the forearm, wrist, fingers, and thumb?

A

Radial nerve

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68
Q

Which of the brachial plexus palsies is associated with Horner’s syndrome?

A

Klumpke’s palsy

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69
Q

What is the feared complication of displaced fractures of the femoral neck?

A

Avascular necrosis

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70
Q

What are the usual tests for development dysplasia of the hip?

A

Barlow’s test and Ortolani’s test

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71
Q

What are the possible causes of hip problems in children?

A

✓ DDH
✓ Transient synovitis
✓ Perthes disease
✓ Slipped Upper Femoral Epiphysis (obese boys 10-15)
✓ JIA
✓ Septic arthritis

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72
Q

Which of the childhood hip conditions commonly affects obese boys in their early teenage years?

A

Slipped Upper Femoral Epiphysis

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73
Q

Which of the hip conditions affecting children is a degenerative condition due to avascular necrosis of the femoral head?

A

Perthes disease

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74
Q

What ages are usually affected by Perthes disease?

A

4-8 years

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75
Q

Which hip condition affecting children commonly follows a viral infection?

A

Transient synovitis (irritable hip)

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76
Q

What is the commonest cause of hip pain in children?

A

Transient synovitis

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77
Q

Which nerve adducts the thigh?

A

Obturator nerve

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78
Q

What is the preferred treatment for undisplaced intracapsular hip fracture?

A

Internal fixation or hemiarthroplasty if unfit

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79
Q

Positive Trendelenburg test is usually found in which nerve injury of the leg?

A

Superior gluteal nerve

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80
Q

Which nerve injury causes ‘can’t rise from a seat, can’t climb stairs’?

A

Inferior gluteal nerve

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81
Q

What are the 4 As of ankylosing spondylitis?

A

✓ Anterior uveitis
✓ Apical fibrosis
✓ Aortic regurgitation
✓ Achilles tendonitis

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82
Q

Which medications cause rhabdomyolysis?

A

Statins

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83
Q

What type of crystals is normal in urine?

A

Hyaline cast

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84
Q

What type of cast is seen in chronic kidney disease?

A

Granular casts

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85
Q

Which kind of casts indicate glomerular inflammation?

A

White and red cell casts

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86
Q

Describe the crystals in pseudogout?

A

Weakly-positively birefringent rhomboid shaped crystals

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87
Q

Which age group does pseudogout affect predominantly?

A

Elderly

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88
Q

What are the risk factors for pseudogout in the young? (<60)

A

✓ Acromegaly
✓ Hyperparathyroidism
✓ Wilson’s disease
✓ Hemochromatosis
✓ Low magnesium, low phosphate

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89
Q

What are the most commonly affected joints in pseudogout?

A

✓ Knee
✓ Wrist
✓ Shoulder

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90
Q

X-ray finding of chondrocalcinosis or linear calcifications of the meniscus and articular cartilage of the knee is seen in?

A

Pseudogout

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91
Q

What is the treatment of pseudogout?

A

NSAIDS or steroids as for gout (intra-articular, intramuscular, oral)

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92
Q

Which arthritis affects large weight bearing joints as well as DIP & PIP joints?

A

Osteoarthritis

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93
Q

Does osteoarthritis have a sex predilection?

A

No. Similar incidence in men and women

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94
Q

What are the x-ray findings common to both osteoarthritis and rheumatoid arthritis?

A

Loss of joint space

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95
Q

What are the key question features in Paget’s disease of the bone?

A

✓ Elderly man
✓ Bone pains
✓ Deaf
✓ Raised ALP
✓ Skull x-ray shows thickened vault

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96
Q

Summarily, what happens in Paget’s disease of the bone?

A

Increased and uncontrolled bone turnover

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97
Q

Is Paget’s disease of the bone primarily a disorder of osteoblasts or osteoclasts?

A

Osteoclasts

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98
Q

Which bones are most commonly affected in Paget’s disease of the bone?

A

Skull, spine/pelvis, and long bones of the lower extremities

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99
Q

Which sex has a higher incidence of Paget’s disease of the bone?

A

Males

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100
Q

Which condition presents with morning stiffness involving the muscles?

A

Polymyalgia rheumatica

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101
Q

Two closely related inflammatory disorders to remember?

A

✓ Polymyalgia rheumatica
✓ Temporal arteritis

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102
Q

Which muscle region does polymyalgia rheumatica commonly affect?

A

Proximal limb muscles

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103
Q

The antibody most associated with rheumatoid arthritis?

A

Anti-cyclic citrullinated peptide antibody

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104
Q

Bamboo spine is seen in what condition?

A

Ankylosing spondylitis

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105
Q

Which type of glands does Sjogren’s syndrome affect?

A

Exocrine glands

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106
Q

Sjogren’s syndrome increases the risk for which malignancy?

A

Lymphoid malignancy

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107
Q

What is the classic triad of symptoms in Behcet’s syndrome?

A

✓ Anterior uveitis
✓ Mucosal ulcers
✓ Genital ulcers

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108
Q

Which autoimmune disease is commoner in males?

A

Behcet’s syndrome

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109
Q

What is the biochemical findings in osteomalacia?

A

✓ Low calcium
✓ Low phosphate
✓ High ALP
✓ High PTH

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110
Q

Medications known to cause pulmonary fibrosis include?

A

✓ Methotrexate
✓ Bleomycin

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111
Q

What enzyme does methotrexate inhibit its action?

A

Dihydrofolate reductase

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112
Q

Which enzyme is essential for synthesis of purines and pyrimidines?

A

Dihydrofolate reductase

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113
Q

What are the side effects of methotrexate?

A

✓ Mucositis
✓ Myelosuppression
✓ Pneumonitis
✓ Pulmonary fibrosis
✓ Liver fibrosis

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114
Q

How frequently is methotrexate taken?

A

Weekly

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115
Q

How long after methotrexate use can pregnancy be considered for both sexes?

A

6 months

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116
Q

HLA B27 is associated with which conditions?

A

✓ Ankylosing spondylitis
✓ Anterior uveitis
✓ Reactive arthritis

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117
Q

Which HLA is associated with rheumatoid arthritis?

A

HLA-DR4

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118
Q

Which chromosomes gene code for HLA antigens?

A

Chromosome 6

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119
Q

What type of hypersensitivity is anaphylaxis?

A

Type 1

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120
Q

Important side effect of bisphosphonate?

A

Osteonecrosis of the jaw

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121
Q

What exactly does bisphosphonates do?

A

Inhibits osteoclast activity thereby decreasing demineralisation activities

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122
Q

What is the usual cause of granulomatous thickening of the aortic arch?

A

Takayasu’s arteritis

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123
Q

Which antibody is commonly associated with ulcerative colitis?

A

P-ANCA

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124
Q

List the conditions associated with ANA antibody?

A

✓ Sjogren’s syndrome
✓ SLE
✓ Diffuse cutaneous systemic sclerosis (also anti-scl-70 antibodies)
✓ Limited cutaneous systemic sclerosis (anti-centromere antibodies)

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125
Q

What medications are known to cause reactivation of tuberculosis?

A

✓ Infliximab
✓ Corticosteroids

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126
Q

What is the current guidance on treatment of rheumatoid arthritis?

A

DMARD monotherapy ± short course of bridging prednisolone

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127
Q

What type of hypersensitivity is graft versus host disease?

A

Type IV (delayed hypersensitivity)

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128
Q

What is the treatment of choice in chronic fatigue syndrome?

A

Graded exercise therapy

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129
Q

Which of the bone disorders have the four usual lab parameters (calcium, phosphate, ALP, PTH) normal?

A

✓ Osteoporosis
✓ Osteopetrosis
✓ Osteogenesis imperfecta

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130
Q

Which of the bone disorders have only one abnormal value (elevated ALP)

A

Paget’s disease of the bone

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131
Q

The important conditions associated with HLA-DR4 are?

A

✓ Rheumatoid arthritis
✓ Type 1 DM

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132
Q

How is osteogenesis imperfecta inherited?

A

Autosomal dominant

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133
Q

What is the treatment of choice for Raynaud’s disease?

A

Nifedipine

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134
Q

An important correlation of polyarteritis nodosa?

A

Positive hepatitis B serology

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135
Q

Is azathioprine safe to use in pregnancy?

A

Yes

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136
Q

How is low vitamin D level (leading to decreased bone mineral content/bone softening) called in adult and growing children?

A

✓ Osteomalacia (adults)
✓ Rickets (growing children)

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137
Q

What is the primary issue in osteomalacia?

A

Vitamin D deficiency

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138
Q

What is the primary treatment for osteomalacia?

A

Vitamin D supplementation

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139
Q

What is the commonest ocular manifestation of rheumatoid arthritis?

A

Keratoconjunctivitis sicca

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140
Q

Which eye condition primarily affects the peripheral retina resulting in tunnel vision?

A

Retinitis pigmentosa

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141
Q

Conditions in children causing strawberry tongue?

A

✓ Scarlet fever
✓ Kawasaki disease

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142
Q

One indication for use of aspirin in children?

A

Kawasaki disease

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143
Q

What type of viruses cause croup?

A

Parainfluenza viruses

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144
Q

What causes scarlet fever?

A

Erythrogenic toxins produced by Group A haemolytic streptococci (Streptococcus pyogenes)

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145
Q

What is the treatment for scarlet fever?

A

Oral penicillin V

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146
Q

Is scarlet fever a notifiable disease?

A

Yes

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147
Q

How bad are the complications of scarlet fever?

A

✓ Acute glomerulonephritis
✓ Otitis media
✓ Rheumatic fever
✓ Invasive complications

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148
Q

What endocrine disorder is associated with cystic fibrosis?

A

Diabetes mellitus

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149
Q

Causes of a marfanoid habitus include?

A

✓ Homocystinuria
✓ Marfan syndrome

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150
Q

What causes Homocystinuria?

A

Deficiency of cystathione beta synthase

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151
Q

Cystic fibrosis is associated with short stature?

A

True

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152
Q

Is Down’s syndrome associated with Hirschprung disease?

A

Yes

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153
Q

Which syndrome is associated with a bicuspid aortic valve?

A

Turner’s syndrome

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154
Q

Conditions that cause recurrent chest infections include?

A

✓ Cystic fibrosis
✓ Down syndrome

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155
Q

An omphalomesenteric band is associated with what condition?

A

Meckel’s diverticulum

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156
Q

What is the mode of inheritance of Duchene muscular dystrophy?

A

X-linked recessive

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157
Q

A cause of coronary artery aneurysm to remember is?

A

Kawasaki disease

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158
Q

Another name for hypogonadotrophic hypogonadism is?

A

Kallman syndrome

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159
Q

Why are statins not coprescribed with macrolides (such as clarithromycin)?

A

Increased risk of rhabdomyolysis

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160
Q

Which breast cancer medication is a monoclonal antibody directed against the HER2/neu receptor?

A

Trastuzumab

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161
Q

Common side effects of Trastuzumab are?

A

✓ Flu-like symptoms
✓ Diarrhoea

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162
Q

Why is an echocardiogram usually performed before starting patients on Trastuzumab?

A

Because of its cardiotoxicity

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163
Q

How does Ciprofloxacin affect the QT interval?

A

Lengthens it

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164
Q

Both loop and thiazide diuretics cause hypokalemia?

A

True

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165
Q

The calcium channel blockers Diltiazem and Verapamil cause heart failure true or false?

A

True

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166
Q

Which of the calcium channel blockers have more peripheral vascular effects than cardiac?

A

Dihidropyridines (Nifedipine, Amlodipine)

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167
Q

The calcium channel blockers Diltiazem and Verapamil are negatively inotropic?

A

True

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168
Q

What is the antidote for aspirin poisoning?

A

Bicarbonate

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169
Q

Which medications precipitate digoxin toxicity?

A

Loop diuretics

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170
Q

What are the two types of heparin?

A

✓ Unfractionated heparin
✓ Low molecular weight heparin

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171
Q

Does protamine sulfate reverse the effect of LMWH?

A

Partially

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172
Q

Which medication is known to reduce seizure threshold?

A

Ciprofloxacin

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173
Q

Which antituberculous drug can cause gout?

A

Pyrazinamide

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174
Q

List three medications that can cause gout?

A

✓ Loop diuretics
✓ Thiazide diuretics
✓ Pyrazinamide

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175
Q

Medications to avoid in the setting of a recent myocardial infarction include?

A

✓ Metformin
✓ Sildenafil

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176
Q

Which overdose has IV bicarbonate as antidote?

A

✓ Tricyclic antidepressants
✓ Salicylate

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177
Q

What is the risk with the use of Flumazenil (the antidote for benzodiazepines)?

A

Risk of seizures

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178
Q

What poison is hydroxycobalamine its antidote?

A

Cyanide

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179
Q

What is the antidote for lead poisoning?

A

Dimercaprol, calcium edetate

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180
Q

What medication causes yellow-green vision?

A

Digoxin

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181
Q

What medications can cause gynecomastia?

A

✓ Digoxin
✓ Spironolactone

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182
Q

The poisoning agent that causes hyperpyrexia is?

A

Carbon monoxide

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183
Q

Four drugs that precipitate digoxin toxicity include?

A

✓ Amiodarone
✓ Spironolactone
✓ Verapamil
✓ Diltiazem

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184
Q

List medications that can cause tremor?

A

✓ Lithium
✓ Ciclosporin
✓ Sodium valproate

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185
Q

Which medication is known to cause non-arteritic anterior ischaemic neuropathy?

A

Sildenafil

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186
Q

Indications for the use of phosphodiesterase type 5 inhibitors?

A

✓ Erectile dysfunction
✓ Pulmonary hypertension

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187
Q

What cancer does tamoxifen predispose to?

A

Endometrial cancer

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188
Q

How does alcohol intake affect P450?

A

✓ Acute intake (inhibitor)
✓ Chronic intake (inducer)

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189
Q

What ABG result is typical of aspirin poisoning?

A

Mixed metabolic acidosis and respiratory alkalosis

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190
Q

What is the effect of heparin on potassium levels?

A

Hyperkalemia

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191
Q

Two medications that can cause depression include?

A

✓ Corticosteroids
✓ Isotretinoin

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192
Q

List the medications that can cause pulmonary fibrosis?

A

✓ Methotrexate
✓ Amiodarone
✓ Nitrofurantoin
✓ Sulfasalazine

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193
Q

What is the treatment of choice for generalized anxiety disorder?

A

Sertraline

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194
Q

Examples of serotonin-noradrenaline reuptake inhibitors include?

A

✓ Duloxetine
✓ Venlafaxine

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195
Q

How is the half-life of lithium?

A

Long, being primarily excreted by the kidney

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196
Q

How does lithium affect the thyroid?

A

Hypothyroidism with thyroid enlargement

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197
Q

How does lithium affect the parathyroid gland?

A

Hyperparathyroidism and resultant hypercalcemia

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198
Q

Which medications increases the risk of ischaemic stroke?

A

✓ COCPs
✓ Antipsychotics

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199
Q

How does anastrozole affect the bone?

A

Osteoporosis

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200
Q

When is tamoxifen indicated in breast cancer?

A

Pre- and peri-menopausal women if ER positive

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201
Q

Which of the female reproductive cancers have incidence increased by early menarche?

A

✓ Breast cancer
✓ Ovarian cancer
✓ Endometrial cancer

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202
Q

What is the treatment of choice for chronic anal fissure?

A

Topical glyceryl trinitrate

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203
Q

Why are small bowel stomas spouted?

A

So that their irritant contents are not in contact with the skin

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204
Q

Which of the breast cancer medications is used in post-menopausal women if ER positive?

A

Anastrozole

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205
Q

An example of an aromatase inhibitor?

A

Anastrozole

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206
Q

Which cancers do COCPs predispose to?

A

✓ Breast cancer
✓ Cervical cancer

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207
Q

What hormone does nexplanon release?

A

Etonogestrel (a progestogen)

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208
Q

What is the most effective form of contraception?

A

Nexplanon. A form of implantable contraceptive

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209
Q

What is the failure rate of nexplanon?

A

0.07/100 women-years

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210
Q

Which of the contraceptive pills takes only 2 days to become effective?

A

Progestogen only pill

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211
Q

Which of the contraceptive pills has no pill free days?

A

Progestogen only pill

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212
Q

What is the mode of action of the progestogen only pill (except desogestrel)?

A

✓ Thickens cervical mucus

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213
Q

Which of the contraceptives inhibit ovulation and thickens cervical mucus?

A

✓ Implantable contraceptive (etonogestrel)
✓ Injectable contraceptive (depo povera)
✓ Desogestrel only pill

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214
Q

What is the primary mechanism of action of intrauterine system (levonorgestrel)

A

Prevents endometrial proliferation

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215
Q

What is the mechanism of action of COCP?

A

Inhibits ovulation

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216
Q

Hormone replacement therapy increases the risk of which cancer?

A

Breast cancer

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217
Q

Unopposed estrogen action predisposes to which cancer?

A

Endometrial cancer

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218
Q

Which female reproductive cancer has smoking and COCP as protective factors?

A

Endometrial cancer

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219
Q

Mutations to the BRCA2 gene predisposes to which cancer?

A

✓ Breast cancer
✓ Ovarian cancer

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220
Q

How does COCP help in reducing ovarian cancer risk?

A

By reducing the number of ovulations

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221
Q

What is the mechanism of action of oxybutynin?

A

Antimuscarinic

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222
Q

Which of the female reproductive cancers is high parity a risk factor for?

A

Cervical cancer

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223
Q

Which female reproductive cancer does PCOS predispose to?

A

Endometrial cancer

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224
Q

What causes tender erythematous lesions on the shins?

A

Erythema nodosum

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225
Q

What are the four major causes of erythema nodosum?

A

✓ Infections (TB)
✓ Systemic disease (Sarcoidosis, IBD, Behcet’s)
✓ Malignancy
✓ Drugs

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226
Q

Which of the tender leg lesions is associated SLE?

A

Pyoderma gangrenosum

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227
Q

Which antibodies are usually used to look for SLE?

A

ANA

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228
Q

Is pyoderma gangrenosum associated with rheumatoid arthritis?

A

Yes

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229
Q

Does the lesion of erythema nodosum heal with scarring?

A

No

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230
Q

What is the key physical characteristic of basal cell carcinoma?

A

Rolled edges

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231
Q

What is the size cut-off point for differentiating nodule from papule

A

5mm

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232
Q

Lupus pernio is seen in what condition?

A

Sarcoidosis

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233
Q

What is the character monicker for basal cell carcinoma?

A

Rodent ulcer

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234
Q

With regards to growth and metastasis, what is the characteristic of basal cell carcinoma?

A

Slow growth and rarely metastatic

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235
Q

What is the most common type of cancer in the western world?

A

Basal cell carcinoma

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236
Q

What type of referral is made for suspected BCC?

A

Routine referral

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237
Q

What topical cream options are there for BCC treatment?

A

✓ Imiquimod
✓ Fluorouracil

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238
Q

Does psoriatic nail changes reflect severity of the disease?

A

No

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239
Q

What is the first line treatment for hyperhidrosis?

A

Topical aluminium chloride

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240
Q

Which medications are options for treatment of hyperhidrosis in secondary care?

A

✓ Topical glycopyrrolate
✓ Botulinum toxin injections

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241
Q

What class of medications is glycopyrrolate?

A

Antimuscarinic

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242
Q

What parts of the body are most affected by vitiligo?

A

Peripheries

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243
Q

What is the phenomenon of new vitiligo lesions secondary to trauma called?

A

Koebner phenomenon

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244
Q

Which of the alopecia types is associated with vitiligo?

A

Alopecia areata

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245
Q

How useful is topical corticosteroids in vitiligo?

A

May reverse changes if applied early

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246
Q

What is the phototherapy of choice in the secondary care of Psoriasis?

A

Narrowband ultraviolet B light

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247
Q

What is the commonest body site for keloid scars?

A

Sternum

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248
Q

What category of disease is erythema multiforme?

A

Hypersensitivity reaction

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249
Q

What is the common trigger for erythema multiforme?

A

Infections

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249
Q

What is the common trigger for erythema multiforme?

A

Infections

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250
Q

Which condition has target lesions as a feature?

A

Erythema multiforme

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251
Q

What is erythema multiforme major?

A

Erythema multiforme with mucosal involvement

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252
Q

Which type of hair loss is caused by severe stress?

A

Telogen effluvium

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253
Q

What is a possible cause for telogen effluvium?

A

Pregnancy

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254
Q

Which type of hair loss causes well-circumscribed areas of total hair loss?

A

Alopecia areata

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255
Q

What defines scarring or non-scarring alopecia?

A

Destruction or preservation of the hair follicle

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256
Q

Common causes of erythema nodosum in females include?

A

✓ Pregnancy
✓ COCP use

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257
Q

Purple painful lesions on the shin should elicit possible diagnosis of?

A

Erythema nodosum

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258
Q

What are the usual inflammatory associations of Ulcerative colitis?

A

✓ large joint arthritis
✓ sacroilitis
✓ Pyoderma gangrenosum

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259
Q

What is pathergy?

A

Hyper reactivity of the skin in response to trauma

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260
Q

What condition commonly exhibits pathergy?

A

Pyoderma gangrenosum

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261
Q

What condition can cause both erythema nodosum and erythema gangrenosum?

A

Inflammatory bowel disease

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262
Q

What are the risk factors for capillary hemangiomas?

A

✓ Female infants
✓ Premature infants
✓ Infants of mother that had chorionic villus sampling

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263
Q

A brown nodule with a fissured greasy surface, well demarcated against the skin, and exhibiting the stuck-on appearance is classical of?

A

Seborrheic keratosis

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264
Q

What cancers can actinic keratoses predispose to?

A

Squamous cell carcinoma

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265
Q

What is the usual first symptom of rosacea?

A

Flushing of the skin

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266
Q

In what condition is rhinophyma seen?

A

Rosacea

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267
Q

What is the indication for dermatology referral in rosacea?

A

Presence of rhinophyma

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268
Q

What is the treatment for mild rosacea?

A

Topical metronidazole

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269
Q

What is the treatment for severe rosacea?

A

Oxytetracycline (systemic)

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270
Q

Does HIV predispose to seborrheic dermatitis?

A

Yes

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271
Q

Which fungus is typically taught to be the cause of seborrheic dermatitis?

A

Malassezia furfur

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272
Q

What conditions are usually associated with seborrheic dermatitis?

A

✓ HIV
✓ Parkinson’s disease

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273
Q

Which seborrheic dermatitis subtype does not have topical ketoconazole as the first line treatment?

A

Scalp seborrheic dermatitis (use preparations containing zinc pyrithione and tar)

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274
Q

Which skin condition is usually associated with coeliac disease?

A

Dermatitis herpetiformis

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275
Q

Are dermatitis herpetiformis lesions commoner in flexor or extensor surfaces?

A

Extensor surfaces

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276
Q

Are keloid scars commoner in flexor or extensor surfaces?

A

Extensor surfaces

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277
Q

What is the pathophysiologic cause of dermatitis herpetiformis?

A

Deposition of IgA in the dermis

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278
Q

Which ulcer types are amenable to compression bandaging?

A

Venous ulcers

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279
Q

What is a normal ABPI index reading?

A

0.9 - 1.2

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280
Q

What ABPI value reflects arterial disease?

A

< 0.9
(Also > 1.2 in arterial calcification such as in diabetics) false negative

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281
Q

What organism causes molluscum contagiosum?

A

Pox virus

282
Q

Is molluscum contagiosum infectious?

A

Yes

283
Q

Should molluscum contagiosum infection preclude school attendance?

A

No

284
Q

How long does it take for molluscum contagiosum lesions to clear?

A

18 months

285
Q

What is a predisposing condition for molluscum contagiosum infection?

A

Atopic eczema

286
Q

What are the indications for specialist referral in the setting of molluscum contagiosum?

A

✓ Eyelid margin/ocular lesions (ophthalmologist)
✓ HIV positive with extensive lesions (HIV specialist)
✓ Adult with anogenital lesions (GUM clinic)

287
Q

What is a known indication for brimonidine?

A

Predominant flushing symptoms in rosacea

288
Q

What is the indication for dermatology referral in acne rosacea?

A

Rhinophyma

289
Q

Does dietary modification help in acne?

A

No

290
Q

Can milia affect adults?

A

Yes, though commoner in newborns

291
Q

What are the management options for BCC?

A

✓ Surgery
✓ Curettage
✓ Cryotherapy
✓ Radiotherapy
✓ Topical cream

292
Q

What is the timeframe for resolution of erythema nodosum lesions?

A

6 weeks

293
Q

What are the infective causes of erythema nodosum?

A

✓ Tuberculosis
✓ Streptococci
✓ Brucellosis

294
Q

What are the drug causes of erythema nodosum?

A

✓ Sulphonamides
✓ Penicillin
✓ COCPs

295
Q

Can pregnancy cause erythema nodosum?

A

Yes

296
Q

Can corticosteroids cause skin depigmentation?

A

Yes, especially in dark skins

297
Q

How does corticosteroids affect hair growth?

A

Excessive hair growth at the site of application

298
Q

What differentiates mycosis fungoides from eczema/Psoriasis?

A

Lesions feature more different colours

299
Q

What are the skin lesions with flexural predilection?

A

✓ Lichen planus
✓ Eczema

300
Q

Which skin lesions are usually described as being polygonal in shape, with a ‘white-lines’ pattern on the surface (Wickham’s striae)?

A

Lichen planus

301
Q

What are the nail features in lichen planus?

A

✓ longitudinal ridging
✓ Thinning of the nail plate

302
Q

Can Lichen planus produce oral lesions?

A

Yes, in 50% of cases

303
Q

A cause of koebner phenomenon?

A

Lichen planus

304
Q

What are the drug causes for lichenoid drug eruptions?

A

✓ Quinin
✓ Gold
✓ Thiazides

305
Q

What is the treatment of choice for lichen planus?

A

Potent topical steroids

306
Q

What is the recommended mouth spray for oral lichen planus?

A

Benzydamine mouthwash

307
Q

What is the first line antiviral medication in shingles?

A

Famciclovir or Valacyclovir

308
Q

What is the most commonly affected dermatome in shingles?

A

T1 to L2

309
Q

What is the first line analgesics in shingles?

A

PCM or NSAIDs

310
Q

What causes pemphigus vulgaris?

A

Antibodies targeted at Desmolein 3

311
Q

Which condition exhibits Nikolsky’s sign?

A

Pemphigus vulgaris

312
Q

What is the first line treatment for pemphigus vulgaris?

A

Steroids

313
Q

What skin condition is particularly seen in Ashkenazi Jews?

A

Pemphigus vulgaris

314
Q

What are the skin conditions commonly associated with mucosal ulceration?

A

✓ Pemphigus vulgaris
✓ Erythema multiforme major

315
Q

What are the drug causes for erythema multiforme major?

A

CAPONS
✓ Carbamazepine
✓ Allopurinol
✓ Penicillin
✓ Oral contraceptive pill
✓ Nevirapine/NSAIDs
✓ Sulphonamides

316
Q

What is the first line therapy for plaque Psoriasis?

A

A potent corticosteroid + vitamin D analogue

317
Q

What therapy is particularly useful in Psoriasis with joint involvement?

A

Methotrexate

318
Q

What differentiates vitamin D analogues from corticosteroids in treating Psoriasis?

A

They can be used long-term as side effects are uncommon

319
Q

Are dermatitis herpetiformis lesions usually flexural or extensor?

A

Extensor

320
Q

What is the pathophysiologic cause for dermatitis herpetiformis

A

Deposition of IgA in the dermis

321
Q

What is the management for dermatitis herpetiformis?

A

✓ Gluten free diet
✓ Dapsone

322
Q

What is the oral medication of choice in treating acne in pregnancy?

A

Erythromycin

323
Q

What are the three classes of topicals used in management of acne?

A

✓ Topical antibiotics
✓ Topical retinoids
✓ Benzoyl peroxide

324
Q

What is the step up management for acne?

A

✓ Single topical therapy
✓ Combined topical therapy
✓ Oral antibiotics
✓ Oral isotretinoin

325
Q

Can topical retinoid be used in pregnancy?

A

No. All retinoids (topical and oral) are contraindicated in pregnancy

326
Q

What is the first line treatment for urticaria?

A

Non-sedating antihistamines

327
Q

What skin condition is commonly seen in patients with Parkinson’s disease?

A

Seborrheic dermatitis

328
Q

What is the most common cause of erythema multiforme?

A

Herpes simplex virus

329
Q

What mineral deficiency causes red, crusted lesions (acrodermatitis)?

A

Zinc

330
Q

Which mineral deficiency causes acrodermatitis?

A

Zinc

331
Q

Which of the B vitamin deficiency causes angular cheilosis?

A

Vitamin B2 (riboflavin)

332
Q

List five causes of scarring alopecia?

A

✓ Trauma
✓ Burns
✓ Lichen planus
✓ Discoid lupus
✓ Radiotherapy
✓ Tinea capitis

333
Q

Fine medications that can cause alopecia?

A

✓ Cytotoxics
✓ OCPs
✓ Heparin
✓ Carbamazepine
✓ Colchicine

334
Q

Which mineral deficiencies can cause alopecia?

A

✓ Zinc
✓ Iron

335
Q

What dermatologic presentation in children warrants an immediate work-up to identify diagnosis?

A

Purpura

336
Q

Purpura in children should raise suspicion of which conditions?

A

✓ ALL
✓ Meningococcal disease

337
Q

What is the usual pathophysiologic cause of purpura?

A

Low platelets

338
Q

Can cough cause petechiae?

A

Yes, by raising superior vena cava pressure

339
Q

Differentiate the settings for Cushing’s and Curling’s ulcers?

A

✓ Cushing’s (severe head trauma)
✓ Curling’s (severe burns)

340
Q

List three common skin disorders associated with pregnancy?

A

✓ Atopic eruption of pregnancy
✓ Polymorphic eruption of pregnancy
✓ Pemphigoid gestationis

341
Q

Does vitiligo exhibit koebner phenomenon?

A

Yes

342
Q

Which peripheral vasodilator has been shown to improve healing rate in venous ulcers?

A

Pentoxifylline oral

343
Q

Which SLE skin manifestation typically has a lace-like appearance and brought on by cold?

A

Livedo reticularis

344
Q

Which of the erythema is typically caused by heat exposure?

A

Erythema ab igne

345
Q

Which eczema associated conditions in children is a medical emergency?

A

Eczema herpeticum

346
Q

How is Eczema herpeticum treated?

A

IV antivirals (IV aciclovir)

347
Q

What is the difference between hypertrichosis and hirsutism?

A

✓ Hirsutism (androgen-dependent hair growth in women)
✓ Hypertrichosis (androgen-independent hair growth)

348
Q

Which of the eating disorders causes hypertrichosis?

A

Anorexia nervosa

349
Q

Which of the facial dermatologic condition has no place for steroid use?

A

Acne rosacea

350
Q

Is ongoing infection a common cause of non-healing leg ulcer?

A

No

351
Q

What body sites are dermatitis herpetiformis lesions commonly seen?

A

✓ Knees
✓ Elbows
✓ Buttocks

352
Q

What causes guttate Psoriasis?

A

Streptococcal upper respiratory tract infection

353
Q

Which of the vascular birthmark do not spontaneously resolve?

A

Port wine stains

354
Q

What type of hypersensitivity is allergic contact dermatitis?

A

Type IV

355
Q

In what setting is allergic contact dermatitis usually typified?

A

On the head following hair dyes

356
Q

What is the common precipitant of guttate Psoriasis?

A

Streptococcal infection

357
Q

What is the the treatment for pityriasis rosae?

A

Self-limiting, resolves after around 6 weeks

358
Q

Which cancer diagnosis should be considered in a patient with acanthosis nigricans?

A

Gastric cancer

359
Q

What age is the peak incidence of vitiligo?

A

20-30 years

360
Q

Which parts of the body are mostly affected in vitiligo?

A

The peripheries

361
Q

What makes the treatment of scalp Psoriasis different from chronic plaque Psoriasis?

A

Treatment is with potent topical steroids (Topical betamethasone valerate)

362
Q

What is the place of emollients in management of Psoriasis?

A

Reduce scale and pruritus only

363
Q

What is the first line treatment for chronic plaque Psoriasis?

A

Potent corticosteroid + vitamin D analogue

364
Q

What is the pathophysiologic cause of bullous pemphigoid?

A

Antibodies against hemidesmosomal proteins BP180 and BP230

365
Q

What is the mainstay of treatment for lichen planus

A

Potent topical steroids

366
Q

Which dermatologic condition has the classical dimple sign?

A

Dermatofibroma

367
Q

What is the first line treatment for acne?

A

Topical retinoid or Benzoyl peroxide

368
Q

A rapidly growing hand lesion in pregnancy is likely to be a?

A

Pyogenic granuloma

369
Q

A mass with pearly, rolled edges suggest?

A

Basal cell carcinoma

370
Q

Which basal cell carcinoma locations warrant an urgent referral?

A

Lesions around eyelid and nasal ala

371
Q

What conditions make up sore throat?

A

✓ Pharyngitis
✓ Tonsillitis
✓ Laryngitis

372
Q

What is the centor criteria value to warrant antibiotic use?

A

3 or more

373
Q

What is the antibiotic of choice for sore throat?

A

Phenoxymethylpenicillin or Clarithromycin (if Penicillin allergy)

374
Q

For how long should a sore throat requiring antibiotics be treated?

A

7 or 10 days

375
Q

List three key question findings for otosclerosis?

A

✓ Family history
✓ Tinnitus
✓ Conductive hearing loss

376
Q

What type of hearing loss does stickler syndrome cause?

A

Sensorineural hearing loss

377
Q

What is the mode of inheritance for otosclerosis?

A

Autosomal dominant

378
Q

What is the management for otosclerosis?

A

Hearing aid and Stapedectomy

379
Q

Is geographic tongue benign?

A

Yes

380
Q

Which sex has more glue ear?

A

Males

381
Q

What is the commonest cause of conductive hearing loss in childhood?

A

Glue ear

382
Q

How long is the wait period for a perforated eardrum to seal before ENT referral?

A

6-8 weeks

383
Q

Which part of the ear does meniere’s disease affect?

A

Inner ear

384
Q

Does meniere’s disease have a sex predilection?

A

No

385
Q

What is the mnemonic for symptoms of meniere’s disease?

A

Voice Note HAT
✓ Vertigo
✓ Nystagmus
✓ Hearing loss
✓ Aural fullness
✓ Tinnitus

386
Q

One ear condition to inform DVLA?

A

Meniere’s disease

387
Q

What is the DVLA advice for meniere’s disease?

A

Cease driving until symptoms satisfactorily controlled

388
Q

What is the treatment for acute attacks of meniere’s disease?

A

Buccal or intramuscular prochlorperazine

389
Q

What is the medication for prevention of attacks of meniere’s disease?

A

Betahistine

390
Q

Cervical rib is commoner in which sex?

A

Females

391
Q

What is the treatment of choice for acute Tonsillitis?

A

Phenoxymethylpenicillin

392
Q

What is a feared complication of acute tonsillitis?

A

Peritonsillar abscess

393
Q

Does corticosteroid have a place in the management of tonsillitis?

A

Yes, can reduce severity and duration of pain

394
Q

Does nasal polyp have a sex predilection?

A

Yes, commoner in males

395
Q

List two syndromes associated with nasal polyps?

A

✓ Churg-Strauss syndrome
✓ Kartagener’s syndrome

396
Q

What metabolic disorder is associated with nasal polyp?

A

Cystic fibrosis

397
Q

What medication is known to cause nasal polyps?

A

Aspirin

398
Q

What type of hearing loss does Otitis media cause?

A

Conductive hearing loss

399
Q

Which ear condition is known to worsen during pregnancy?

A

Otosclerosis

400
Q

Which cause of sensorineural hearing loss is usually age related?

A

Presbycusis

401
Q

What is the pathophysiologic cause of otosclerosis?

A

Fixation of the stapes at the oval window

402
Q

Can otosclerosis cause tinnitus?

A

Yes

403
Q

What is the cut of day/duration for clinical decision making in suspected acute sinusitis?

A

10 days

404
Q

What is the antibiotic of choice for acute sinusitis?

A

Phenoxymethylpenicillin

405
Q

Which manoeuvre is for diagnosis of BPPV?

A

Dix-Hallpike manoeuvre

406
Q

Vestibular rehabilitation (Brandt-Daroff exercises) is useful in which ear condition?

A

BPPV

407
Q

What is the first line treatment for otitis externa?

A

Topical antibiotic or a combined topical antibiotic and steroid

408
Q

Ear pain with a history of recent swimming suggests?

A

Otitis externa

409
Q

Which dermatologic condition is usually associated with Otitis externa?

A

Seborrheic dermatitis

410
Q

A cause of high-frequency hearing loss?

A

Presbycusis

411
Q

Is presbycusis same as noise-related hearing loss?

A

No

412
Q

What are the two classes of epistaxis?

A

✓ Anterior bleeds
✓ Posterior bleeds

413
Q

How do you manage meniere’s disease in the GP?

A

Refer for ENT assessment to confirm diagnosis

414
Q

What is the management of secondary post-tonsillectomy small bleed?

A

Admit for ENT review and antibiotic therapy

415
Q

How important is post-tonsillectomy hemorrhage?

A

Immediate ENT review

416
Q

How best can malignant Otitis externa be called/described?

A

Osteomyelitis of the temporal bone

417
Q

What investigation is indicated in malignant Otitis externa?

A

CT scan of the temporal bone

418
Q

How is malignant Otitis externa treated?

A

IV antibiotics (prolonged course)

419
Q

What is the indication for referral in Otitis externa?

A

Failure of topical antibiotic therapy

420
Q

Is tinnitus same as ringing in the ear?

A

Yes

421
Q

Acoustic neuroma is associated with which type of neurofibromatosis?

A

Type 2

422
Q

What are the LANAQ drugs?!

A

Drugs that cause tinnitus
✓ Loop diuretics
✓ Aspirin
✓ NSAIDs
✓ Aminoglycosides
✓ Quinine

423
Q

Can impacted ear wax cause tinnitus?

A

Yes

424
Q

List medications that can cause gingival hyperplasia?

A

✓ Ciclosporin
✓ Phenytoin
✓ Calcium channel blockers

425
Q

What is one drug cause of Hirsutism?

A

Phenytoin

426
Q

Which of the hematological cancer usually causes gingival hyperplasia?

A

AML

427
Q

What is the peak year of incidence for glue ear?

A

2 years

428
Q

Which cranial nerves are affected by acoustic neuroma?

A

V, VII and VIII

429
Q

Which medication is used by ENT surgeons in all cases of sudden onset sensorineural hearing loss?

A

High dose oral corticosteroids

430
Q

Medical condition spread by contact with urine of rats and cattle?

A

Weil’s disease (leptospirosis)

431
Q

What organism causes Weil’s disease?

A

Leptospira interrogans

432
Q

In what condition is antimitochondrial antibodies seen?

A

Primary biliary cirrhosis

433
Q

What is the first line treatment for migraine in children aged 12-17?

A

PCM/NSAID

434
Q

Which medications usually used in migraine are avoided in adolescents?

A

✓ Metoclopramide
✓ Aspirin

435
Q

ABO incompatibility is what type of hypersensitivity?

A

Type II

436
Q

Rheumatoid arthritis is what type of hypersensitivity reaction?

A

Type III

437
Q

Chronic asthma is what type of hypersensitivity reaction?

A

Type IV

438
Q

Define delayed puberty in a male?

A

Testicular volume <4 ml after 14 years of age

439
Q

What are the signs of puberty in a male?

A

✓ Reddening of scrotal skin
✓ Growth of the testes
✓ Growth spurt

440
Q

What timeframe can Prednisolone improve chances of recovery in Bell’s palsy?

A

Within 72 hours

441
Q

What are the four indications for ENT referral in the setting of Bell’s palsy?

A

✓ Bilateral Bell’s palsy
✓ Recurrent Bell’s palsy
✓ Unclear diagnosis
✓ No improvement within 1 month

442
Q

In what condition affecting the major blood vessels should ACE inhibitors be avoided?

A

Aortic stenosis

443
Q

Global ST and PR segment changes is seen in?

A

Pericarditis

444
Q

Which of the thyroid hormone disorders is associated with pericarditis?

A

Hypothyroidism

445
Q

What is the most specific ECG marker for pericarditis?

A

PR depression

446
Q

Which investigation should all patients with suspected acute pericarditis have?

A

Transthoracic echocardiogram

447
Q

What is the first line treatment for acute pericarditis?

A

Combination of NSAID and colchicine

448
Q

Medication to be avoided in patients taking a selective serotonin reuptake inhibitors?

A

Triptans

449
Q

Why should triptans be avoided in patients taking SSRI?

A

Increased risk of serotonin syndrome

450
Q

Which antidepressants is safest in the setting of recent myocardial infarction?

A

Sertraline

451
Q

Which antidepressant is used for children when indicated?

A

Fluoxetine

452
Q

The most common side effects of SSRIs are of which body systems?

A

Gastrointestinal

453
Q

What medication increases the risk of gastrointestinal bleeding when using SSRIs?

A

NSAIDs

454
Q

Which of the SSRIs causes QT prolongation?

A

Citalopram and Escitalopram

455
Q

Which of the antidepressants is preferred for patients on warfarin/heparin?

A

Mirtazapine

456
Q

Which of the antidepressants poses the least risk in abrupt discontinuation?

A

Fluoxetine

457
Q

Which of the antidepressants has a high incidence of discontinuation symptoms?

A

Paroxetine

458
Q

What is the feared complication of using SSRIs in first trimester?

A

Risk of congenital heart defects

459
Q

Which of the SSRIs has an increased risk of congenital malformations?

A

Paroxetine

460
Q

What is the possible complication from using SSRIs in third trimester?

A

Persistent pulmonary hypertension of the newborn

461
Q

Which antiplatelet is preferred for TIA and Ischaemic stroke?

A

Clopidogrel

462
Q

What are the three antiplatelet medications that can be used for anticoagulation after Ischaemic stroke or TIA?

A

✓ Clopidogrel
✓ Aspirin
✓ Dipyridamole

463
Q

What is the indication for carotid endarterectomy?

A

Stenosis greater than 70% or 50% (depending on criteria used)

464
Q

How long after delivery should their be need for contraception?

A

After 21 days

465
Q

Which emergency contraceptives can be used postpartum in a breastfeeding/non-breastfeeding woman?

A

Progesterone only EC (Levonelle and ellaOne)

466
Q

What are the important timeframes for intrauterine device/system insertion postpartum?

A

Insert within first 48 hours or wait until after 4 weeks

467
Q

How effective is lactational amenorrhea?

A

98% effective, provided use is perfect
✓ Exclusive (no supplement)
✓ Amenorrheic
✓ <6 months postpartum

468
Q

How can COCP affect breastfeeding mothers?

A

It can reduce breast milk production

469
Q

In the management of COPD, what is the next step after exhausting the usefulness of SABA/SAMA?

A

Assess for features suggesting steroid responsiveness

470
Q

Is routine spirometric reversibility testing necessary in the diagnosis/assessment for therapy in COPD?

A

No

471
Q

What are the inhaler options in the management of COPD after considering steroid responsiveness?

A

✓ LABA + LAMA (unresponsive)
✓ LABA + ICS (responsive)

472
Q

In what circumstances should theophylline dose be reduced in the management of COPD?

A

Patient on macrolide or fluoroquinolone

473
Q

What antibiotic is used commonly for prophylaxis in COPD patients?

A

Azithromycin

474
Q

What are the precautions before starting COPD patients on Azithromycin antibiotic prophylaxis therapy?

A

✓ CT scan (exclude bronchiectasis)
✓ Sputum culture (exclude atypical infections/tuberculosis)

475
Q

Peripheral edema, raised JVP, systolic parasternal heave, and loud P2 in a COPD patient suggests which complication?

A

Cor pulmonale

476
Q

Which surgery is a part of treatment modalities for select COPD patients?

A

Lung volume reduction surgery

477
Q

An example of an atypical antidepressant?

A

Mirtazapine

478
Q

What is the mechanism of action of mirtazapine?

A

Blockage of alpha2-adrenergic receptors

479
Q

Which antidepressant has beneficial effects on elderly patients?

A

Mirtazapine
✓ Appetite stimulant
✓ Sedation at small doses

480
Q

The antidepressant with paradoxical dose effects on sleep?

A

Mirtazapine

481
Q

What time of the day is mirtazapine preferably taken?

A

Evening (sedating)

482
Q

What percentage of undescended testes is bilateral?

A

25%

483
Q

Four complications of undescended testes?

A

✓ testicular cancer
✓ infertility
✓ torsion
✓ psychological

484
Q

How does unilateral undescended testes differ from the bilateral form regarding urgency of referral?

A

✓ Unilateral (refer at 3 months, not later than 6 months)
✓ Bilateral (refer within 24 hours of birth, possible endocrine/genetic anomaly)

485
Q

In rhabdomyolysis, what elements are released/increased?

A

✓ Creatinine kinase
✓ Phosphate
✓ Myoglobin

486
Q

Why is calcium low in rhabdomyolysis?

A

Myoglobin binds calcium

487
Q

What class of drug is Venlafaxine?

A

SNRI

488
Q

What medications are preferred for panic disorders?

A

SSRIs (Paroxetine)

489
Q

Which sex has a higher prevalence for panic disorder?

A

Females

490
Q

In DKA, how should insulin be administered?

A

✓ Correction insulin infusion (fixed rate)
✓ Regular long lasting insulin (continued as usual)
✓ **stop short acting insulin

491
Q

Why is insulin infusion given at a fixed rate in DKA?

A

Because emphasis is on correction of ketone levels and not glucose levels

492
Q

Acute DKA is caused by uncontrolled lysis of which food class?

A

Lipid (lipolysis)

493
Q

What is the dose of insulin in acute DKA?

A

0.1unit/kg/hour

494
Q

What rate of potassium correction requires cardiac monitoring?

A

> 20 mmol/hour

495
Q

What are the criteria to say DKA is resolved?

A

✓ Blood ketone < 0.6 mmol/l
✓ pH > 7.3
✓ Bicarbonate > 15 mmol/l

496
Q

What is the indication for endocrinologist review in the setting of DKA?

A

Ketonemia and acidosis not yet resolved within 24 hours

497
Q

What is a feared complication of DKA management in children/young adults?

A

Cerebral edema (from fluid correction)

498
Q

On what days of bronchiolitis infection does the infection get worse before improving?

A

Day 3-5

499
Q

What is a red flag sign to necessitate immediate hospital referral in bronchiolitis?

A

Grunting respiration

500
Q

What virus causes bronchiolitis?

A

Respiratory syncytial virus

501
Q

Are antibiotics used in the treatment of bronchiolitis?

A

No, it’s a viral infection

502
Q

At what age is the peak incidence of bronchiolitis?

A

3-6 months

503
Q

What is the most commonly injured ligament in inversion injuries of the ankle?

A

Anterior talofibular ligament

504
Q

Which of the ankle ligaments functions to strengthen the medial longitudinal arch?

A

Calcaneonavicular ligament

505
Q

Which is the weakest lateral ligament of the ankle?

A

Anterior talofibular ligament

506
Q

Which ankle ligament is likely to be injured by direct blow or heavy object drop on the foot?

A

Lisfranc ligament

507
Q

What is the antidote for dabigatran toxicity?

A

Idarucizumab

508
Q

For how long should patients with provoked pulmonary embolism be treated/anticoagulated?

A

3 months

509
Q

What defines provoked pulmonary embolism?

A

PE provoked by a temporary risk factor such as following a surgery

510
Q

What is the first line treatment for PE?

A

DOACs (Apixaban and Rivaroxaban)

511
Q

What is the choice of anticoagulant for suspected PE?

A

DOACs

512
Q

What is the choice anticoagulant in the setting of PE and DOACs are unsuitable for use?

A

✓ LMWH followed by dabigatran/edoxaban or
✓ LMWH followed by a vitamin K antagonist (warfarin)

513
Q

What is the minimum length of anticoagulation?

A

3 months

514
Q

What is the choice of treatment for PE in the setting of hemodynamic instability?

A

Thrombolysis

515
Q

What is the treatment option to consider for patients with repeat pulmonary embolisms?

A

IVC filter

516
Q

What medication should be coprescribed for patients on strong opioids?

A

Laxative

517
Q

What is the preferred opioid in mild to moderate renal impairment?

A

Oxycodone

518
Q

What is the preferred opioid in severe renal impairment?

A

✓ Alfentanil
✓ Buprenorphine
✓ Fentanyl

519
Q

List four agents that can be used in the treatment of metastatic bone pain?

A

✓ Opioids
✓ Bisphosphonates
✓ Radiotherapy
✓ Denosumab

520
Q

Which of the opioid side effects tend to be transient?

A

✓ Nausea
✓ Drowsiness

521
Q

Which of the opioid side effects tend to be persistent?

A

Constipation

522
Q

Which childhood condition comes with a barking cough?

A

Croup

523
Q

Which medication is a must for patients with croup?

A

Oral dexamethasone (Single dose of 0.15 mg/kg)

524
Q

Which viruses are implicated the most in croup?

A

Parainfluenza viruses

525
Q

In what condition is subglottic narrowing (‘steeple sign’) seen?

A

Croup

526
Q

In what condition is ‘thumb sign’ seen?

A

Acute epiglottitis

527
Q

What is the emergency treatment for croup?

A

✓ High flow oxygen
✓ Nebulised adrenaline

528
Q

What is a key differentiating factor between adult BLS and pediatric BLS?

A

5 rescue breaths

529
Q

On which artery is circulation assessed in infants?

A

Brachial/Femoral pulse

530
Q

What are the usual exam features for primary hyperparathyroidism?

A

✓ Elderly woman with unquenchable thirst
✓ Inappropriately normal or raised parathyroid hormone level

531
Q

What is the most common cause of primary hyperparathyroidism?

A

Solitary adenoma

532
Q

What is the characteristic x-ray finding of hyperparathyroidism?

A

Pepperpot skull

533
Q

What are the investigation findings in primary hyperparathyroidism?

A

✓ Raised calcium
✓ Low phosphate
✓ Raised or normal parathyroid hormone

534
Q

What is the determining factor for treatment following a fragility fracture?

A

Age
>= 75 (start Bisphosphonates, without need for a Dexa scan)
<= 75 (do DEXA scan and assess risk for further fractures using FRAX assessment)

535
Q

How does a raised INR relate to liver enzyme: inhibition/induction?

A

Inhibition

536
Q

What is the mnemonic for liver enzyme inducers?

A

GRASS BC

✓ Griseofulvin
✓ Rifampicin
✓ Antiepileptics (Phenytoin, Carbamazepine)
✓ Smoking
✓ St. John’s wort
✓ Barbiturates (phenobarbitone)
✓ Chronic alcohol intake

537
Q

Does pregnancy preclude the use of beta2 agonists or inhaled corticosteroids for asthma?

A

No

538
Q

Which of the eye conditions do flashes and floaters signify?

A

Vitreous/retinal detachment

539
Q

Define transient monocular visual loss?

A

Sudden, transient loss of vision that lasts less than 24 hours

540
Q

How is amaurosis fugax treated?

A

As TIA
Aspirin 300mg

541
Q

What causes Ischaemic optic neuropathy?

A

Occlusion of the short posterior ciliary arteries

542
Q

What are the usual causes of central retinal vein occlusion?

A

✓ Glaucoma
✓ Polycythemia
✓ Hypertension

543
Q

Cherry red spot on a pale retina is a feature of?

A

Central retinal artery occlusion

544
Q

What is the usual question features for idiopathic intracranial hypertension?

A

Young obese female with headaches, and finding of papilloedema with normal neurological findings

545
Q

What is another name for idiopathic intracranial hypertension?

A

Pseudomotor cerebri

546
Q

What medications are associated with pseudomotor cerebri?

A

✓ Lithium
✓ COCPs
✓ Tetracycline
✓ Vitamin A
✓ Steroids

547
Q

Which nerve palsy may be seen in idiopathic intracranial hypertension?

A

6th nerve palsy

548
Q

Which of the medications used in the management of idiopathic intracranial hypertension can be used to bring about weight loss too?

A

Topiramate

549
Q

What is the management of idiopathic intracranial hypertension?

A

✓ Weight loss
✓ Diuretics
✓ Topiramate
✓ Surgery (optic nerve decompression)

550
Q

The dermatologic condition caused by over exposure to infrared radiation is?

A

Erythema ab igne

551
Q

What type of cancer does erythema ab igne predispose to?

A

Squamous cell cancer

552
Q

What is the recommended salt intake in the UK?

A

Less than 6g/day

553
Q

At what age should a blood pressure of greater than or equal to 135/85 warrant treatment?

A

<80 plus risk factors

554
Q

In which orthopaedic condition causing back pain do patients find it easier to walk uphill rather than downhill?

A

Spinal stenosis

555
Q

What is the treatment for lumbar spinal stenosis?

A

Laminectomy

556
Q

What happens pathologically in Perthes disease?

A

Avascular necrosis of the femoral head

557
Q

At what age is avascular necrosis commoner?

A

4-8 years of age

558
Q

What is the physical characteristics for children with slipped upper femoral epiphysis?

A

Overweight or tall thin adolescents

559
Q

What is the management of Perthes disease in patients less than 6 years?

A

Observation

560
Q

Which of the emergency contraception can be used up to 5 days after the earliest ovulation date or within 120 hours following intercourse?

A

Copper IUD

561
Q

What is the mechanism of action for levonorgestrel?

A

✓ Stop ovulation
✓ Prevent implantation

562
Q

What dose of levonorgestrel should be used for patients with BMI >26 or weight over 70kg?

A

Double dose

563
Q

How effective is levonorgestrel as emergency contraception?

A

84% if used within 72 hours

564
Q

Can levonorgestrel be used more than once in a menstrual cycle?

A

Yes

565
Q

How soon can hormonal contraception be started after using levonorgestrel for emergency contraception?

A

Immediately

566
Q

What is the mechanism of action of ulipristal (EllaOne)?

A

Selective progesterone receptor modulator

567
Q

How does ulipristal work?

A

Inhibition of ovulation

568
Q

Is concomitant use of levonorgestrel with ulipristal recommended?

A

No

569
Q

How soon after ulipristal use should hormonal contraception be used?

A

At least after 5 days

570
Q

Can ulipristal be used more than once in a cycle?

A

Yes

571
Q

How does emergency contraception use affect breastfeeding?

A

✓ Ulipristal (delay for one week before breastfeeding)
✓ Levonorgestrel (no affectation)

572
Q

What is the most effective emergency contraception?

A

Copper IUD

573
Q

How effective is copper IUD as emergency contraception?

A

99% effective

574
Q

Is antibiotic coverage necessary when using copper IUD?

A

If the patient is considered to be at high risk of STI

575
Q

Which shoulder pathology is characterized by a painful arc of abduction on examination between 90 and 120 degrees?

A

Subacromial impingement

576
Q

What is another name for subacromial impingement?

A

Painful arc syndrome

577
Q

What is the common cause of most styes?

A

Staphylococcus bacteria

578
Q

A firm painless lump in the eyelid most likely represents?

A

A meibomian cyst (chalazion)

579
Q

Another name for a chalazion is?

A

Meibomian cyst

580
Q

What is the management of styes?

A

Hot compress and analgesia

581
Q

In what cases will stye management require topical antibiotic use?

A

Associated conjunctivitis

582
Q

What is the management of a chalazion?

A

Many resolve spontaneously, some require surgical drainage

583
Q

What is the advice regarding breastfeeding in HIV positive patients in the UK?

A

Do not breastfeed

584
Q

What is the recommendation regarding mode of delivery in HIV positive women?

A

✓ Vaginal delivery if viral load < 50 copies/ml at 36 weeks
✓ Otherwise, CS

585
Q

What is the special precaution in managing HIV positive women during CS in the UK?

A

Zidovudine infusion should be started 4 hours before beginning of the CS

586
Q

What is the recommendation regarding therapy for newborns of HIV positive mothers?

A

✓ Oral zidovudine (if viral load <50 copies/ml)
✓ Otherwise triple ART

587
Q

How long is treatment for HIV exposed neonates?

A

4-6 weeks

588
Q

Which STI produces strawberry cervix (erythematous cervix with punctate lesions)?

A

Trichomonas vaginalis

589
Q

What are the key features of Trichomonas vaginalis infection?

A

✓ Offensive green/yellow discharge
✓ Strawberry cervix

590
Q

Most useful diagnostic modality for ankylosing spondylitis?

A

Plain x-ray of sacroiliac joints

591
Q

What investigation should be requested if ankylosing spondylitis is suspected and x-ray is not suggestive?

A

MRI

592
Q

In what instances are the usual medications used for rheumatoid arthritis useful in managing ankylosing spondylitis?

A

Peripheral joint involvement

593
Q

In what situations should a suspected TIA warrant imaging?

A

Patient on warfarin, a DOAC, or has a bleeding disorder

594
Q

How long do TIA symptoms take to resolve?

A

Typically 1 hour

595
Q

What are the contraindications to the use of the traditional treatment modality (antithrombotic therapy, aspirin 300) in the setting of a TIA?

A

✓ Patient has a bleeding disorder
✓ Patient already on low-dose aspirin (continue until reviewed by specialist)

596
Q

What is the recommended antithrombotic therapy for patients who have a TIA or a stroke?

A

✓ Clopidogrel (first line)
✓ Aspirin + Dipyridamole (patients who cannot tolerate Clopidogrel)

597
Q

Which worm usually presents with itchy bottom worse at night?

A

Threadworm

598
Q

What is the treatment for pinworm?

A

Mebendazole for patient and all household members (single dose)

599
Q

At what age should a diagnosis of new iron-deficiency anaemia warrant urgent colorectal cancer pathway referral?

A

Age >= 60

600
Q

What is the best timing for starting anticoagulation following a TIA or stroke?

A

✓ TIA (immediately once hemorrhage is excluded)
✓ Stroke (2 weeks later)

601
Q

Is azathioprine used for management of acute flare of ulcerative colitis?

A

No, for maintenance treatment

602
Q

Which of the IBD is treated with methotrexate?

A

Ulcerative colitis

603
Q

Which condition has the M rule?

A

Primary biliary cholangitis
✓ IgM
✓ anti-mitochondrial antibodies
✓ Middle aged females

604
Q

Test of cure cervical smear is performed when?

A

6 months after treatment

605
Q

What is Russell’s sign?

A

Scars over the metacarpophalangeal joints due to the fingers scraping the front teeth during induced vomiting in patients with bulimia nervosa

606
Q

What is the management of bulimia nervosa?

A

Referral for specialist care

607
Q

What are the conditions that make expectant management of miscarriage inappropriate?

A

✓ Increased risk of bleeding
✓ Previous adverse experiences associated with pregnancy
✓ increased risk of the side effects of hemorrhage
✓ Evidence of infection

608
Q

Which antibiotic is usually prescribed for COPD patients for prophylaxis?

A

Azithromycin

609
Q

What is the reversal agent for dabigatran?

A

Idarucizumab

610
Q

What are the criteria for performing alteplase thrombolysis following acute ischemic stroke?

A

✓ Ability to be administered within 4.5 hours of onset of stroke symptoms
✓ Hemorrhage has been definitely excluded

611
Q

Which medication used in the treatment of rheumatoid arthritis show hypersensitivity similar to that with aspirin?

A

Sulfasalazine

612
Q

Three medications with cross-sensitivity include?

A

✓ Aspirin
✓ Sulfasalazine
✓ Sulphonamides

613
Q

What are the two key medications in management of angina?

A

✓ Beta blockers
✓ Nifedipine

614
Q

What causes hyperacute kidney rejection?

A

Preexisting antibodies (such as ABO antibodies)

615
Q

What is the most common type of organ transplant rejection?

A

Acute T-cell medicated rejection

616
Q

What is the treatment for acute antibody-mediated rejection?

A

3-5 plasma exchange sessions daily

617
Q

What is the treatment for Acute T-cell mediated rejection?

A

IV methylprednisolone

618
Q

What chromosome codes HLA?

A

Chromosome 6

619
Q

What type of hypersensitivity reaction is hyperacute graft rejection?

A

Type II hypersensitivity

620
Q

Which of the graft rejection type has no remedial treatment?

A

Hyperacute rejection

621
Q

How soon does hyperacute graft rejection occur?

A

Minutes to hours

622
Q

What is the management for secondary dysmenorrhoea?

A

Refer to gynecology

623
Q

What causes Ramsay Hunt syndrome?

A

Reactivation of the Varicella zoster virus in the geniculate ganglion of the seventh cranial nerve

624
Q

What is the treatment for Ramsay Hunt syndrome?

A

Oral aciclovir and corticosteroids

625
Q

Should asymptomatic bacteriuria in catheterised patients be treated?

A

No

626
Q

What is the Nitrofurantoin dosing for UTI in pregnant women and men?

A

100 mg bd for 7 days

627
Q

What are the indications for urine culture after suspected UTI in non-pregnant women?

A

✓ Age > 65 years
✓ Visible or non-visible haematuria

628
Q

What is the difference in the management options for asymptomatic bacteriuria in pregnant women and catheterised patients?

A

Treat the former, but not the later

629
Q

Give the indications for IV adenosine and IV amiodarone respectively?

A

✓ IV Adenosine (supraventricular tachycardia, ie regular narrow complex tachycardia)
✓ IV Amiodarone (Ventricular tachycardia, regular broad complex tachycardia) without adverse features

630
Q

When is synchronized cardioversion indicated?

A

Ventricular tachycardia with adverse features

631
Q

What are the adverse features in peri-arrest rhythms?

A

✓ Shock
✓ Syncope
✓ Myocardial ischaemia
✓ Heart failure

632
Q

Maximum number of shocks in DC cardioversion for peri-arrest rhythms with adverse features?

A

3 (after that seek expert help)

633
Q

What is the first line treatment for regular narrow complex tachycardia?

A

Vagal manoeuvre (before IV Adenosine)

634
Q

What is the first line treatment for chronic heart failure?

A

ACE-inhibitor and beta-blocker

635
Q

What is the second line treatment (add-on) drug in chronic heart failure?

A

Aldosterone antagonist (Spironolactone)

636
Q

Which test must be done prior to commencing Azathioprine treatment?

A

Check thiopurine methyltransferase deficiency (TPMT)

637
Q

What is the function of thiopurine methyltransferase?

A

Metabolizes thiopurine medications such as azathioprine and mercaptopurine

638
Q

Is azathioprine safe in pregnancy?

A

Yes

639
Q

What should you do to the dose of azathioprine if it has to be used with allopurinol?

A

Reduce it’s dose

640
Q

Which medications can exacerbate plaque Psoriasis?

A

✓ Beta blockers
✓ Antimalarials
✓ Lithium
✓ NSAIDs

641
Q

Which infection can trigger guttate psoriasis?

A

Streptococcal infection

642
Q

Factors that can cause psoriasis exacerbation?

A

✓ Trauma
✓ Alcohol
✓ medications
✓ withdrawal of systemic steroids

643
Q

Is hand preference in an infant (before 12 months) normal?

A

No. Could be an indicator of cerebral palsy

644
Q

At what point should unsmiling children be referred?

A

10 weeks

645
Q

What is the maximum time a child can be allowed to sit supported?

A

12 months

646
Q

At what age is a child expected to start sharing toys?

A

3 years

647
Q

What medications are used in ER+ve breast cancer?

A

✓ Tamoxifen
✓ Anastrozole

648
Q

What is the patient characteristics for tamoxifen and anastrozole therapy in ER+ve breast cancer?

A

✓ Pre or peri-menopausal (Tamoxifen)
✓ Postmenopausal (Anastrozole)

649
Q

How does radiotherapy help in the management of patients with breast cancer?

A

May reduce the risk of recurrence by around two-thirds

650
Q

What is a contraindication for Trastuzumab?

A

Patients with a history of heart disorders

651
Q

Which breast cancer patients benefit from Trastuzumab?

A

HER2 positive cancers

652
Q

How many sample confirmation of azoospermia is necessary before patient is safe to have intercourse without protection?

A

653
Q

Which is a more effective method of sterilisation, male or female?

A

Male

654
Q

What is the failure rate of male sterilisation?

A

1 per 2,000

655
Q

What is the success rate of vasectomy reversal?

A

✓ 55% within 10 years
✓ 25% after 10 years

656
Q

Which two tests must adult patients with suspected asthma have?

A

✓ FeNO test
✓ Spirometry with a bronchodilator reversibility test

657
Q

What features differentiates scarlet fever from Kawasaki disease?

A

✓ Lip is spared of rash
✓ No conjunctivitis
✓ Evidence of URTI such as purulent tonsils

658
Q

In what condition is phenoxymethylpenicillin indicated?

A

Scarlet fever

659
Q

What is a feared complication of Kawasaki disease?

A

Coronary artery aneurysm

660
Q

How is Kawasaki disease diagnosed?

A

Clinically

661
Q

What is the treatment of Kawasaki disease?

A

✓ Aspirin
✓ Intravenous immunoglobulin

662
Q

How does hyperthyroidism affect the bones?

A

Increases osteoclast activity leading to osteoporosis

663
Q

Which mechanism explains most complications seen in thyroid disorders?

A

Metabolism

664
Q

After what time should thyroid hormone levels be checked after dose adjustments?

A

After 8-12 weeks

665
Q

What is the therapeutic goal in managing thyroid hormone levels?

A

Normalisation of TSH levels

666
Q

Which medications can interact with levothyroxine if given within 4 hours?

A

Iron, calcium carbonate

667
Q

Apart from antibiotics, risk factors for C. difficile infection include?

A

Proton pump inhibitors

668
Q

What differentiates C. difficile infection from exposure?

A

✓ C difficile infection (C difficile toxin)
✓ C difficile exposure (antigen)

669
Q

What is the drug of choice for C difficile infection?

A

Vancomycin

670
Q

What is the second line therapy for C difficile infection or recurrent episode (within 12 weeks)?

A

Fidaxomicin

671
Q

What is the treatment for local anaesthetic toxicity?

A

IV 20% lipid emulsion

672
Q

What is the advantage of combining adrenaline to some local anaesthetic agents?

A

It allows use of increased doses of the local anaesthetic agent

673
Q

What is the colour coding for the inhalers?

A

✓ Blue inhaler (SABA)
✓ Brown inhaler (ICS)

674
Q

How much dose reduction is ok with inhaled steroids at a time as per asthma management?

A

25-50 %

675
Q

What is the hematological management of acute limb ischemia?

A

IV heparin

676
Q

How long after treatment for pneumonia should a patient have repeat chest X-ray?

A

6 weeks after clinical resolution

677
Q

What is the first line medication for community acquired pneumonia?

A

Amoxicillin

678
Q

A 2 year old boy with a three day history of vomiting and profuse watery diarrhoea is most likely a diagnosis of?

A

Rotavirus infection

679
Q

40 year old overweight alcoholic woman presenting with upper abdominal pain worse after eating and radiating through to her back is suggestive of?

A

Pancreatitis

680
Q

Another name for herpes simplex keratitis?

A

Dendritic ulcer

681
Q

Features of dendritic ulcer (herpes simplex keratitis)?

A

✓ Watery eyes
✓ Pain
✓ Redness
✓ Blurring of vision

682
Q

Which medication should be used for nasal blockage secondary to allergy between Xylometazoline and Beclomethasone?

A

Beclomethasone (steroid)

683
Q

What class of drug is Xylometazoline?

A

Decongestant/antihistamine

684
Q

Which of the alopecia types is common following chemotherapy?

A

Anagen effluvium

685
Q

What are the vaccine recommendations for patients with heart failure?

A

✓ Annual influenza vaccine
✓ One-off Pneumococcal vaccine

686
Q

What is a strong indication for use of digoxin in heart failure?

A

Coexisting atrial fibrillation

687
Q

What saturation indicates oxygen prescription?

A

Saturation < 94%

688
Q

What necessitates careful consideration with respect to using nitrate in ACS?

A

Hypotension

689
Q

What is the QRS duration cut off for narrow complex tachycardia and broad complex tachycardia?

A

120ms

690
Q

What is the treatment of choice for Torsades de Pointes?

A

Magnesium sulfate

691
Q

Describe the ECG features in Torsades de Pointes?

A

✓ Polymorphic ventricular tachycardia
✓ prolonged QTc interval

692
Q

In the setting of PE, in what condition is V/Q scan preferred to CTPA?

A

If there is renal impairment

693
Q

In the management of hypertension what determines addition of Spironolactone or beta-blocker?

A

Potassium levels

694
Q

Which patients should receive one shock followed by two minutes of CPR?

A

Unwitnessed patients in VF/pulseless VT

695
Q

Which of the peri-arrest rhythms requires IV adrenaline?

A

✓ Pulseless electrical activity
✓ Asystole

696
Q

What are the adverse features in arrhythmias that change management?

A

✓ Syncope
✓ Myocardial ischaemia
✓ Heart failure
✓ Shock

697
Q

Another name for defibrillation?

A

Unsynchronized cardioversion

698
Q

What is the preferred diagnostic modality for suspected aortic dissection?

A

CT angiography chest/abdomen/pelvis

699
Q

Describe the usefulness of the different investigations for suspected aortic dissection?

A

✓ CT angiography (1st choice if stable)
✓ Transoesophageal echocardiogram (1st choice if unstable)

700
Q

What are the two types of classification schemes for aortic dissection?

A

✓ Stanford
✓ DeBakey

701
Q

What are the management options for the different types of aortic dissection?

A

✓ Type A (surgical management)
✓ Type B (conservative)

702
Q

What distinguishes type A aortic dissection from type B aortic dissection?

A

Type A (ascending aorta)
Type B (descending aorta)