MSRA: Lymphoma

Question 1

What is the Ann Arbor staging system?

Answer 1

Stage 1 lymphoma in a single node region
Stage 2 two separate regions on one side of the diaphragm
Stage 3 spread to both sides of hand diaphragm
Stage 4 diffuse of disseminated involvement of one or more extra-lymphatic organs such as bone marrow or lungs

A - absence of B symptoms
B - B symptoms present

Question 2

What is the most common type of high grade non-Hodgkin’s lymphoma?

Answer 2

Diffuse large B cell lymphoma

Question 3

What is the most common type of low grade non-Hodgkin’s lymphoma?

Answer 3

Follicular lymphoma

Question 4

What are the symptoms of Non-Hodgkin’s lymphoma?

Answer 4

Painless lymphadenopathy
Hepatosplenomegaly
B symptoms
Bone marrow involvement -> cytopenia

Question 5

What is the genetic abnormality in Burkitt’s lymphoma?

Answer 5

Transformation t(8:14)

Question 6

What are Reed-Sternberg cells?

Answer 6

Multinucleated giant cells derived from B lymphocytes found in Hodgkin’s lymphoma

Question 7

What are the risk factors for Hodgkin’s lymphoma?

Answer 7

EBV
Increasing age

Question 8

What is the presentation of Hodgkin’s lymphoma?

Answer 8

Painless lymphadenopathy - typically cervical/supraclavicular
B symptoms
Alcohol-induced pain

Question 9

What are the B symptoms in lymphoma?
and what is their significance?

Answer 9

Associated with a poor prognosis.

Night sweats
Fever
Weight loss