MSRA: Chronic Myeloid Leukaemia Flashcards

1
Q

Which cells proliferate in CML?

A

Granulocytes (eosinophils, basophils, neutrophils)

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2
Q

What is the genetic abnormality in CML?

A

9:22 translocation forming Philadelphia chromosome

Created BCR-ABL proto-oncogene with tyrosine kinase activity

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3
Q

What are the symptoms of CML?

A
Anaemia
Splenomegaly, abdominal fullness
Weight loss
Night sweats 
Fatigue
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4
Q

What are the blood results in CML?

A

Anaemia
15-30% have raised platelets
Elevated WCC - predominantly neutrophils and basophils

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