MSRA: Chronic Myeloid Leukaemia Flashcards
1
Q
Which cells proliferate in CML?
A
Granulocytes (eosinophils, basophils, neutrophils)
2
Q
What is the genetic abnormality in CML?
A
9:22 translocation forming Philadelphia chromosome
Created BCR-ABL proto-oncogene with tyrosine kinase activity
3
Q
What are the symptoms of CML?
A
Anaemia Splenomegaly, abdominal fullness Weight loss Night sweats Fatigue
4
Q
What are the blood results in CML?
A
Anaemia
15-30% have raised platelets
Elevated WCC - predominantly neutrophils and basophils