MSRA: Epilepsy

Question 1

What are the side effects of phenytoin?

Answer 1

Peripheral neuropathy
Hyperplasia gums
Enzyme inducer
Neuro: ataxia
Y Duyptren’s contracture
Tired from macrocytic anaemia
OO double vision
Increased vitamin D metabolism
Nodes: lymphadenopathy

Question 2

What are the adverse effects of Carbamazepine?

Answer 2

Agranulocytosis
P450 Inducer
SIADH

Question 3

What are the adverse effects of sodium valproate?

Answer 3

Vomiting
Alopecia
Low cell count
Pancreatitis
Retention of fat (weight gain)
Oedema
Ataxia
Teratogenic, tremor
Enzyme inhibitor

Question 4

What are the adverse effects of lamotrigine?

Answer 4

Steven-Johnson syndrome

Question 5

What drugs are used in the management of generalised tonic-clonic seizures?

Answer 5

Men first line: Sodium Valproate
Women first line: Lamotrigine or Keppra

Question 6

What drugs are used in the management of absence seizures?

Answer 6

First line:Ethosuximide
Second line: Sodium valproate

Question 7

What drugs are used in the management of focal seizures?

Answer 7

First line: Keppra or Lamotrigine

Question 8

What are the driving rules following first, unprovoked seizure?

Answer 8

No driving for 6 months

Question 9

What are the key features of bengin rolandic epilepsy?

Answer 9

Occur at night
Children
Facial twitching or numbness, drooling, unable to speak