MSKs Clinical Lecture 8_ Pediatric Bone Tumors

Question 1

What 5 locations account for 80% of all metastatic bone lesions?

Answer 1

Lung, Breast, Prostate, Renal, and Thyroid

Question 2

Review the attached picture

Answer 2

Question 3

What two neoplasams target the Epiphisis?

Answer 3

Question 4

What 5 neoplasmas targert the metaphisis?

Answer 4

Question 5

What 4 neoplasmas target the diaphesis?

Answer 5

Question 6

What are the 5 kinds of Periosteal Reactions?

Answer 6

Mutli-Lamellated is often refered to as onion skin and is typical of Ewing Sarcoma

Question 7

What demographic is most at risk for bone neoplasms?

Answer 7

White kids (boys) under the age of 14

Question 8

is the most common primary malignant
bone tumor in children and adolescents

Answer 8

Osteosarcoma

Question 9

Under age 10, which is more common osteosarcoma or ewings sarcoma?

Answer 9

Ewings sarcoma

Question 10

What is the classic clinical manifestation of Osteosarcoma?

Answer 10

the “sunburst” pattern on a plain film xray

Question 11

What is the peak age range for ewings sarcoma?

Answer 11

10-20 years of age

Question 12

Ewings sarcoma arises from which embryonic cell?

Answer 12

Neural crest cells

Question 13

What mutation gives rise to ewings sarcoma?

Answer 13

t(11:22)

Question 14

What is the xray presentation of Osteoid osteoma

Answer 14

dense sclerosis
surrounds small radiolucent
nidus,

Question 15

What is Diskitis

Answer 15

It is an infection of the intervertebral disk space. It typically occures in children under 5. It is seen on an MRI is a narrowing of the disk space. It is often caused by Staph a (can be caused by tuburculosis). It results in a loss to lumbar lordosis