MSK/Rheum (Exam 3) Flashcards
What condition involves bone overgrowth/bone abnormality during bone development that changes function of hip joint?
FAI (Femoroacetabular Impingement)
What condition AND specific subtype has acetabular involvement; extra bone extends over normal rim of acetabulum?
FAI (Femoroacetabular Impingement)
- Pincer
What condition AND specific subtype has femoral head involvement; femoral head not round so does not run smoothly inside acetabulum
FAI (Femoroacetabular Impingement)
- Cam
What condition involves pain aggravated with turning, twisting, prolonged standing/squatting?
FAI (Femoroacetabular Impingement)
What is the best physical exam test for evaluating FAI (Femoroacetabular Impingement)? What other test may be considered?
FADIR is best test
- Also FABER
What condition involves dull or sharp groin pain that may radiate; catching, clicking that may cause pain?
Labral Tear of hip
What is the best radiology test for a Labral Tear of hip?
MR Arthrogram is best test
What LE condition is most common in dancers?
Snapping Hip Syndrome
What LE condition involves tendon sliding over bone at top of femur (involves IT band and greater trochanter)?
EXternal Snapping Hip Syndrome
What LE condition involves tendon sliding over bone structures anteriorly (involves iliopsoas tendon over femoral head)
INternal Snapping Hip Syndrome
What LE condition involves snapping/popping sensation worse with activity (painless or painful); pseudosubluxation?
Snapping Hip Syndrome
With Snapping Hip Syndrome, what is often possible on physical exam?
Snapping often reproducible by patient
What PE exam is used to test internal Snapping Hip Syndrome? What PE exam is used to test external Snapping Hip Syndrome?
- Internal: FABER
- External: passive internal and external rotation of hip
What condition involves PAIN, lateral hip pain with localized pain to greater trochanter?
Greater Trochanter Pain Syndrome
What is the most common cause of lateral hip pain in adults?
Greater Trochanter Pain Syndrome
What LE condition can present with positive Trendelenburg Test on physical exam?
Greater Trochanter Pain Syndrome
With what LE condition are steroid injections VERY effective?
Greater Trochanter Pain Syndrome
What is the Unhappy Triad? What is another name for this?
Unhappy Triad = Triad of O’Donoghue
- MCL, ACL and medial meniscus
What LE condition has an MOI that most commonly involves knee flexion + foot planted AND lateral impact causing valgus stress?
Medial Collateral Ligament (MCL) Sprain
What is the least common knee ligament injury?
Lateral Collateral Ligament (LCL) Sprain
What type of physical exam is performed for an MCL or LCL sprain?
Varus (medial force applied) or valgus (lateral force applied)
What is the most common knee ligament injury?
Anterior Cruciate Ligament (ACL) Injury
What injury are 50% of Anterior Cruciate Ligament (ACL) Injury associated with?
50% associated with meniscus injury
Which type of knee ligament injury requires contact on MOI? Which one classically does not require contact?
- Medial Collateral Ligament (MCL) Sprain: contact required
- Anterior Cruciate Ligament (ACL) Injury: NON-contact
What LE condition involves feeling/hearing “pop” → immediate pain and swelling with feeling of instability?
Anterior Cruciate Ligament (ACL) Injury
What three physical exam tests are performed for an Anterior Cruciate Ligament (ACL) Injury?
Lachman test
- Also Anterior Drawer, and Pivot Shift
Most LE injuries involve supportive care as treatment. Which injury is an exception that often requires surgery?
Anterior Cruciate Ligament (ACL) Injury
What MOI is most common with a Posterior Cruciate Ligament (PCL) Injury?
Most likely MVA trauma injury
What type of knee ligament injury is least likely to be injured in athletics?
Posterior Cruciate Ligament (PCL) Injury
Which meniscus is more susceptible to injury?
Medial
What LE condition involves joint line pain; “locking” or “catching” of knee?
Medial Meniscus Injury
What physical exam test is performed to test for a Medial Meniscus Injury? Describe this.
McMurray Test
- Medial: hand on medial meniscus and other on foot, ext. rotate foot and apply valgus stress at knee
What physical exam test is performed to test for a Lateral Meniscus Injury? Describe this.
McMurray Test
- Lateral: hand on lateral meniscus and other on foot, int. rotate foot and apply varus stress at knee
What are the three grades of knee sprains? Describe each, AND the recommended treatment for each.
- Grade I (mild stretch): supportive (RICE, weight-bearing as tolerated)
- Grade II (partial tear): supportive +/- surgery (RICE, brace immobilization, PT, possible surgery)
- Grade III (complete tear): surgery (then supportive with crutches, brace, PT)
What LE conditions involves deep knee pain anteriorly?
Patellofemoral Pain Syndrome (Runner’s Knee)
What is the most common knee complaint in primary care medicine?
Patellofemoral Pain Syndrome (Runner’s Knee)
What LE condition involves positive theater sign/long car ride sign; often see crepitus, popping, feeling of instability?
Patellofemoral Pain Syndrome (Runner’s Knee)
What two physical exam tests are performed to test for Patellofemoral Pain Syndrome (Runner’s Knee)?
Patellar Glide
- Also Apprehension Test
What LE condition involves accumulation of fluid in popliteal fossa behind knee?
Baker’s Cyst (Popliteal Cyst)
What LE condition is often asymptomatic, or found incidentally; potential pain with prolonged standing or activity?
Baker’s Cyst (Popliteal Cyst)
What LE condition often occurs after skeletal maturity in adulthood?
Patellar Tendonitis (Jumper’s Knee)
What population is Patellar Tendonitis (Jumper’s Knee) most common in?
Athletes
What treatment is not recommended for Patellar Tendonitis (Jumper’s Knee)?
Steroid injection NOT recommended
What LE condition involves : progressive localized pain to lateral thigh?
Iliotibial Band Syndrome (ITBS)
What population is Iliotibial Band Syndrome (ITBS) most common in?
Overuse injury more common in runners/cyclists
What LE condition has a physical exam finding significant for localized tenderness that is reproducible with ROM/compression?
Iliotibial Band Syndrome (ITBS)
What are the three subtypes of Knee Bursitis?
- Prepatellar
- Pes anserinus
- Suprapatellar
For which LE condition should you consider aspirating to rule out infection? What treatment should not be done if there is infection?
Knee Bursitis
- Do NOT perform injections if infected
What LE condition involves idiopathic osteonecrosis of subchondral bone? What is the most common location for this to occur?
Osteochondritis Dissecans (OCD) - Most common in the knee joint
If Osteochondritis Dissecans (OCD) is in the elbow, what is the most likely location?
Capitellum (laterally)
If Osteochondritis Dissecans (OCD) is in the knee, what is the most likely location?
Lateral portion of medial femoral condyle from repetitive actions
What age range is most commonly affected by Osteochondritis Dissecans (OCD)?
10-20 years old
What LE condition involves ague symptoms like progressive, deep, poorly localized pain; decreased ROM in elbow but not knee; can include popping, clicking, catching with advanced disease, may have intermittent swelling?
Osteochondritis Dissecans (OCD)
What type of radiology is recommended for Osteochondritis Dissecans (OCD)? What would be seen on imaging?
X-ray
- Would show flattening of articular surface (crater)
What five conditions should be considered if a patient presents with ANTERIOR knee pain?
- Injury of quadriceps/patellar tendons
- Patellofemoral pain syndrome
- Knee bursitis
- Patellar fracture/dislocation
- Osgood-Schlatter disease
What three conditions should be considered if a patient presents with MEDIAL knee pain?
- MCL injury
- Medial meniscus injury
- Pes anserine bursitis
What three conditions should be considered if a patient presents with LATERAL knee pain?
- LCL injury
- IT band syndrome
- Lateral meniscus
What two conditions should be considered if a patient presents with POSTERIOR knee pain?
- Baker’s Cyst
- DVT
Which ankle location is most commonly injured? What specific ligament complex is injured most?
Lateral most commonly injured
- Lateral Ligament Complex (anterior talofibular ligament, calcaneofibular ligament (CFL) and posterior talofibular ligament)
What are the three types of ankle sprains (think location)? What is the MOI for each?
- Lateral: inversion injury
- Medial: eversion injury
- Syndesmotic: rotational injury
What is the physical exam test performed for a lateral ankle sprain?
Anterior Drawer Test
What is the physical exam test performed for a syndesmotic ankle sprain?
Squeeze Test
What is the most important treatment for ankle sprain?
PT
What LE condition is due to increased activity and involves burning pain worse with activity?
Achilles Tendinopathy
What LE condition often involves a sensation of violent “hit or pop” due to sudden pivot or rapid acceleration?
Achilles Tendon Rupture
What Achilles Tendon injury is common in pediatrics?
Calcaneal Apophysitis (Sever’s Disease)
What is the physical exam test performed for an Achilles Tendon Rupture? Describe this.
Thompson Test (+ if squeeze calf of affected Achilles Tendon with no movement of foot)
If an Achilles Tendon Rupture is suspected, what position should the foot be kept in (think for splinting)?
Keeping foot in continued plantar flexed position
What LE condition involves pain with onset of walking (first step in the morning)?
Plantar Fasciitis
What is one of the most common causes of foot pain?
Plantar Fasciitis
With Plantar Fasciitis, what should be ruled out? How do you rule it out (think exams)?
Rule out S1 radiculopathy (weakness with great toe dorsiflexion) with SLR and Achilles DTR
What is an inflammatory arthritis involving hyperuricemia?
Gout
What level is considered hyperuricemia (think exceeds what value)?
Serum uric acid level exceeds 6.8 mg/dL
With Gout, what does uric acid accumulate into?
Uric acid accumulates into monosodium urate (MSU) crystals
What is uric acid? What types of food is it found in?
Uric acid: breakdown product of purine metabolism
- Found in red meat, seafood
What are the two population groups for Gout (think reasons for getting gout)? Which is more common? Describe each
- Underexcretors (90%): more common; due to kidney disease or fluid abnormalities
- Overproducers: due to high cell turnover
What are four non-modifiable risk factors associated with Gout?
- Male
- Older
- Pacific Islanders
- Genetic variants
What are eight modifiable risk factors associated with Gout?
- Obesity
- HTN
- Hyperlipidemia
- CKD
- Type II DM
- Diet
- EtOH
- Certain medications
What is white chalky material consisting of dense concentrations of MSU crystals? What condition are they associated with?
Tophi
- Seen with chronic Gout
What conditions involves rapid onset of severe pain at night?
Acute Gout Flare
What condition is often recurrent, monoarticular, affecting the 1st MTP joint? What is this location site specifically called?
Acute Gout Flare
- 1st MTP joint = “Podagra”
What condition is triggered by acute increase OR decrease in uric acid levels? What two types of medications might cause this?
Acute Gout Flare
- Thiazide loop diuretics
- Urate-lowering medications
What condition shows bony erosions like “punched out” or “rat bite erosions”? What stage of the disease does this occur?
Advanced disease of Gout
What diagnostic test will provide a definitive diagnosis for Gout OR Pseudogout?
Arthrocentesis/synovial fluid analysis
What condition would show + for MSU crystals that are needle-shaped and negatively birefringent on polarized light microscopy?
Gout
What are the three recommended treatments for Acute Gout Flare OR Pseudogout?
- NSAIDs (Indomethacin or Naproxen)
- Steroids
- Colchicine
What is ULT (Urate-Lowering Therapy)? How does it work, and what condition is it used to treat?
ULT treat Gout
- Lowers serum uric acid levels to avoid future attacks by preventing new crystal formation and dissolving those already formed
What prophylactic treatment should be considered when starting ULTs?
Adding NSAIDs or Colchicine
What are Xanthine Oxidase Inhibitors (XOIs) an example of, and what condition do they treat?
XOIs are a type of ULT
- Used to treat Gout
What population group of Gout do XOIs work for?
Underexcretors AND overproducers
What is the DOC for XOIs to treat Gout? What type of dosing should be considered? What are possible side effects of this DOC?
Allopurinol
- Consider renal dosing (low and slow)
- Side effect: SJS
What population group of Gout do Uricosuric Agents work for?
Underexcretors only
When should ULTs NOT be considered for the treatment of Gout? When is the appropriate time to use ULTs?
Acute Gout Flare
- Wait 2 weeks
Why is long-term management of ULTs important?
Non-optimal sUA levels can increase risk for premature mortality
What two metabolic/endocrine disorders are often associated with Pseudogout?
- Hemochromatosis
- Hyperparathyroidism
What are three possible causes/triggers of Acute Pseudogout?
- Trauma
- Surgery
- Severe medical illness
What condition involves severe acute joint inflammation with possible associated systemic findings?
Pseudogout
If an x-ray is performed for Pseudogout, what would be seen on imaging?
Chondrocalcinosis, or “cartilage calcification”
What condition would show + for CPP crystals that are rhomboid-shaped and positively birefringent on polarized light microscopy?
Pseudogout
What are the two subtypes of Axial Spondyloarthritis?
- Ankylosing Spondylitis
- Non-radiographic axial SpA
What are the four subtypes of Peripheral Spondyloarthritis?
- Reactive arthritis
- Psoriatic arthritis
- Arthritis associated with IBD
- Peripheral SpA without any associated illness aka “undifferentiated SpA”
What group of diseases involve a strong association with HLA-B27?
Spondyloarthropathies (SpA)
What group of diseases are generally seronegative (rheumatoid factor (RF) is negative)?
Spondyloarthropathies (SpA)
What subtype of SpA involves inflammation/swelling of LEs, asymmetrical; affects 1-3 joints (oligoarthritis)?
Peripheral SpA
What condition involves inflammation/swelling of entheses, particularly at Achilles tendon?
Enthesitis (“heel pain”)
What subtype of SpA involves acute, non-septic inflammatory arthritis that is asymmetrical oligoarthritis?
Reactive Arthritis (ReA)
Which subtype of SpA is triggered by preceding GI or GU/STD infection 1-4 weeks prior?
Reactive Arthritis (ReA)
What subtype of SpA involves “can’t see, can’t pee, can’t climb a tree”? What does each mean symptomatically?
Reactive Arthritis (ReA)
- “Can’t see”: conjunctivitis, uveitis
- “Can’t pee”: urethritis
- “Can’t climb a tree”: peripheral and/or axial symptoms of peripheral arthritis
What subtype of SpA involves conjunctivitis/uveitis, urethritis and peripheral arthritis?
Reactive Arthritis (ReA) - “Can’t see, can’t pee, can’t climb a tree”
What is the initial treatment for Reactive Arthritis (ReA)? If this doesn’t work, what type of medication should be considered?
NSAIDs with rheumatology referral
- DMARDs can be started
What subtype of SpA involves chronic inflammatory disease of axial skeleton, particularly SI joints and spine?
Ankylosing Spondylitis (AS)
What subtype of SpA involves a STRONG hereditary component?
Ankylosing Spondylitis (AS)
What subtype of SpA involves inflammatory back pain and progressive stiffness of spine?
Ankylosing Spondylitis (AS)
What subtype of SpA progresses proximally?
Ankylosing Spondylitis (AS) - SI joints to outer fibers of annulus fibrosus
What subtype of SpA shows “bamboo spine” appearance with late disease on imaging?
Ankylosing Spondylitis (AS)
What subtype of SpA involves enthesitis with chronic inflammation → structural damage that is attempted to be repaired by new bone formation (ossification) → leads to fusion
Ankylosing Spondylitis (AS)
What subtype of SpA involves limited spine mobility and chest expansion on physical exam?
Ankylosing Spondylitis (AS)
What is the initial treatment for Ankylosing Spondylitis (AS)?
First line is NSAIDs (Indomethacin or Naproxen)
When considering referral to rheumatology, what are the two required requirements for SpA, as well as the list of seven other conditions that 1+ must be present?
Lol sorry this question sucks ass
Patients with >3 months back pain + age onset <45 years + 1 or more of these…
- Positive family history of SpA
- Inflammatory back pain
- HLA-B27 positivity
- Sacroiliitis on imaging
- Extraarticular manifestations
- Good response with NSAIDs
- Elevated acute phase reactants
What condition is a chronic multi-organ autoimmune disorder?
Systemic Lupus Erythematosus (SLE)
What general symptom is often associated with Systemic Lupus Erythematosus (SLE)?
Fatigue
What four skin symptoms are often associated with Systemic Lupus Erythematosus (SLE)?
- Malar rash (“butterfly rash”)
- Discoid
- Painless oral/nasal ulcers
- Raynaud Phenomenon
What cardiac symptom is often associated with Systemic Lupus Erythematosus (SLE)?
At increased risk for MI due to accelerated atherosclerosis
What two renal symptoms are often associated with Systemic Lupus Erythematosus (SLE)?
Nephritis with proteinuria
What condition involves joint pain/joint effusions that tend to be migratory, polyarticular and symmetrical?
Systemic Lupus Erythematosus (SLE)
What condition involves positive ANA (with titer and staining – homogenous and speckled) + subtypes (positive anti-dsDNA, anti-Sm and antiphospholipid antibodies)?
Systemic Lupus Erythematosus (SLE)
What is the first line pharmacologic treatement for Systemic Lupus Erythematosus (SLE)? What referral MUST be made before starting this medication, and why?
Antimalarials (Plaquenil)
- Regular ophthalmology follow-up for Plaquenil and possible retinal toxicity
What three co-morbid disease worsen prognosis for Systemic Lupus Erythematosus (SLE)?
- Active renal disease/infection
- Active CNS disease/infection
- CV disease
What three medications can caused Drug-Induced Lupus?
- Isoniazid
- Procainamide
- Hydralazine
What condition has similar symptoms to Systemic Lupus Erythematosus (SLE)?
Drug-Induced Lupus
What condition involves positive antihistone antibody test; negative anti-dsDNA and anti-Sm antibody?
Drug-Induced Lupus
What condition involves progressive, symmetric proximal muscle weakness most often in deltoids and hip flexors?
Polymyositis
What other systems may be affected by Polymyositis, and which is most important to consider/why?
Lungs: cough/SOB due to interstitial lung disease
- Also Raynaud Phenomenon, esophageal disease, cardiac disease, myocarditis and skin
What is Dermatomyositis?
Polymyositis + cutaneous eruptions
What condition involves increased risk of occult malignancy?
Dermatomyositis
What is an erythematous/violaceous rash on upper eyelids? What condition is it associated with?
Heliotrope rash
- Associated with Dermatomyositis
What is an erythematous/violaceous papules on dorsal aspect of MCP, PIP and DIP joints? What condition is it associated with?
Gottron’s papules
- Associated with Dermatomyositis
What is redness at top of shoulders called? What condition is it associated with?
Shawl sign
- Associated with Dermatomyositis
What two conditions show elevated CK and aldolase on labs?
- Polymyositis
- Dermatomyositis
What is the first line treatment for both Polymyositis and Dermatomyositis?
Steroids
What condition involves systemic, chronic autoimmune inflammatory disorder of exocrine glands/extraglandular features?
Sjögren’s Syndrome
What condition involves “sicca complex”? What are the two symptoms of this complex?
Sjögren’s Syndrome
- Xerophthalmia (dry eyes)
- Xerostomia (dry mouth)
What condition will have a positive Schirmer Test?
Sjögren’s Syndrome
What condition involves +ANA with positive Anti-Ro/SSA and Anti-La/SSB?
Sjögren’s Syndrome
What three specialty referrals are recommended for follow up with Sjögren’s Syndrome?
- Dentist
- Ophthalmologist
- Rheumatologist
What condition involves inflammation of muscular arteries resulting in thrombosis, ischemia, infarct?
Polyarteritis Nodosa (PAN)
What population is more commonly affected by Polyarteritis Nodosa (PAN)?
Most common in males
What condition involves leukocytoclastic vasculitis mostly in LE?
Polyarteritis Nodosa (PAN)
What other two diseases are often associated with Polyarteritis Nodosa (PAN)?
- Renal disease
- HTN
What condition has a negative ANCA (antineutrophil cytoplasmic antibodies)?
Polyarteritis Nodosa (PAN)
What is the first line treatment for Polyarteritis Nodosa (PAN)?
Steroids +/- immunosuppressants
What rare condition involves autoimmune disorder causing diffuse fibrosis (thickening/tightening) of skin/internal organs?
Systemic Sclerosis (SSc)
What are the two subtypes of Systemic Sclerosis (SSc)?
- Limited Cutaneous SSc
- Diffuse Cutaneous SSc
What condition involves CREST? What does each letter stand for (aka what are the symptoms)?
Limited Cutaneous SSc
- Calcinosis
- Raynaud syndrome
- Esophageal dysfunction
- Sclerodactyly
- Telangiectasias
What condition has a +ANA; positive ACA (anti-centromere antibodies)?
Limited Cutaneous SSc
Does Limited Cutaneous SSc or Diffuse Cutaneous SSc have a better prognosis?
Limited Cutaneous SSc has a better prognosis
What condition involves CREST + trunk and proximal extremities involved?
Diffuse Cutaneous SSc
What condition has a +ANA; positive Anti-Scl-70 (Antitopoisomerase I antibodies); or positive Anti-RNA Polymerase III antibody?
Diffuse Cutaneous SSc
What is the recommended treatment for Raynaud Phenomenon?
Nifedipine
What is the most common inflammatory arthritis?
Rheumatoid Arthritis (RA)
What condition involves primarily synovial joints with possible extraarticular manifestations?
Rheumatoid Arthritis (RA)
What condition involves synovial hypertrophy and chronic joint inflammation?
Rheumatoid Arthritis (RA)