MSK Quiz 2: Part 2 Flashcards
What does diarthroses mean?
freely movable
Where is the synovial fluid secreted from?
synoviocytes
what’s the job of the synovial fluid?
nourishes the articular cartilage, shock absorber
What’s the most common of all joint diseases?
osteoarthritis
What is osteoarthritis?
progressive, irreversible loss of joint cartilage
Most commonly affected joints by osteoarthritis?
cervical and lumbosacral spine, hip, knee, 1st MTP joint, hands (DIP, PIP, 1st CMC joint)
Risk factors for osteoarthritis
joint vulnerability (systemic factors, intrinsic joint factors) and joint loading
Systemic risk factors for OA
increased age, female gender, racial/ethnic factors, genetics, nutrition
Intrinsic joint risk factors for OA
previous damage, muscle weakness, increasing bone density, malalignment, proprioceptive deficiencies
Does OA impact extra-articular organs?
No
Does OA impact men or women more?
women
Presentation of OA
pain (bone pain, aching to severe, localized to radiating, affects sleeping), stiffness lasting <30 minutes (worse with inactivity), swelling, joint instability, decreased ROM, locking and grinding
PE OA
TTP, joint effusion, possible deformity, crepitus, antalgic gait, decreased ROM, muscle atrophy
What are OA deformities you can see in the knees?
genu varum, genu valgum
what are OA deformities you can see in teh hands?
Heberden nodes (DIP) and Bouchard nodes (PIP)
Films for OA
Plain films (joint space narrowing, osteophytes, subchondral bone sclerosis/cysts), MRI (r/o if needed), US (not routinely used)
What labs are used for OA?
nothing specific, just r/o other causes
Treatment for OA?
RICE, unloader brace, injections, NSAIDS/tramadol/glcuosamine and chondroitin sulfate, physical therapy/aquatic therapy, patient education, CAM
Surgical options for OA?
arthroscopy is NOT indicated for OA, joint replacement
What’s the most common form of autoimmune arthritis?
Rheumatoid arthritis
What types of joints does RA typically impact?
synovial joints
What’s the cause of RA?
unknown triggers for immune response in synovial tissue
Which genetic marker determines both risk and severity of RA?
HLA-DR4
What are possible triggers of RA?
bacterial antigens (mycobacteria, strep, mycoplasma, e. coli, h. pylori), viral agents (EBV, rubella, parvovirus), smoking, hormonal changes
Risk factors for RA?
female sex, positive family history, older age, smoking, coffee consumption (>3 cups daily)
Who is impacted by RA more, men or women?
women
When does RA occur?
Any age; men <45 is uncommon, women it increases with age until 60 yo
Presentation of RA
insidious to sudden onset pain (affecting distal joints first), stiffness, swelling, possible systemic symptoms (Fatigue, low-grade fever, weight loss); symmetric polyarthritis, morning stiffness (gel phenomenon, lasting more than 1 hour, decreases with physical activity), swelling and tenderness, nodules
PE findings of OA
painful/loss of ROM, possible muscle pain, swelling, deformity, rheumatoid nodules
Affected joints for RA
MCP, PIP (flexor tendon tenosynovitis), MTP, wrist, knees, elbows, ankles, hips, shoulder, C1-C2 articulation, TMJ
When is the DIP joint involved in RA?
almost never
Hand/feet symptoms of RA?
MCP ulnar deviation, swan-neck deformity, boutonniere deformity, nodules, hammer toes
Exta-articular manifestations of RA
rheumatoid nodulosis, pulmonary nodules and fibrosis, vasculitis, pericarditis, musculoskeletal nodules, tenosynovitis, k. sicca, scleritis
Skin symptoms you may see in RA
subcutaenous nodules
Pulmonary symptoms you may see in RA
pleurisy, effusion
cardiovascular symptoms you may see in RA
digital infarcts, ischemic mononeuropathy
Musculoskeletal symptoms you may see in RA
carpal tunnel syndrome, tarsal tunne syndrome, trigger finger
Ocular symptoms you may see in RA
dry eyes, corneal ulcer, scleral injection
Felty’s syndrome is a combination of?
RA, splenomegaly, and neutropenia
Associated complication of Felty’s syndrome
hepatomegaly, thrombocytopenia, lymphandenopathy, fever
Diagnostic tests for RA
RF, ANA, CBC with diff (anemia, thrombocytosis, neutropenia), CRP, ESR, Anti-CCP
Imaging for RA
x-rays (joint erosions)
4 categories for RA criteria
joint involvement, serology, duration of synovitis, acute phase reactants
How many points do you need for criteria for RA?
6/10
Joint Involvement criteria (RA)
1 med/large joint (0), 2-10 med/large joints (1), 1-3 small joints (2), 4-10 small joints (3), >10 joints with at least one small (5)
Serology criteria (RA)
neither RF nor ACPA positive (0), at least one test low positive titre (2), at least one test high positive titre (3)
Duration of synovitis criteria (RA)
<6 weeks (0); >6 weeks (1)
Acute phase reactants criteria RA
neither CRP nor ESR abnormal (O), abnormal CRP or abnormal ESR (1)
Treatment of RA?
lifelong disease without cure; patient education, referral to rheumatologst, braces, splints, orthoses, medications
What’s the goal of RA treatment?
remission
Drug treatment options for RA?
NSAIDS or low-dose prednisolone, intra-articular steroid injection, disease modifying antirheumatic drugs (DMARDs), anti-TNF drugs
What do antirheumatic drugs (DMARDs) do?
target cytokines or receptors in inflammatory cascade, decrease monocolonal antibodies
Examples of antirheumatic drugs?
sulfasalazine, hydroxychloroquine, methotrexate, leflunomide, cyclophosphamide
Anti-TNF drug examples?
infliximab, etanercept, adalimumab, golimumab
RA surgical options?
joint replacement
Describe three components of RA?
inflamed joint capsule and synovial membrane; loss of space in synovial cavity; cartilage destruction
Describe three components of OA?
loose cartilage particles; bone spur; severe cartilage destruction
Fracture presentation
history of an injury with pain and edema, worse over first 1-3 days, TTP
4 phses of fracture healing
1) cellular callus–mesenchymoid cell proliferation, 2) mineralized callus–collagen to cartilage 3) bony callus-lamellar bone replaces mineralized callus 4) remodeling
Fracture complication
ARDS (fat embolism syndrome), atelectasis (early post-op fevers and hypoxemia), DVT, PE, compartment syndrome, nerve or blood vessel injury, failure of normal healing
Five Ps of compartment syndrome
pain out of proportion, paresthesia, pallor, paralysis, pulselessness
Malunion:
incomplete or faulty healing
Delayed union:
slower than normal healing
Non-union:
lack of bony reconstruction
How do you describe position on bone?
proximal, mid, distal
Closed fracture:
no break in the skin
Open fracture:
part of bone protrudes through skin
Complete fracture:
all cortical surfaces are disrupted
What are two types of incomplete fractures?
greenstick, buckle
What’s a greenstick fracture?
one side of bone breaks, the other side is still intact
What’s a buckle fracture?
crunches on one side of the bone
Simple fracture:
single fracture line in 2 bone fragments
Comminuted fracture:
2 or more fracture fragments
Butterfly fracture:
esults from two oblique fracture lines meeting to create a large triangular or wedge-shaped fragment located between the proximal and distal fracture fragments, and resembles a butterfly.
Give examples of fracture line direction
transverse, spiral, oblique
Term for a fracture that disrupts the joint?
intra-articular
Distraction:
a fracture resulting in increased overall bone length (bone fragments are pulled apart)
Impaction:
If there is shortening of bone without loss of alignment, the fracture is impacted. “over riding”
How to describe displacement?
anterior, posterior, lateral, medial (need 2-3 views!)
Angulation:
direction apex is pointing; location of distal fragment
Change in anatomic position in a circular motion is called?
rotation
Partial disruption/displacement of joint:
subluxation
Clavicle fracture MOI
direct blow, fall on outstretched arm
Presentation of clavicle fracture
pain, deformity, grinding at fracture site, sagging shoulder
Treatment of clavicle fracture
based on displacement; conservative (immobilize in sling figure-8 brace for 4-6 weeks) vs. surgery (open reduction internal fixation or intramedullary nail)
Proximal humerus MOI
high energy injury (Fall, MVA)
What classification system do you use for proximal humerus fracture?
Neer Classification
Treatment for proximal humerus fractures?
sling up to 6 weeks, passive ROM after 3 weeks vs. surgery (ORIF vs hemiarthroplasty)
With proximal humerus fractures, which nerve do we worry about?
Axillary
Humeral shaft fracture MOI
trauma, fall