Lupus and Rheumatic Disorders Flashcards
What is systemic lupus erythematosus (SLE)?
chronic multisystemic inflammatory autoimmune disease
Cause of SLE?
unknown
Process of SLE
abnormal immune response -> pathogenic autoantibodies -> deposit in tissue
What autoantibodies are produced in SLE?
antinuclear; antiphospholipid; anti-double-stranded DNA
x% of SLE patients have a family history
10%
Genes affected in SLE have impact on?
innate and/or adaptive immune responses; either increased activation or impaired regulation
Environmental factors of SLE
UV light; drugs (procainamide, hydralazine, quinidine, isoniazid)
Immunologic triggers of SLE
epstein barr, CMV, dietary factors (amino acid L-canavanine)
Hormonal triggers of SLE
strong link to females
Does SLE impact men or women more?
women
Key age of SLE
15-44
constitutional symptoms of SLE
fatigue, malaise, weight loss, fever, lymphadenopathy
skin/hair symptoms of SLE
malar rash, discoid rash, photosensitive rash, Raynaud’s phenomenon, alopecia
MSK symptoms of SLE
polyarthritis, polyarthralgias, myositis
kidney symptoms of SLE
HTN, proteinuria, hematuria, renal failure
CNS symptoms of SLE
seizures, psychosis, stroke, depression, HA
Cardiopulmonary symptoms of SLE
pericarditis, myocarditis, conduction abnormalities, pleuritis, parenchymal lung disease, pulmonary thrombosis, accelerated atherosclerosis with vascular endothelial dysfunction
GI symptoms of SLE
hepatosplenomegaly, pancreatitis, bowel vasculitis
Hematologic system symptoms of SLE
hemolytic anemia, thrombocytopenia
ocular symptoms of SLE
retinal vasculitis, scleritis
Is SLE erosive or non-erosive?
non-erosive
number of joints SLE impacts?
2 or more peripheral joints
Is SLE symmetrical or asymmetrical joint pain?
Symmetrical
Common SLE impacted joints
wrist, MCP, PIP