MSK-General diseases

Question 1

Describe Paget’s disease

Answer 1

Disease of increased but uncontrolled bone turnover, a disorder of osteoclasts. Predisposing factors are increasing age, male, family history .
Presents with bone pain, raised ALP

Question 2

Describe koebner phenomenon

Answer 2

Skin lesions occuring due to trauma in someone with pre-exisiting psoriasis

Question 3

How to differentiate between gout and pseudogout

Answer 3

Pseudogout- calcium phosphate crystals with postitive befringement and rhomboid shapes under microscopy.
Gout- Urate crystals- negative birefringent – they will appear a needle shaped crystals