MSK & CTD - Specific Findings

Question 1

Keratin perals

Answer 1

Seen in various types of squamous cell carcinoma

Question 2

Nests of basaloid cells within the dermis

Answer 2

Basal cell carcinoma of skin

Question 3

Common genetic mutation in melanoma

Answer 3

Braf kinase activating mutation

Question 4

Tumor marker for melanoma

Answer 4

S-100 protein

Question 5

Nikolsky sign

Answer 5

Separation of the epidermis with mechanical stroking

Seen in pemphigoid vulgaris but NOT in bullous pemphigoid

Question 6

Heberden’s nodes

Answer 6

Osteophytes (bony spurs) at the DIPs

Seen in osteoarthritis

Question 7

Bouchard’s nodes

Answer 7

Osteophytes (bony spurs) of the PIPs

Seen in osteoarthritis

Question 8

Brown tumor of bone

Answer 8

Cystic bone space filled with brown fibrous tissue

Seen in osteitis fibrous cystica (primary hyperparathyroidism)