MSK Flashcards

1
Q

Which type of collagen is affected with osteogenesis imperfecta?

A

Abnormality in the production, processing, or export of type I collagen from osteoblasts and fibroblasts.

-Type I collagen is composed of 2 α1 chains and 1 α2 chain. The COL1A1 and COL1A2 genes encode the α1 and α2 chains

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