MSK Flashcards
1
Q
Which type of collagen is affected with osteogenesis imperfecta?
A
Abnormality in the production, processing, or export of type I collagen from osteoblasts and fibroblasts.
-Type I collagen is composed of 2 α1 chains and 1 α2 chain. The COL1A1 and COL1A2 genes encode the α1 and α2 chains