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Random Finals Points > MSK > Flashcards

MSK Flashcards

1
Q

What is used to diagnose Duchenne’s, what is the clinical picture?

A

Genetic Analysis, raised CK

  • calf hypertrophy
  • Gowers sign +ve
  • dilated cardiomyopathy
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2
Q

Management of Temporal Arteritis for someone with evolving vision loss?

A

IV Methylprednisilone

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3
Q

What should be measured in suspected drug induced lupus?

A

Anti-Histone antibodies

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4
Q

Treatment of choice for septic arthritis?

A

Flucloxacillin
Clindamycin for penicillin allergic

  • Joint decompression/lavage
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5
Q

Finding on temporal artery biopsy in TCA?

A

skip lesions

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6
Q

Most common causative organism septic arthritis?

A
  1. Staph aureus UNLESS YOUNG Neisseria gonorrhoeae
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7
Q

When should Uric acid be rechecked gout?

A

2 weeks after gout has settled

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8
Q

What is the most common adverse effect of Hydroxychloroquine?

A

Bull’s eye retinopathy

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9
Q

What spondyloarthropathy is associated with IBD?

A

Enteropathic arthritis

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10
Q

3 important points about Aziathiopurine?

A
  1. Thiopurine methyltransferase activity needs to be tested before hand
  2. Major interaction with allopurinol
  3. Safe in pregnancy
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11
Q

Used instead of Bisphosphonates if eGFR< 35 or not tolerated?

A

Denosumab: inhibits RANKL so prevents development of osteoclasts

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12
Q

What needs to be performed before commencing biologic treatment?

A

CXR

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13
Q

Most likely blood finding in Paget’s disease?

A

Isolated raised ALP

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14
Q

Finding on x-ray for ankylosing spongylitis?

A
  1. Syndesmophytes;: ossification
  2. Sacroillitis
  3. Squaring of lumber vertebrae
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15
Q

What drug are patients with aspirin allergy/sulphonamide drug also likely to be allergic to?

A

Sulfasalazine

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16
Q

Name 4 side effects of sulfasalazine?

A
  1. Steven Johnson Syndrome
  2. Oligospermia
  3. Heinz body anaemia/Megaloblastic anaemia
  4. coloured tears
17
Q

What do you manage acute flares of Rheumatoid Arthritis with?

A

IV or PO corticosteroids (Methylprednisolone/ Prednisolone)

18
Q

How many NSAIDs have to be trialled in ankylosing spondylitis for anti TNF Treatment

A

2

19
Q

What immunoglobin is found in breast milk

A

IgA

20
Q

Proximal myopathy + Waddling gait=?

A

Osteomalacia

21
Q

Most common tumour associated with diaphysis of the long bone?

A

Ewing’s

22
Q

Where is Paget’s most likely to be?

A

Pelvis, Lumbar spine, Skull

23
Q

What dermatological condition is associated with reactive arthritis?

A

Keratoderma Blenorrhagica

24
Q

What is the main side effect of Colchicine?

A

Diarrhoea

25
Q

What drug should be used in renal complications of systemic sclerosis?

A

ACEi

26
Q

What is useful for monitoring an SLE flare?

A

Completent (LOW) anti dsDNA (high)

27
Q

What condition (not rheum) is reactive arthritis strongly associated with?

A

IHD

28
Q

Heart problem associated with Ehler-Danlos?

What collagen does it affect?

A

Aortic Regurgitation, mitral valve prolapse and aortic dissection

  • Type 2
29
Q

Azathioprine and Allopurinol can both cause what?

A

Severe bone marrow suppression

30
Q

In Rheumatoid Hx of Psychiatric Disease?

A

SLE

31
Q

What cancer are patients with Sjogren’s more at risk of?

A

Lymphoma

32
Q

What atypical fracture is bisphosphonate associated with

?

A

Proximal femoral shaft

33
Q

Associations of good prognosis in Rheumatoid Arthritis

A

Rheumatoid Factor Negative

Random Finals Points (9 decks)

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